Chapter 27: Coagulation Modifier Drugs
Sealock: Lilley’s Pharmacology for Canadian Health Care Practice
MULTIPLE CHOICE
1. A female patient has been prescribed warfarin (Coumadin®) in addition to a heparin infusion. What
is the reason for her receiving two anticoagulants?
a. The oral and injection forms work synergistically.
b. The combination of heparin and an oral anticoagulant results in fewer adverse effects than
heparin used alone.
c. Oral anticoagulants are used to reach an adequate level of anticoagulation when heparin alone
is unable to do so.
d. When oral anticoagulants are prescribed, heparin is often used to initiate therapy until
laboratory tests indicate an adequate therapeutic response.
ANS: D
When oral anticoagulants are prescribed, heparin is often also prescribed to initiate therapy until
laboratory tests indicate an adequate therapeutic response has been achieved.
DIF: Cognitive Level: Comprehension
2. Which is a true statement about dipyridamole (Persantine®)?
a. It has anti-inflammatory and antipyretic properties.
b. It has analgesic properties and antithrombotic effects.
c. It is useful for reducing the risk of fatal and nonfatal thrombotic stroke.
d. It is used as an adjunct to warfarin in the prevention of postoperative thromboembolic
complications.
ANS: D
Dipyridamole is used as an adjunct to warfarin (Coumadin) in the prevention of postoperative
thromboembolic complications.
DIF: Cognitive Level: Knowledge
, 3. What is the most frequent adverse effect of thrombolytic therapy?
a. Dysrhythmia
b. Nausea and vomiting
c. Anaphylactic reactions
d. Internal and superficial bleeding
ANS: D
Bleeding, both internal and superficial as well as intracranial, are the most frequent adverse effects of
thrombolytic therapy.
DIF: Cognitive Level: Comprehension
4. What is the recommended antidote for warfarin (Coumadin) toxicity?
a. Vitamin E
b. Vitamin K
c. Protamine sulphate
d. Potassium phosphate
ANS: B
High doses of vitamin K given intravenously should reverse the anticoagulation effects of warfarin
toxicity.
DIF: Cognitive Level: Application
5. The nurse is administering heparin subcutaneously.
Which instruction for doing this is correct?
a. Aspirate before injecting.
Sealock: Lilley’s Pharmacology for Canadian Health Care Practice
MULTIPLE CHOICE
1. A female patient has been prescribed warfarin (Coumadin®) in addition to a heparin infusion. What
is the reason for her receiving two anticoagulants?
a. The oral and injection forms work synergistically.
b. The combination of heparin and an oral anticoagulant results in fewer adverse effects than
heparin used alone.
c. Oral anticoagulants are used to reach an adequate level of anticoagulation when heparin alone
is unable to do so.
d. When oral anticoagulants are prescribed, heparin is often used to initiate therapy until
laboratory tests indicate an adequate therapeutic response.
ANS: D
When oral anticoagulants are prescribed, heparin is often also prescribed to initiate therapy until
laboratory tests indicate an adequate therapeutic response has been achieved.
DIF: Cognitive Level: Comprehension
2. Which is a true statement about dipyridamole (Persantine®)?
a. It has anti-inflammatory and antipyretic properties.
b. It has analgesic properties and antithrombotic effects.
c. It is useful for reducing the risk of fatal and nonfatal thrombotic stroke.
d. It is used as an adjunct to warfarin in the prevention of postoperative thromboembolic
complications.
ANS: D
Dipyridamole is used as an adjunct to warfarin (Coumadin) in the prevention of postoperative
thromboembolic complications.
DIF: Cognitive Level: Knowledge
, 3. What is the most frequent adverse effect of thrombolytic therapy?
a. Dysrhythmia
b. Nausea and vomiting
c. Anaphylactic reactions
d. Internal and superficial bleeding
ANS: D
Bleeding, both internal and superficial as well as intracranial, are the most frequent adverse effects of
thrombolytic therapy.
DIF: Cognitive Level: Comprehension
4. What is the recommended antidote for warfarin (Coumadin) toxicity?
a. Vitamin E
b. Vitamin K
c. Protamine sulphate
d. Potassium phosphate
ANS: B
High doses of vitamin K given intravenously should reverse the anticoagulation effects of warfarin
toxicity.
DIF: Cognitive Level: Application
5. The nurse is administering heparin subcutaneously.
Which instruction for doing this is correct?
a. Aspirate before injecting.
