osteoarthritis - AnswersMost common form of arthritis
•
Increased age
-
> 45, particularly by 70's
•
Female gender, post
-
menopausal
•
Obesity increases risk
threefold
•
Family history
•
Repeated trauma - AnswersOA risk factors include:
systemic inflammation & knee - AnswersOA is generally NOT associated with
---------- and the ------- is the most common area to be affected
-
Pain most prominent symptom
-
Insidious onset
-
Generally limited to joint(s)
,-
"Aching
" pain worsened with joint use
-
Stiffness with inactivity, morning
-
One or few joints involved (diff dx) - AnswersS&S of OA include:
< 2000 cells /
mcL
(if
done) - AnswersJoint fluid WBC for OA is:
Topical NSAIDs
-
Acetaminophen first line oral
-
Oral NSAIDS: OTC or prescribed
•
COX1 and COX2 vs. selective COX2
•
Consider gastric acid reduction / protection therapy
•
Monitor renal baseline and toxicity
•
Permeant platelet inhibition
-
, bleeding risk - AnswersPharmacotherapy for OA includes
Rheumatoid arthritis - AnswersChronic, systemic inflammatory disease
•
Primarily targets synovial tissues
•
Higher risk of coronary artery disease and
heart failure
•
Untreated results in joint destruction and
reduced life
expectancy
•
Early and aggressive treatment
Women > men
•
Risk increases with age
-
Uncommon for men to present age < 45
-
Prevalence in women
plateaus
~ age 60 - AnswersRisk factors for RA
Anti
-
CCP antibodies highest specificity