N329 Quiz 1 UPDATED ACTUAL Exam
Questions and CORRECT Answers
Bleeding
Pain
Infection
Perforation - CORRECT ANSWER - Complications of PUD (4)
PUD - CORRECT ANSWER - Imbalance between stomach mucosal defensive and
aggressive factors
Erosions
Ulcerations - CORRECT ANSWER - 2 major aspects of PUD (vary in depth and location)
Zollinger-Ellison Syndrome - CORRECT ANSWER - Hypersecretion of gastric juices;
development of peptic ulcers; *caused by secretion of gastrin from a gastrin-producing tumor*
Superficial to deeper in gastric glands - atrophy - CORRECT ANSWER - Layers involved
with ulcers
H pylori
NSAIDs
Acid
Pepsin
Smoking - CORRECT ANSWER - Aggressive factors of gastric ulceritis
Mucus
Bicarb
Blood flow
,Prostaglandins - CORRECT ANSWER - Defensive factors of gastric ulceritis
Mucus - CORRECT ANSWER - Secreted by GI cells of GI mucosa; forms a barrier to
protect underlying cells from acid and pepsin
Bicarb - CORRECT ANSWER - Secreted by epithelial cells of stomach and duodenum;
most remains trapped in the mucus layer to neutralize hydrogen ions that penetrate mucus
Blood flow - CORRECT ANSWER - Cells need adequate of this to stay healthy
Prostaglandins (decrease acid production
*but also can cause uterine contractions* - CORRECT ANSWER - Stimulate the secretion
of mucus and bicarbonate, increase GI blood flow
H pylori - CORRECT ANSWER - Gram (-) bacillus that can colonize stomach and
duodenum (60-70% of pts with PUD have this bacteria present) *additional factors must be
involved*
NSAIDs - CORRECT ANSWER - Inhibit the biosynthesis of prostaglandins; decrease
blood flow, mucus, and bicarbonate
Gastric acid - CORRECT ANSWER - Directly injures the cells of the GI mucosa;
activates pepsin (a proteolytic enzyme) *increased of this alone will not cause ulcers*
Delays healing
Increased risk for recurrence - CORRECT ANSWER - How does smoking affect PUD
PUD - CORRECT ANSWER - S/S:
Lots of pain
nausea
, gassy
common to have reflux
PUD (except for antibiotics) - CORRECT ANSWER - Drug therapy for this creates
conditions conducive to healing but *does not* alter the disease state
Alleviate symptoms
Promote healing
Prevent complications
Prevent reoccurrence - CORRECT ANSWER - What are the goals of PUD therapy? (4)
Eradicate H pylori
Reduce gastric acid
Enhance mucosal defenses - CORRECT ANSWER - How do these drugs overall act on
PUD:
Antibiotics
Antisecretory agents
Mucosal protectants
Antacids
Symptomatic - CORRECT ANSWER - With H. pylori - not everyone affected is ___
Gastric *cancer* - CORRECT ANSWER - H pylori increases the risk for:
Between epithelial cells and the mucous barrier - CORRECT ANSWER - Where does H
pylori specifically colonize?
Antibiotics
Questions and CORRECT Answers
Bleeding
Pain
Infection
Perforation - CORRECT ANSWER - Complications of PUD (4)
PUD - CORRECT ANSWER - Imbalance between stomach mucosal defensive and
aggressive factors
Erosions
Ulcerations - CORRECT ANSWER - 2 major aspects of PUD (vary in depth and location)
Zollinger-Ellison Syndrome - CORRECT ANSWER - Hypersecretion of gastric juices;
development of peptic ulcers; *caused by secretion of gastrin from a gastrin-producing tumor*
Superficial to deeper in gastric glands - atrophy - CORRECT ANSWER - Layers involved
with ulcers
H pylori
NSAIDs
Acid
Pepsin
Smoking - CORRECT ANSWER - Aggressive factors of gastric ulceritis
Mucus
Bicarb
Blood flow
,Prostaglandins - CORRECT ANSWER - Defensive factors of gastric ulceritis
Mucus - CORRECT ANSWER - Secreted by GI cells of GI mucosa; forms a barrier to
protect underlying cells from acid and pepsin
Bicarb - CORRECT ANSWER - Secreted by epithelial cells of stomach and duodenum;
most remains trapped in the mucus layer to neutralize hydrogen ions that penetrate mucus
Blood flow - CORRECT ANSWER - Cells need adequate of this to stay healthy
Prostaglandins (decrease acid production
*but also can cause uterine contractions* - CORRECT ANSWER - Stimulate the secretion
of mucus and bicarbonate, increase GI blood flow
H pylori - CORRECT ANSWER - Gram (-) bacillus that can colonize stomach and
duodenum (60-70% of pts with PUD have this bacteria present) *additional factors must be
involved*
NSAIDs - CORRECT ANSWER - Inhibit the biosynthesis of prostaglandins; decrease
blood flow, mucus, and bicarbonate
Gastric acid - CORRECT ANSWER - Directly injures the cells of the GI mucosa;
activates pepsin (a proteolytic enzyme) *increased of this alone will not cause ulcers*
Delays healing
Increased risk for recurrence - CORRECT ANSWER - How does smoking affect PUD
PUD - CORRECT ANSWER - S/S:
Lots of pain
nausea
, gassy
common to have reflux
PUD (except for antibiotics) - CORRECT ANSWER - Drug therapy for this creates
conditions conducive to healing but *does not* alter the disease state
Alleviate symptoms
Promote healing
Prevent complications
Prevent reoccurrence - CORRECT ANSWER - What are the goals of PUD therapy? (4)
Eradicate H pylori
Reduce gastric acid
Enhance mucosal defenses - CORRECT ANSWER - How do these drugs overall act on
PUD:
Antibiotics
Antisecretory agents
Mucosal protectants
Antacids
Symptomatic - CORRECT ANSWER - With H. pylori - not everyone affected is ___
Gastric *cancer* - CORRECT ANSWER - H pylori increases the risk for:
Between epithelial cells and the mucous barrier - CORRECT ANSWER - Where does H
pylori specifically colonize?
Antibiotics
