NR 507 / NR507 Pathophysiolgy Midterm
Review Week 1-3 Questions with Correct
Answers Latest 2025/2026
Hypersensitivity Type 1 - ANSWER -Mediated by IgE
-Inflammation due to mast cell degranulation
*local symptoms: itching, rash (immediate, wide distributed)
*systemic symptoms: wheezing
**Most Dangerous form: Anaphylaxis-systemic response, hypotension, severe
bronchospasm
*tx: epinephrine
Hypersensitivity Type 2 - ANSWER *Cytotoxic: tissue specific (toxic
to thyroid)
**ex graves-hyperthyroid, does not destroy, alters
**ex. incompatible blood, cells destroyed
*Macrophages primary effectors
-can cause tissue damage or alter function
Hypersensitive Type 3 - ANSWER **Not organ specific
-Bind to soluble antigen outside cell
*Neutrophil primary effector cell
-ex. rheumatoid arthritis: joints
Hypersensitivity Type 4 - ANSWER **Delayed response (rash only at
site of contact)
** T-cell mediated
-ex. poison ivy, contact dermatitis
, -tx. topical corticoid steroid, No antihistamines or abx
Autoimmunity - ANSWER *genetic (*may not be the same
autoimmune disease)
Alloimmunity - ANSWER *immune system reacts against tissue of
other member same species (human to human)
Examples....
* transplant rejection
*transfusion rejection
Two Types of Immunodeficency - ANSWER Primary
Secondary
Primary Immunodeficiency - ANSWER -single gene defects
-something lacking within immune system
example. B-lymphocyte deficiency: most severe
Secondary Immunodeficiency - ANSWER -complication of other
physiological condition
**malnutrition most common cause world wide
example: HIV pt gets pneumocystis
Anemia (8) - ANSWER Iron Deficiency
Vit B12
Folate Deficiency
Hemolytic Anemia
Acute Blood Loss Anemia
Review Week 1-3 Questions with Correct
Answers Latest 2025/2026
Hypersensitivity Type 1 - ANSWER -Mediated by IgE
-Inflammation due to mast cell degranulation
*local symptoms: itching, rash (immediate, wide distributed)
*systemic symptoms: wheezing
**Most Dangerous form: Anaphylaxis-systemic response, hypotension, severe
bronchospasm
*tx: epinephrine
Hypersensitivity Type 2 - ANSWER *Cytotoxic: tissue specific (toxic
to thyroid)
**ex graves-hyperthyroid, does not destroy, alters
**ex. incompatible blood, cells destroyed
*Macrophages primary effectors
-can cause tissue damage or alter function
Hypersensitive Type 3 - ANSWER **Not organ specific
-Bind to soluble antigen outside cell
*Neutrophil primary effector cell
-ex. rheumatoid arthritis: joints
Hypersensitivity Type 4 - ANSWER **Delayed response (rash only at
site of contact)
** T-cell mediated
-ex. poison ivy, contact dermatitis
, -tx. topical corticoid steroid, No antihistamines or abx
Autoimmunity - ANSWER *genetic (*may not be the same
autoimmune disease)
Alloimmunity - ANSWER *immune system reacts against tissue of
other member same species (human to human)
Examples....
* transplant rejection
*transfusion rejection
Two Types of Immunodeficency - ANSWER Primary
Secondary
Primary Immunodeficiency - ANSWER -single gene defects
-something lacking within immune system
example. B-lymphocyte deficiency: most severe
Secondary Immunodeficiency - ANSWER -complication of other
physiological condition
**malnutrition most common cause world wide
example: HIV pt gets pneumocystis
Anemia (8) - ANSWER Iron Deficiency
Vit B12
Folate Deficiency
Hemolytic Anemia
Acute Blood Loss Anemia
