WGU D027 PRACTICE TEST
QUESTIONS AND ANSWERS WITH
VERIFIED SOLUTIONS 100% CORRECT
RATED A+ NEWLY UPDATED 2025
A patient has had multiple dose adjustments of a tricyclic antidepressant. The
provider recommends genetic testing. What is the correct rationale for this
recommendation?
a. The CYP2D6 gene influences metabolism of tricyclic antidepressants and
certain other drugs. ✔✔
b. The HER2 gene is a tumor marker that impacts metabolism of tricyclic
antidepressants.
c. The BRCA2 gene influences metabolism of certain drugs and increases the risk
for breast cancer.
d. The X-linked OPN1MW gene for male color blindness also slows metabolism of
certain drugs.
📝 Explanation: CYP2D6 is responsible for metabolizing approximately 25% of
all prescribed drugs, including TCAs (tricyclic antidepressants), beta blockers, and
neuroleptics. Variants in this gene can cause people to metabolize drugs too slowly
or too quickly, requiring dosage adjustments.
According to the CDC, which four chronic conditions are the most costly (in
order from most to least)?
a. Cardiovascular diseases, obesity, diabetes, cancer
b. Cardiovascular diseases, diabetes, obesity, cancer
✔✔ c. Cardiovascular diseases, smoking-related conditions, alcohol-related
conditions, diabetes
d. Cardiovascular diseases, stroke, obesity, diabetes
📝 Explanation: The CDC identifies cardiovascular diseases, smoking-related
conditions, alcohol-related conditions, and diabetes as the top four most expensive
,chronic health issues due to their widespread prevalence and the long-term cost of
treatment and complications.
A mother brought her child to the doctor for genetic testing. The health care
provider was trying to explain the genetic results of the child. During his
explanation he tells the mother that the child has 2 X chromosomes and a Y
chromosome in each cell. He begins to explain some physical appearances the
mother might notice on her son. He explains that she might notice that he has
sparse body hair, long limbs and small testes. The health care practitioner is
explaining which syndrome to the mother.
a. Klinefelter syndrome
b. Turners' syndrome
c. Down syndrome
d. Kawasaki's disease - ANSWER✔✔a. Klinefelter syndrome
Klinefelter syndrome is an individual with at least 2 X chromosomes and a Y
chromosome in each cell. Because of the Y chromosome these individuals have a
male appearance, but they are usually sterile and about half develop female-like
breasts.
A patient reports a maternal family history of Lynch syndrome. Which laboratory
finding might indicate a need for further testing for the presence of Lynch
syndrome in this patient?
a. Elevated thyroid-stimulating hormone
b. Low cortisol level
c. Positive heme-occult test
, d. Sputum positive for Pseudomonas Aeruginosa - ANSWER✔✔a. Positive heme-
occult test
Positive heme-occult because Lynch syndrome is a hereditary form of colorectal
cancer and colorectal bleeding can be a sign of cancer
An individual's acquired immunity is dependent on the function of which cells?
(Select all that apply.)
a. B lymphocytes
b. Opsonins
c. T lymphocytes
d. Macrophages - ANSWER✔✔a. B lymphocytes
c. T lymphocytes
d. Macrophages
T lymphocytes, B lymphocytes, macrophages, and dendritic cells are involved in
acquired immunity.
A 17-year-old female comes to the clinic for a physical exam. As part of the visit,
the APRN considers her risk factors for type 2 diabetes mellitus (T2DM). Risk
factors for T2DM would likely include all of the following except:
a. Native American ancestry
b. Family history of type 1 diabetes mellitus (T1DM)
c. Obesity
QUESTIONS AND ANSWERS WITH
VERIFIED SOLUTIONS 100% CORRECT
RATED A+ NEWLY UPDATED 2025
A patient has had multiple dose adjustments of a tricyclic antidepressant. The
provider recommends genetic testing. What is the correct rationale for this
recommendation?
a. The CYP2D6 gene influences metabolism of tricyclic antidepressants and
certain other drugs. ✔✔
b. The HER2 gene is a tumor marker that impacts metabolism of tricyclic
antidepressants.
c. The BRCA2 gene influences metabolism of certain drugs and increases the risk
for breast cancer.
d. The X-linked OPN1MW gene for male color blindness also slows metabolism of
certain drugs.
📝 Explanation: CYP2D6 is responsible for metabolizing approximately 25% of
all prescribed drugs, including TCAs (tricyclic antidepressants), beta blockers, and
neuroleptics. Variants in this gene can cause people to metabolize drugs too slowly
or too quickly, requiring dosage adjustments.
According to the CDC, which four chronic conditions are the most costly (in
order from most to least)?
a. Cardiovascular diseases, obesity, diabetes, cancer
b. Cardiovascular diseases, diabetes, obesity, cancer
✔✔ c. Cardiovascular diseases, smoking-related conditions, alcohol-related
conditions, diabetes
d. Cardiovascular diseases, stroke, obesity, diabetes
📝 Explanation: The CDC identifies cardiovascular diseases, smoking-related
conditions, alcohol-related conditions, and diabetes as the top four most expensive
,chronic health issues due to their widespread prevalence and the long-term cost of
treatment and complications.
A mother brought her child to the doctor for genetic testing. The health care
provider was trying to explain the genetic results of the child. During his
explanation he tells the mother that the child has 2 X chromosomes and a Y
chromosome in each cell. He begins to explain some physical appearances the
mother might notice on her son. He explains that she might notice that he has
sparse body hair, long limbs and small testes. The health care practitioner is
explaining which syndrome to the mother.
a. Klinefelter syndrome
b. Turners' syndrome
c. Down syndrome
d. Kawasaki's disease - ANSWER✔✔a. Klinefelter syndrome
Klinefelter syndrome is an individual with at least 2 X chromosomes and a Y
chromosome in each cell. Because of the Y chromosome these individuals have a
male appearance, but they are usually sterile and about half develop female-like
breasts.
A patient reports a maternal family history of Lynch syndrome. Which laboratory
finding might indicate a need for further testing for the presence of Lynch
syndrome in this patient?
a. Elevated thyroid-stimulating hormone
b. Low cortisol level
c. Positive heme-occult test
, d. Sputum positive for Pseudomonas Aeruginosa - ANSWER✔✔a. Positive heme-
occult test
Positive heme-occult because Lynch syndrome is a hereditary form of colorectal
cancer and colorectal bleeding can be a sign of cancer
An individual's acquired immunity is dependent on the function of which cells?
(Select all that apply.)
a. B lymphocytes
b. Opsonins
c. T lymphocytes
d. Macrophages - ANSWER✔✔a. B lymphocytes
c. T lymphocytes
d. Macrophages
T lymphocytes, B lymphocytes, macrophages, and dendritic cells are involved in
acquired immunity.
A 17-year-old female comes to the clinic for a physical exam. As part of the visit,
the APRN considers her risk factors for type 2 diabetes mellitus (T2DM). Risk
factors for T2DM would likely include all of the following except:
a. Native American ancestry
b. Family history of type 1 diabetes mellitus (T1DM)
c. Obesity
