Pharm Test 1
Pharmacodynamics
what the drug does to the body
Pharmacokinetics
what the body does to the drug
Absorption
Transportation of unmetabolized drug from administration site to circulatory system
Distribution
Reversible transfer of a drug from one location to another in body
Metabolism
Process of chemically altering drug in the body to make it easier to eliminate
Elimination
Removal of administered drug from body
Half-Life
Time it takes for amount of drug's active substance in body to reduce by half
, Pharm Test 1
first pass effect
when drug molecules in stomach & intestines are diverted into hepatic portal circulation
before they have a chance to enter systemic circulation
How does grapefruit juice interact with certain drugs?
inhibits cytochrome P-450 3A4 (CYP34A) enzyme in small intestine
Agonist
substance that binds to a cell's receptor & triggers a biological response
Antagonist
substance that blocks or reduces effect of another substance
MOA
biochemical process by which a drug produces its intended effect in body
Generic name
chemical name of a drug that's the same no matter who manufactures it (lower case)
Brand name
Pharmacodynamics
what the drug does to the body
Pharmacokinetics
what the body does to the drug
Absorption
Transportation of unmetabolized drug from administration site to circulatory system
Distribution
Reversible transfer of a drug from one location to another in body
Metabolism
Process of chemically altering drug in the body to make it easier to eliminate
Elimination
Removal of administered drug from body
Half-Life
Time it takes for amount of drug's active substance in body to reduce by half
, Pharm Test 1
first pass effect
when drug molecules in stomach & intestines are diverted into hepatic portal circulation
before they have a chance to enter systemic circulation
How does grapefruit juice interact with certain drugs?
inhibits cytochrome P-450 3A4 (CYP34A) enzyme in small intestine
Agonist
substance that binds to a cell's receptor & triggers a biological response
Antagonist
substance that blocks or reduces effect of another substance
MOA
biochemical process by which a drug produces its intended effect in body
Generic name
chemical name of a drug that's the same no matter who manufactures it (lower case)
Brand name
