Robbinsg&gCotrangReviewgofgPatholog Pg.g17
2. AcutegandgChronicgInflammation y
PBD7gandgPBD8gChapterg2:gAcutegandgChronicgInflammation
BP7gandgBP8gChapterg2:gAcutegandgChronicgInflammation
1 Ingag6-monthgrandomizedgtrialgofgagpharmacologicgagent,goneggroupgofgpatientsgreceivesgagcyclooxygenase-2g(COX-
2)ginhibitor,gandgagcontrolggroupgdoesgnot.gLaboratorygmeasurementsgduringgthegtrialgshowgnogsignificantgdifferencesgbet
weengtheggroupsgingWBCgcount,gplateletgcount,ghemoglobin,gandgcreatinine.gTheggroupgreceivinggthegdruggreportsgs
ubjectivegfindingsgdifferentgfromgthosegofgthegcontrolggroup,ghowever.gWhichgofgthegfollowinggfindingsgwasgmostglikelygre
portedgbygtheggroupgreceivinggthegdrug?
□ (A)gAnklegswelling
□ (B)gIncreasedgboutsgofgasthma
□ (C)gEasygbruisability
□ (D)gReducedgurticaria
□ (E)gIncreasedgfebrilegepisodes
□ (F)gReducedgarthritisgpain
2 Angexperimentgintroducesgbacteriagintogagperfusedgtissuegpreparation.gLeukocytesgleavegthegvasculaturegandgmigrateg
togthegsitegofgbacterialginoculation.gThegmovementgofgthesegleukocytesgisgmostglikelygtogbegmediatedgbygwhichgofgthegfoll
owinggsubstances?
□ (A)gBradykinin
□ (B)gChemokines
□ (C)gHistamine
□ (D)gProstaglandins
□ (E)gComplementgC3a
3 Ag53-year-
oldgwomanghasghadgaghighgfevergandgcoughgproductivegofgyellowishgsputumgforgthegpastg2gdays.gHergvitalgsignsgincludeg
temperaturegofg37.8°C,gpulsegofg83/min,grespirationsgofg17/min,gandgbloodgpressuregofg100/60gmmgHg.gOngausc
ultationgofgthegchest,gcracklesgaregaudiblegingbothglunggbases.gAgchestgradiographgshowsgbilateralgpatchygpulmonarygi
nfiltratesgandgfluidgingthegrightgpleuralgcavity.gThoracentesisgyieldsg500gmLgofgcloudygyellowgfluid.gWhichgofgthegfollowi
ngginflammatorygcellgtypesgisgmostglikelygtogbegseenginggreatlygincreasedgnumbersgingagsputumgspecimen?
□ (A)gMacrophages
□ (B)gNeutrophils
□ (C)gMastgcells
□ (D)gSmallglymphocytes
□ (E)gLanghansggiantgcells
4 Ag63-year-
oldgmangdevelopsgworseninggcongestivegheartgfailureg2gweeksgaftergangacutegmyocardialginfarction.gAngechocardi
ogramgshowsgagmarkedlygdecreasedgejectiongfraction.gHegdiesg1gdayglater.gAtgautopsy,gagsectiongofgtheginfarctgshow
sgthatgthegnecroticgmyocardiumghasglargelygbeengreplacedgbygcapillaries,gfibroblasts,gandgcollagen.gVariousginfl
ammatorygcellsgaregpresent.gWhichgofgthegfollowingginflammatorygcellgtypesgingthisglesiongplaysgthegmostgimportantgrolegin
gtheghealinggprocess?
□ (A)gMacrophages
, Robbinsg&gCotrangReviewgofgPatholog Pg.g18
□ (B)gPlasmagcells y
, Robbinsg&gCotrangReviewgofgPatholog Pg.g19
y
□ (C)gNeutrophils
□ (D)gEosinophils
□ (E)gEpithelioidgcells
5 Ag10-year-
oldgchildgdevelopedgagsoregthroatgandgfevergoverg24ghours.gPhysicalgexaminationgshowsgpharyngealgerythemagandgswe
lling.gLaboratorygfindingsgincludegleukocytosis.gThegchildgisggivengacetylsalicylicgacidg(aspirin).gWhichgofgthegfollow
inggfeaturesgofgtheginflammatorygresponsegisgmostgaffectedgbygthisgdrug?
□ (A)gVasodilation
□ (B)gChemotaxis
□ (C)gPhagocytosis
□ (D)gEmigrationgofgleukocytes
□ (E)gReleasegofgleukocytesgfromgbonegmarrow
6 Agwomangwhogisgallergicgtogcatsgvisitsgagneighborgwhoghasgseveralgcats.gDuringgthegvisit,gsheginhalesgcatgdander,g
andgwithingminutes,gshegdevelopsgnasalgcongestiongwithgabundantgnasalgsecretions.gWhichgofgthegfollowinggsubstancesgi
sgmostglikelygtogproducegthesegfindings?
□ (A)gBradykinin
□ (B)gComplementgC5a
□ (C)gHistamine
□ (D)g Interleukin-1
□ (E)gPhospholipasegC
□ (F)gPlatelet-activatinggfactor
□ (G)gTumorgnecrosisgfactor
7 Ag32-year-
oldgwomanghasghadgagchronicgcoughgwithgfevergforgthegpastgmonth.gOngphysicalgexamination,gsheghasgagtemperat
uregofg37.5°C,gandgongauscultationgofgthegchest,gcracklesgaregheardgingallglunggfields.gAgchestgradiographgshowsgmany
gsmall,gill-
definedgnodulargopacitiesgingallglunggfields.gAgtransbronchialgbiopsygspecimengshowsginterstitialginfiltratesgwithglympho
cytes,gplasmagcells,gandgepithelioidgmacrophages.gWhichgofgthegfollowingginfectiousgagentsgisgthegmostglikelygcausego
fgthisgappearance?
□ (A)g Staphylococcusgaureus
□ (B)gPlasmodiumgfalciparum
□ (C)gCandidagalbicans
□ (D)gMycobacteriumgtuberculosis
□ (E)gKlebsiellagpneumoniae
□ (F)gCytomegalovirus
8 Ag36-year-
oldgmanghasghadgmidepigastricgabdominalgpaingforgthegpastg3gmonths.gAngupperggastrointestinalgendoscopygshowsgag
2-
cm,gsharplygdemarcated,gshallowgulcerationgofgtheggastricgantrum.gAgbiopsygspecimengofgthegulcergbasegshowsgangiog
enesis,gfibrosis,gandgmononucleargcellginfiltratesgwithglymphocytes,gmacrophages,gandgplasmagcells.gWhichgofgthegfoll
, Robbinsg&gCotrangReviewgofgPatholog Pg.g20
owinggtermsgbestgdescribesgthisgpathologic
y gprocess?
□ (A)gAcuteginflammation
2. AcutegandgChronicgInflammation y
PBD7gandgPBD8gChapterg2:gAcutegandgChronicgInflammation
BP7gandgBP8gChapterg2:gAcutegandgChronicgInflammation
1 Ingag6-monthgrandomizedgtrialgofgagpharmacologicgagent,goneggroupgofgpatientsgreceivesgagcyclooxygenase-2g(COX-
2)ginhibitor,gandgagcontrolggroupgdoesgnot.gLaboratorygmeasurementsgduringgthegtrialgshowgnogsignificantgdifferencesgbet
weengtheggroupsgingWBCgcount,gplateletgcount,ghemoglobin,gandgcreatinine.gTheggroupgreceivinggthegdruggreportsgs
ubjectivegfindingsgdifferentgfromgthosegofgthegcontrolggroup,ghowever.gWhichgofgthegfollowinggfindingsgwasgmostglikelygre
portedgbygtheggroupgreceivinggthegdrug?
□ (A)gAnklegswelling
□ (B)gIncreasedgboutsgofgasthma
□ (C)gEasygbruisability
□ (D)gReducedgurticaria
□ (E)gIncreasedgfebrilegepisodes
□ (F)gReducedgarthritisgpain
2 Angexperimentgintroducesgbacteriagintogagperfusedgtissuegpreparation.gLeukocytesgleavegthegvasculaturegandgmigrateg
togthegsitegofgbacterialginoculation.gThegmovementgofgthesegleukocytesgisgmostglikelygtogbegmediatedgbygwhichgofgthegfoll
owinggsubstances?
□ (A)gBradykinin
□ (B)gChemokines
□ (C)gHistamine
□ (D)gProstaglandins
□ (E)gComplementgC3a
3 Ag53-year-
oldgwomanghasghadgaghighgfevergandgcoughgproductivegofgyellowishgsputumgforgthegpastg2gdays.gHergvitalgsignsgincludeg
temperaturegofg37.8°C,gpulsegofg83/min,grespirationsgofg17/min,gandgbloodgpressuregofg100/60gmmgHg.gOngausc
ultationgofgthegchest,gcracklesgaregaudiblegingbothglunggbases.gAgchestgradiographgshowsgbilateralgpatchygpulmonarygi
nfiltratesgandgfluidgingthegrightgpleuralgcavity.gThoracentesisgyieldsg500gmLgofgcloudygyellowgfluid.gWhichgofgthegfollowi
ngginflammatorygcellgtypesgisgmostglikelygtogbegseenginggreatlygincreasedgnumbersgingagsputumgspecimen?
□ (A)gMacrophages
□ (B)gNeutrophils
□ (C)gMastgcells
□ (D)gSmallglymphocytes
□ (E)gLanghansggiantgcells
4 Ag63-year-
oldgmangdevelopsgworseninggcongestivegheartgfailureg2gweeksgaftergangacutegmyocardialginfarction.gAngechocardi
ogramgshowsgagmarkedlygdecreasedgejectiongfraction.gHegdiesg1gdayglater.gAtgautopsy,gagsectiongofgtheginfarctgshow
sgthatgthegnecroticgmyocardiumghasglargelygbeengreplacedgbygcapillaries,gfibroblasts,gandgcollagen.gVariousginfl
ammatorygcellsgaregpresent.gWhichgofgthegfollowingginflammatorygcellgtypesgingthisglesiongplaysgthegmostgimportantgrolegin
gtheghealinggprocess?
□ (A)gMacrophages
, Robbinsg&gCotrangReviewgofgPatholog Pg.g18
□ (B)gPlasmagcells y
, Robbinsg&gCotrangReviewgofgPatholog Pg.g19
y
□ (C)gNeutrophils
□ (D)gEosinophils
□ (E)gEpithelioidgcells
5 Ag10-year-
oldgchildgdevelopedgagsoregthroatgandgfevergoverg24ghours.gPhysicalgexaminationgshowsgpharyngealgerythemagandgswe
lling.gLaboratorygfindingsgincludegleukocytosis.gThegchildgisggivengacetylsalicylicgacidg(aspirin).gWhichgofgthegfollow
inggfeaturesgofgtheginflammatorygresponsegisgmostgaffectedgbygthisgdrug?
□ (A)gVasodilation
□ (B)gChemotaxis
□ (C)gPhagocytosis
□ (D)gEmigrationgofgleukocytes
□ (E)gReleasegofgleukocytesgfromgbonegmarrow
6 Agwomangwhogisgallergicgtogcatsgvisitsgagneighborgwhoghasgseveralgcats.gDuringgthegvisit,gsheginhalesgcatgdander,g
andgwithingminutes,gshegdevelopsgnasalgcongestiongwithgabundantgnasalgsecretions.gWhichgofgthegfollowinggsubstancesgi
sgmostglikelygtogproducegthesegfindings?
□ (A)gBradykinin
□ (B)gComplementgC5a
□ (C)gHistamine
□ (D)g Interleukin-1
□ (E)gPhospholipasegC
□ (F)gPlatelet-activatinggfactor
□ (G)gTumorgnecrosisgfactor
7 Ag32-year-
oldgwomanghasghadgagchronicgcoughgwithgfevergforgthegpastgmonth.gOngphysicalgexamination,gsheghasgagtemperat
uregofg37.5°C,gandgongauscultationgofgthegchest,gcracklesgaregheardgingallglunggfields.gAgchestgradiographgshowsgmany
gsmall,gill-
definedgnodulargopacitiesgingallglunggfields.gAgtransbronchialgbiopsygspecimengshowsginterstitialginfiltratesgwithglympho
cytes,gplasmagcells,gandgepithelioidgmacrophages.gWhichgofgthegfollowingginfectiousgagentsgisgthegmostglikelygcausego
fgthisgappearance?
□ (A)g Staphylococcusgaureus
□ (B)gPlasmodiumgfalciparum
□ (C)gCandidagalbicans
□ (D)gMycobacteriumgtuberculosis
□ (E)gKlebsiellagpneumoniae
□ (F)gCytomegalovirus
8 Ag36-year-
oldgmanghasghadgmidepigastricgabdominalgpaingforgthegpastg3gmonths.gAngupperggastrointestinalgendoscopygshowsgag
2-
cm,gsharplygdemarcated,gshallowgulcerationgofgtheggastricgantrum.gAgbiopsygspecimengofgthegulcergbasegshowsgangiog
enesis,gfibrosis,gandgmononucleargcellginfiltratesgwithglymphocytes,gmacrophages,gandgplasmagcells.gWhichgofgthegfoll
, Robbinsg&gCotrangReviewgofgPatholog Pg.g20
owinggtermsgbestgdescribesgthisgpathologic
y gprocess?
□ (A)gAcuteginflammation
