HESI Pharmacology Practice Test
2025/2026 questions with assured
correct answers
The nurse reviews the new prescription, phenelzine (Nardil), a monoamine oxidase inhibitor (MAOI), for
a client with depression on the psychiatric unit. Which information is most important for the nurse to
assess?
A. Consumption of any alcohol or tyramine rich foods
B. Reports of nausea or vomiting
C. Therapeutic serum drug levels
D. Blood pressure and pulse prior to taking each dose - ANSA
The nurse is administering haloperidol 0.5 mg IM PRN to a client for the first time. What side effects
should the nurse assess thr client during the initial dose?
A. Bradykinesia
B. Dystonia
C. Somatization
D. Akathisia - ANSB
While reviewing the client's electronic medical record (EMR), the nurse assesses a client who is at risk
for a possible interaction with an over-the-counter (OTC) decongestant. Which client health history
should the nurse report to the health care provider concerning the OTC medication? (Select all that
apply)
,A. Type 1 diabetes mellitus (DM)
B. Closed angle glaucome
C. Chronic hypertension
D. Rheumatoid arthritis
E. Crohn's disease - ANSB,C
A client prescribed ipratropium reports nausea, blurred vision, headaches, and insomnia after using the
inhaler. Which action should the nurse implement first?
A. Withhold the medication and report symptoms and vital signs to the healthcare provider
B. Give PRN medication for nausea and vomiting and evaluate client in 30 minutes
C. reassure client that the ipratropium given will alleviate the symptoms
D. Delay administration of ipratropium until the next maintenance medication is scheduled - ANSA
A client diagnosed with multiple sclerosis is experiencing profound weakness, blurry vision, and shooting
pains in both legs. Which medication is considered the best course of treatment for the nurse to
administer?
A. High dose methylprednisolone intravenously
B. Baclofen three times a day
C. Broad spectrum antibiotic coverage orally
D. Immunomodulatory drug therapy periodically - ANSA
The nurse administers 30 mL of lactulose for a client with stage 2 hepatic encephalopathy. Which
assessment finding would indicate the medication is being therapeutic?
A. A decrease in blood ammonia levels
B. A softening in the stools
C. An increase in glucose absorption
D. A suppression of gut acidification - ANSA
, The nurse is teaching a client who is newly diagnosed with type 1 diabetes about neutral protamine
Hagedor (NPH) insulin. Which statement by the client indicates an understanding of how the medication
works?
A. It facilitates the transport of glucose into the cells
B. It stimulates the function of beta cells in the pancreas
C. It increases the intracellular receptor site sensitivity
D. It delays the carbohydrate digestion and absorption - ANSA
The nurse should withhold which medication if a client reports nausea, vomiting, and diarrhea?
A. Colchicine (Mitigare, Colcrys)
B. Erythromycin (E-mycin)
C. Naproxen (Aleve, Naprosyn)
D. Labetolol (Normodyne) - ANSA
A client newly prescribed esomeprazole for gastroesophageal reflux disease (GERD) asks the nurse how
the medication will help. Which is the best explanation to provide the client?
A. It will promote rapid tissue healing
B. It will increase gastric emptying
C. It will improve esophageal peristalsis
D. It will neutralize gastric secretions - ANSA
A nurse is providing medication education for a client prescribed a beta-blocking agent for treatment of
glaucoma. Which statement by the client demonstrates an understanding of the mechanism of the
medication?
A. It inhibits the aqueous humor production
2025/2026 questions with assured
correct answers
The nurse reviews the new prescription, phenelzine (Nardil), a monoamine oxidase inhibitor (MAOI), for
a client with depression on the psychiatric unit. Which information is most important for the nurse to
assess?
A. Consumption of any alcohol or tyramine rich foods
B. Reports of nausea or vomiting
C. Therapeutic serum drug levels
D. Blood pressure and pulse prior to taking each dose - ANSA
The nurse is administering haloperidol 0.5 mg IM PRN to a client for the first time. What side effects
should the nurse assess thr client during the initial dose?
A. Bradykinesia
B. Dystonia
C. Somatization
D. Akathisia - ANSB
While reviewing the client's electronic medical record (EMR), the nurse assesses a client who is at risk
for a possible interaction with an over-the-counter (OTC) decongestant. Which client health history
should the nurse report to the health care provider concerning the OTC medication? (Select all that
apply)
,A. Type 1 diabetes mellitus (DM)
B. Closed angle glaucome
C. Chronic hypertension
D. Rheumatoid arthritis
E. Crohn's disease - ANSB,C
A client prescribed ipratropium reports nausea, blurred vision, headaches, and insomnia after using the
inhaler. Which action should the nurse implement first?
A. Withhold the medication and report symptoms and vital signs to the healthcare provider
B. Give PRN medication for nausea and vomiting and evaluate client in 30 minutes
C. reassure client that the ipratropium given will alleviate the symptoms
D. Delay administration of ipratropium until the next maintenance medication is scheduled - ANSA
A client diagnosed with multiple sclerosis is experiencing profound weakness, blurry vision, and shooting
pains in both legs. Which medication is considered the best course of treatment for the nurse to
administer?
A. High dose methylprednisolone intravenously
B. Baclofen three times a day
C. Broad spectrum antibiotic coverage orally
D. Immunomodulatory drug therapy periodically - ANSA
The nurse administers 30 mL of lactulose for a client with stage 2 hepatic encephalopathy. Which
assessment finding would indicate the medication is being therapeutic?
A. A decrease in blood ammonia levels
B. A softening in the stools
C. An increase in glucose absorption
D. A suppression of gut acidification - ANSA
, The nurse is teaching a client who is newly diagnosed with type 1 diabetes about neutral protamine
Hagedor (NPH) insulin. Which statement by the client indicates an understanding of how the medication
works?
A. It facilitates the transport of glucose into the cells
B. It stimulates the function of beta cells in the pancreas
C. It increases the intracellular receptor site sensitivity
D. It delays the carbohydrate digestion and absorption - ANSA
The nurse should withhold which medication if a client reports nausea, vomiting, and diarrhea?
A. Colchicine (Mitigare, Colcrys)
B. Erythromycin (E-mycin)
C. Naproxen (Aleve, Naprosyn)
D. Labetolol (Normodyne) - ANSA
A client newly prescribed esomeprazole for gastroesophageal reflux disease (GERD) asks the nurse how
the medication will help. Which is the best explanation to provide the client?
A. It will promote rapid tissue healing
B. It will increase gastric emptying
C. It will improve esophageal peristalsis
D. It will neutralize gastric secretions - ANSA
A nurse is providing medication education for a client prescribed a beta-blocking agent for treatment of
glaucoma. Which statement by the client demonstrates an understanding of the mechanism of the
medication?
A. It inhibits the aqueous humor production
