NBME 25 REVISION EXAM TEST 2025/2026 QUESTIONS
WITH ANSWERS GRADED A+
✔✔IL-1 fn in bone - ✔✔osteoclast activation (high in osteoporosis)
✔✔V2 receptor type - ✔✔Gs
✔✔V1 receptor type - ✔✔Gq
✔✔sensation in first dorsal web space - ✔✔deep fibular n
✔✔tibial n motor fn - ✔✔posterior compartment of lower leg
✔✔deep fibular n motor fn - ✔✔tibialis anterior
✔✔cardiac structure ant to esophagus - ✔✔LA
✔✔acid-base imbalance w/ vomiting - ✔✔hypokalemia hypochloremic metabolic
acidosis
✔✔alginate - ✔✔polysaccharide present in pseudomonas capsule
✔✔glucuronoxylomannan - ✔✔polysaccharide present in cryptococcus capsule
✔✔hemophagocytic lymphohistiocytosis desc - ✔✔perforin def --> massive immune rxn
✔✔hemophagocytic lymphohistiocytosis si/sx - ✔✔fever, sepsis-like syndrome, death
✔✔complement mutation associated w/ SLE - ✔✔C1q
✔✔thyroid hormone receptor type - ✔✔intracellular (DNA binding)
✔✔retinoic acid receptor type - ✔✔intracellular (DNA binding)
✔✔bartonella histo - ✔✔granulomas w/ stellate microabscesses
✔✔FSH pattern over menstrual cycle - ✔✔inc then gradual dec during follicular phase,
spike @ ovulation,
low during luteal phase
✔✔sx of opioid withdrawal that aren't present in etoh withdrawal - ✔✔lacrimation,
rhinorrhea, piloerection, yawning
, ✔✔thoracocentesis location - ✔✔US-guided preferred,
2 rib spaces below sup border of dullness,
midaxillary if supine, midscapular if upright
✔✔Ca activity in oxidative cell damage - ✔✔inc intracellular Ca --> protease activation
(calpain)
✔✔reye syndrome mech - ✔✔ASA disrupts Box in mito --> fatty liver --> hepatic dysfn
✔✔location of ablation for aflutter - ✔✔b/t IVC and tricuspid
✔✔mixed cryoglobulinemia si/sx - ✔✔fatigue, arthralgias, palpable purpura
✔✔location of ablation for afib - ✔✔pulmonary vv
✔✔mixed cryoglobulinemia assocation - ✔✔hep C
✔✔acute t cell mediated kidney rejection histo - ✔✔lymphocytes in tubules & arterial
walls
✔✔acute b cell mediated kidney rejection histo - ✔✔arteritis, thrombosis, tubular injury
✔✔familial hypercholesterolemia mech - ✔✔dec LDL/cholesterol clearance by liver
✔✔normal JVP - ✔✔8-10
✔✔causes of intrinsic apoptosis - ✔✔cellular damage -- radiation, oxidation, toxins,
ischemia
✔✔causes of extrinsic apoptosis - ✔✔Fas-L, perforin, granzyme (cytotoxic T cells)
✔✔mech of apoptosis in viral hepatitis - ✔✔extrinsic (perforin, granzyme)
✔✔nasal decongestant MOA - ✔✔a1 agonists
✔✔bosentan MOA - ✔✔endothelin-1 antagonist
✔✔bosentan use - ✔✔primary pulmonary arterial HTN
✔✔MCC iatrogenic chylothorax - ✔✔central line placement via L internal jugular v
✔✔MCC acute TIN - ✔✔drug hypersensitivity
WITH ANSWERS GRADED A+
✔✔IL-1 fn in bone - ✔✔osteoclast activation (high in osteoporosis)
✔✔V2 receptor type - ✔✔Gs
✔✔V1 receptor type - ✔✔Gq
✔✔sensation in first dorsal web space - ✔✔deep fibular n
✔✔tibial n motor fn - ✔✔posterior compartment of lower leg
✔✔deep fibular n motor fn - ✔✔tibialis anterior
✔✔cardiac structure ant to esophagus - ✔✔LA
✔✔acid-base imbalance w/ vomiting - ✔✔hypokalemia hypochloremic metabolic
acidosis
✔✔alginate - ✔✔polysaccharide present in pseudomonas capsule
✔✔glucuronoxylomannan - ✔✔polysaccharide present in cryptococcus capsule
✔✔hemophagocytic lymphohistiocytosis desc - ✔✔perforin def --> massive immune rxn
✔✔hemophagocytic lymphohistiocytosis si/sx - ✔✔fever, sepsis-like syndrome, death
✔✔complement mutation associated w/ SLE - ✔✔C1q
✔✔thyroid hormone receptor type - ✔✔intracellular (DNA binding)
✔✔retinoic acid receptor type - ✔✔intracellular (DNA binding)
✔✔bartonella histo - ✔✔granulomas w/ stellate microabscesses
✔✔FSH pattern over menstrual cycle - ✔✔inc then gradual dec during follicular phase,
spike @ ovulation,
low during luteal phase
✔✔sx of opioid withdrawal that aren't present in etoh withdrawal - ✔✔lacrimation,
rhinorrhea, piloerection, yawning
, ✔✔thoracocentesis location - ✔✔US-guided preferred,
2 rib spaces below sup border of dullness,
midaxillary if supine, midscapular if upright
✔✔Ca activity in oxidative cell damage - ✔✔inc intracellular Ca --> protease activation
(calpain)
✔✔reye syndrome mech - ✔✔ASA disrupts Box in mito --> fatty liver --> hepatic dysfn
✔✔location of ablation for aflutter - ✔✔b/t IVC and tricuspid
✔✔mixed cryoglobulinemia si/sx - ✔✔fatigue, arthralgias, palpable purpura
✔✔location of ablation for afib - ✔✔pulmonary vv
✔✔mixed cryoglobulinemia assocation - ✔✔hep C
✔✔acute t cell mediated kidney rejection histo - ✔✔lymphocytes in tubules & arterial
walls
✔✔acute b cell mediated kidney rejection histo - ✔✔arteritis, thrombosis, tubular injury
✔✔familial hypercholesterolemia mech - ✔✔dec LDL/cholesterol clearance by liver
✔✔normal JVP - ✔✔8-10
✔✔causes of intrinsic apoptosis - ✔✔cellular damage -- radiation, oxidation, toxins,
ischemia
✔✔causes of extrinsic apoptosis - ✔✔Fas-L, perforin, granzyme (cytotoxic T cells)
✔✔mech of apoptosis in viral hepatitis - ✔✔extrinsic (perforin, granzyme)
✔✔nasal decongestant MOA - ✔✔a1 agonists
✔✔bosentan MOA - ✔✔endothelin-1 antagonist
✔✔bosentan use - ✔✔primary pulmonary arterial HTN
✔✔MCC iatrogenic chylothorax - ✔✔central line placement via L internal jugular v
✔✔MCC acute TIN - ✔✔drug hypersensitivity
