PC707: Final Exam
Study online at https://quizlet.com/_ep7974
1. What class of medication can cause tooth Tetracycline antibiotics
discoloration, deposits on bones, and
bone growth restriction?
2. What are the risks to a postpartum moth- opioid toxicity
er and newborn if the mother is an ul-
tra-rapid metabolizer taking codeine? *in ultrarapid metabolizers, there may be an
increase in morphine from codeine, result-
ing in opioid toxicity.
3. Combined oral contraceptives increase theophylline
blood levels of _____________________, valium
_____________________, _______________, and TCA's
________________. Lithium
4. Grapefruit juice is a CYP450 ____________, inhibitor
and leads to ______________ pharmacologic increased
effect of drugs.
5. What electrolyte do you need to moni- Potassium
tor while a patient is taking Drospirenone
(COC)? It also interacts with other K+ sparing drugs,
causing hyperkalemia (ACEi, ARBs, K+ sparin
diuretics, NSAIDs)
6. Iron supplementation is contraindicated children <6 years
in whom?
overdose is fatal
7. What are the risks to a pregnant woman Hypertension
who takes an NSAID? (2 listed) bleeding at delivery
8. What are the risks to a fetus if the mother premature closure of DA
takes an NSAID? (2 listed) may cause GI bleeds
, PC707: Final Exam
Study online at https://quizlet.com/_ep7974
9. Probiotic use is contraindicated in whom? immunocompromised individuals
10. What fatal rhythm is the risk when taking torsades
a medication that causes a QT prolonga-
tion?
11. T/F: A 30-year old woman with hyperlipi- False
demia can safely continue to take her
statin when pregnant. *Statins are teratogenic in pregnancy
12. Excessive intake of what vitamin is terato- Vitamin A/Retinoic Acid
genic in pregnancy?
13. What is the black box warning for fluoro- tendon rupture
quinolones?
14. fluoroquinolones should not be pre- aortic aneurysm
scribed for patients with peripheral ath-
erosclerotic vascular disease, HTN, Mar-
fan's syndrome and the elderly d/t the in-
creased risk of what?
15. Clarithromycin (Biaxin) should not be tak- lovastatin
en with what two HMG-CoA reductase in- simvastatin
hibitors (statins)?
16. Live vaccines are contraindicated in pregnancy
___________, children <______ years old, and children <12 years old
_____________________ individuals. immunocompromised
17. Clients at high risk for low B6 (HIV, DM, Isoniazid (INH)
RF, Alcoholics, pregnant/lactating women)
, PC707: Final Exam
Study online at https://quizlet.com/_ep7974
should take supplemental vitamin B6 * also need backup contraceptive while us-
when taking what drug? ing INH
18. When taking Isoniazid (INH), patients at B6
risk of what vitamin deficiency should sup-
plement with it? * also need backup contraceptive while us-
ing INH
19. Why is Macrobid contraindicated in the Can cause hemolytic anemia of the newborn
third trimester and during labor?
20. T/F: Macrolides "mycins" can cause QT pro- True
longation.
21. Clients taking metronidazole (Flagyl) must alcohol (includes cough syrup and alcohol
be cautioned to avoid ___________ during based herbals)
treatment and for 24-48 hours after the
last dose.
22. taking oral antifungals during pregnancy congenital anomalies
can cause what?
23. Use of Sulfonamides during pregnancy cardiovascular defects
can lead to what 4 adverse effects to the oral cleft defects
fetus? hyperbilirubinemia
kernicterus
24. Use of Trimethoprim-Sulfamethoxazole ACEi
(TMP-SMX) is contraindicated when using ARBs
what two classes of anti-hypertensives?
Why? increased risk of hyperkalemia and sudden
cardiac death (especially in elderly or pt's
with kidney disease)
, PC707: Final Exam
Study online at https://quizlet.com/_ep7974
25. Trimethoprim-sulfamethoxazole Hypokalemia
(TMP-SMX) use is associated with what
electrolyte deficiency when used alone?
26. What class of antibiotics is associated with Sulfonamides
bilateral hearing loss that is reversible in
24 hours-2 weeks?
27. Bismuth Subsalicylate (Pepto-Bismol) con- aspirin
tains _________________ and is contraindi-
cated in _____________, _______________, and pregnancy, lactation, children <12 years
________________.
*can cause Reye's Syndrome
28. Cimetidine (Tagamet) can cause what two gynecomastia
issues for men? impotence
29. What is the black box warning for Metoclo- tardive dyskinesia with chronic use
pramide (Reglan)?
*do not use >12 weeks if possible
30. Use of PPI's can cause deficiencies in what B12
3 vitamins? calcium
magnesium
31. Chronic use of ________ can increase the PPI's
risk of fractures and cause hyperplasia of
the stomach lining (pre-condition of gas-
tric carcinoid).
32. What is the black box warning for Promet- fatal respiratory depression in children
hazine (antiemetic)?
33.
Study online at https://quizlet.com/_ep7974
1. What class of medication can cause tooth Tetracycline antibiotics
discoloration, deposits on bones, and
bone growth restriction?
2. What are the risks to a postpartum moth- opioid toxicity
er and newborn if the mother is an ul-
tra-rapid metabolizer taking codeine? *in ultrarapid metabolizers, there may be an
increase in morphine from codeine, result-
ing in opioid toxicity.
3. Combined oral contraceptives increase theophylline
blood levels of _____________________, valium
_____________________, _______________, and TCA's
________________. Lithium
4. Grapefruit juice is a CYP450 ____________, inhibitor
and leads to ______________ pharmacologic increased
effect of drugs.
5. What electrolyte do you need to moni- Potassium
tor while a patient is taking Drospirenone
(COC)? It also interacts with other K+ sparing drugs,
causing hyperkalemia (ACEi, ARBs, K+ sparin
diuretics, NSAIDs)
6. Iron supplementation is contraindicated children <6 years
in whom?
overdose is fatal
7. What are the risks to a pregnant woman Hypertension
who takes an NSAID? (2 listed) bleeding at delivery
8. What are the risks to a fetus if the mother premature closure of DA
takes an NSAID? (2 listed) may cause GI bleeds
, PC707: Final Exam
Study online at https://quizlet.com/_ep7974
9. Probiotic use is contraindicated in whom? immunocompromised individuals
10. What fatal rhythm is the risk when taking torsades
a medication that causes a QT prolonga-
tion?
11. T/F: A 30-year old woman with hyperlipi- False
demia can safely continue to take her
statin when pregnant. *Statins are teratogenic in pregnancy
12. Excessive intake of what vitamin is terato- Vitamin A/Retinoic Acid
genic in pregnancy?
13. What is the black box warning for fluoro- tendon rupture
quinolones?
14. fluoroquinolones should not be pre- aortic aneurysm
scribed for patients with peripheral ath-
erosclerotic vascular disease, HTN, Mar-
fan's syndrome and the elderly d/t the in-
creased risk of what?
15. Clarithromycin (Biaxin) should not be tak- lovastatin
en with what two HMG-CoA reductase in- simvastatin
hibitors (statins)?
16. Live vaccines are contraindicated in pregnancy
___________, children <______ years old, and children <12 years old
_____________________ individuals. immunocompromised
17. Clients at high risk for low B6 (HIV, DM, Isoniazid (INH)
RF, Alcoholics, pregnant/lactating women)
, PC707: Final Exam
Study online at https://quizlet.com/_ep7974
should take supplemental vitamin B6 * also need backup contraceptive while us-
when taking what drug? ing INH
18. When taking Isoniazid (INH), patients at B6
risk of what vitamin deficiency should sup-
plement with it? * also need backup contraceptive while us-
ing INH
19. Why is Macrobid contraindicated in the Can cause hemolytic anemia of the newborn
third trimester and during labor?
20. T/F: Macrolides "mycins" can cause QT pro- True
longation.
21. Clients taking metronidazole (Flagyl) must alcohol (includes cough syrup and alcohol
be cautioned to avoid ___________ during based herbals)
treatment and for 24-48 hours after the
last dose.
22. taking oral antifungals during pregnancy congenital anomalies
can cause what?
23. Use of Sulfonamides during pregnancy cardiovascular defects
can lead to what 4 adverse effects to the oral cleft defects
fetus? hyperbilirubinemia
kernicterus
24. Use of Trimethoprim-Sulfamethoxazole ACEi
(TMP-SMX) is contraindicated when using ARBs
what two classes of anti-hypertensives?
Why? increased risk of hyperkalemia and sudden
cardiac death (especially in elderly or pt's
with kidney disease)
, PC707: Final Exam
Study online at https://quizlet.com/_ep7974
25. Trimethoprim-sulfamethoxazole Hypokalemia
(TMP-SMX) use is associated with what
electrolyte deficiency when used alone?
26. What class of antibiotics is associated with Sulfonamides
bilateral hearing loss that is reversible in
24 hours-2 weeks?
27. Bismuth Subsalicylate (Pepto-Bismol) con- aspirin
tains _________________ and is contraindi-
cated in _____________, _______________, and pregnancy, lactation, children <12 years
________________.
*can cause Reye's Syndrome
28. Cimetidine (Tagamet) can cause what two gynecomastia
issues for men? impotence
29. What is the black box warning for Metoclo- tardive dyskinesia with chronic use
pramide (Reglan)?
*do not use >12 weeks if possible
30. Use of PPI's can cause deficiencies in what B12
3 vitamins? calcium
magnesium
31. Chronic use of ________ can increase the PPI's
risk of fractures and cause hyperplasia of
the stomach lining (pre-condition of gas-
tric carcinoid).
32. What is the black box warning for Promet- fatal respiratory depression in children
hazine (antiemetic)?
33.
