, Test Bank
v
to vaccompany
Psychopharmacology, Third Editionv v
Meyer v• vQuenzer
Chapter 1: Principles of Pharmacology
v v v v
Multiple vChoice
1. refer(s) vto vspecific vmolecular vchanges vthat voccur vwhen va vdrug vbinds vto va
vparticular vtarget vsite vor vreceptor, vwhile are vthe vresulting vwidespread valterations
vin vfunction.
a. Drug vaction; vtherapeutic veffects
b. Side veffects; vdrug veffects
c. Therapeutic veffects; vside veffects
d. Drug vaction; vdrug veffects
Answer: vd
Textbook vReference: vPharmacology: vThe vScience vof vDrug vAction
2. After vdrug vadministration vhas voccurred, vthe vamount vof vdrug vin vthe vblood vthat vis vfree
vto vbind vat vspecific vtarget vsites vis vreferred vto vas
a. the vtherapeutic vdose.
b. first-pass veffects.
c. bioavailability.
d. ED50.
Answer: vc
Textbook vReference: vPharmacokinetic vFactors vDetermining vDrug vAction
3. The vspecific vmolecular vchanges vthat voccur vwhen va vdrug vbinds vto va vparticular vtarget
vsite vor vreceptor vare vreferred vto vas
a. drug veffects.
b. drug vaction.
c. side veffects.
d. placebo veffects.
Answer: vb
Textbook vReference: vPharmacology: vThe vScience vof vDrug vAction
4. Which vof vthe vfollowing vis vnot va vpossible vexplanation vfor vplacebo veffects?
a. Pavlovian vconditioning
b. Genetic vvariation
c. Drug vcompetition
d. Expectation vof voutcome
Answer: vc
Textbook vReference: vPharmacology: vThe vScience vof vDrug vAction
Page v1 vof v247
,5. The administration vof voxytocin vhas vbeen vproposed vas va vtreatment vfor vautism.
a. intravenous
b. oral
c. intranasal
d. intracerebral
Answer: vc
Textbook vReference: vPharmacokinetic vFactors vDetermining vDrug vAction
6. Which vfactor vdoes vnot vaffect vthe vpharmacokinetics vof va vdrug?
a. Route vof vadministration
b. Lipid vsolubility
c. Depot vbinding
d. Drug vaction
Answer: vd
Textbook vReference: vPharmacokinetic vFactors vDetermining vDrug vAction
7. First-pass vmetabolism voccurs vwhen vdrugs vare vtaken
a. orally.
b. intravenously.
c. subcutaneously.
d. nasally.
Answer: va
Textbook vReference: vPharmacokinetic vFactors vDetermining vDrug vAction
8. The varea vpostrema vis vone varea vin vthe vbrain vwhere vthe is vnot vcomplete.
a. cerebrospinal vfluid
b. blood–brain vbarrier
c. choroid vplexus
d. phospholipid vmembrane
Answer: vb
Textbook vReference: vPharmacokinetic vFactors vDetermining vDrug vAction
9. First-pass vmetabolism voccurs vwith vorally vadministered vdrugs vbecause
a. their vabsorption vis vslowed vby vfood.
b. drugs vabsorbed vinto vthe vbloodstream vfrom vthe vstomach vgo vto vthe vliver von vthe vway
vto vgeneral vcirculation.
c. drugs vmust vfirst vsurvive vthe vacidic venvironment vof vthe vstomach.
d. salivary venzymes vin vthe vmouth vbegin vthe vprocess vof vmetabolism.
Answer: vb
Textbook vReference: vPharmacokinetic vFactors vDetermining vDrug vAction
10. Toxic vsubstances vin vthe vblood vtrigger va vvomiting vresponse vby vactivating vthe
a. blood–brain vbarrier.
b. choroid vplexus.
c. area vpostrema.
d. median veminence.
Page v2 vof v247
, Answer: vc
Textbook vReference: vPharmacokinetic vFactors vDetermining vDrug vAction
11. Drugs vadministered v_ have vthe vmost vrapid vonset vof vaction.
a. subcutaneously
b. intramuscularly
c. orally
d. intravenously
Answer: vd
Textbook vReference: vPharmacokinetic vFactors vDetermining vDrug vAction
12. Ionization vof va vdrug vdepends von vthe of vthe vsolution vand vthe of vthe
vdrug.
a. pH; vpKa
b. pKa; vpH
c. concentration; vlipid vsolubility
d. pH; vconcentration
Answer: va
Textbook vReference: vPharmacokinetic vFactors vDetermining vDrug vAction
13. The vabsorption vof va vdrug vdepends von vall vof vthe vfollowing vexcept
a. lipid vsolubility.
b. ionization.
c. body vtemperature.
d. the vconcentration vof vthe vdrug.
Answer: vc
Textbook vReference: vPharmacokinetic vFactors vDetermining vDrug vAction
14. Drugs vthat vare should vbe vavoided vby vwomen vof vchildbearing vage.
a. teratogenic
b. able vto vcross vthe vplacental vbarrier
c. psychoactive
d. highly vlipid-soluble
Answer: va
Textbook vReference: vPharmacokinetic vFactors vDetermining vDrug vAction
15. Agents vthat vinduce vdevelopmental vabnormalities vin va vfetus vare vknown vas
a. psychoactive vdrugs.
b. illicit vdrugs.
c. teratogens.
d. placental vdrugs.
Answer: vc
Textbook vReference: vPharmacokinetic vFactors vDetermining vDrug vAction
16. Depot vbinding vis vsaid vto voccur vwhen vdrugs
a. bind vto vtheir vtarget vsites.
Page v3 vof v247
v
to vaccompany
Psychopharmacology, Third Editionv v
Meyer v• vQuenzer
Chapter 1: Principles of Pharmacology
v v v v
Multiple vChoice
1. refer(s) vto vspecific vmolecular vchanges vthat voccur vwhen va vdrug vbinds vto va
vparticular vtarget vsite vor vreceptor, vwhile are vthe vresulting vwidespread valterations
vin vfunction.
a. Drug vaction; vtherapeutic veffects
b. Side veffects; vdrug veffects
c. Therapeutic veffects; vside veffects
d. Drug vaction; vdrug veffects
Answer: vd
Textbook vReference: vPharmacology: vThe vScience vof vDrug vAction
2. After vdrug vadministration vhas voccurred, vthe vamount vof vdrug vin vthe vblood vthat vis vfree
vto vbind vat vspecific vtarget vsites vis vreferred vto vas
a. the vtherapeutic vdose.
b. first-pass veffects.
c. bioavailability.
d. ED50.
Answer: vc
Textbook vReference: vPharmacokinetic vFactors vDetermining vDrug vAction
3. The vspecific vmolecular vchanges vthat voccur vwhen va vdrug vbinds vto va vparticular vtarget
vsite vor vreceptor vare vreferred vto vas
a. drug veffects.
b. drug vaction.
c. side veffects.
d. placebo veffects.
Answer: vb
Textbook vReference: vPharmacology: vThe vScience vof vDrug vAction
4. Which vof vthe vfollowing vis vnot va vpossible vexplanation vfor vplacebo veffects?
a. Pavlovian vconditioning
b. Genetic vvariation
c. Drug vcompetition
d. Expectation vof voutcome
Answer: vc
Textbook vReference: vPharmacology: vThe vScience vof vDrug vAction
Page v1 vof v247
,5. The administration vof voxytocin vhas vbeen vproposed vas va vtreatment vfor vautism.
a. intravenous
b. oral
c. intranasal
d. intracerebral
Answer: vc
Textbook vReference: vPharmacokinetic vFactors vDetermining vDrug vAction
6. Which vfactor vdoes vnot vaffect vthe vpharmacokinetics vof va vdrug?
a. Route vof vadministration
b. Lipid vsolubility
c. Depot vbinding
d. Drug vaction
Answer: vd
Textbook vReference: vPharmacokinetic vFactors vDetermining vDrug vAction
7. First-pass vmetabolism voccurs vwhen vdrugs vare vtaken
a. orally.
b. intravenously.
c. subcutaneously.
d. nasally.
Answer: va
Textbook vReference: vPharmacokinetic vFactors vDetermining vDrug vAction
8. The varea vpostrema vis vone varea vin vthe vbrain vwhere vthe is vnot vcomplete.
a. cerebrospinal vfluid
b. blood–brain vbarrier
c. choroid vplexus
d. phospholipid vmembrane
Answer: vb
Textbook vReference: vPharmacokinetic vFactors vDetermining vDrug vAction
9. First-pass vmetabolism voccurs vwith vorally vadministered vdrugs vbecause
a. their vabsorption vis vslowed vby vfood.
b. drugs vabsorbed vinto vthe vbloodstream vfrom vthe vstomach vgo vto vthe vliver von vthe vway
vto vgeneral vcirculation.
c. drugs vmust vfirst vsurvive vthe vacidic venvironment vof vthe vstomach.
d. salivary venzymes vin vthe vmouth vbegin vthe vprocess vof vmetabolism.
Answer: vb
Textbook vReference: vPharmacokinetic vFactors vDetermining vDrug vAction
10. Toxic vsubstances vin vthe vblood vtrigger va vvomiting vresponse vby vactivating vthe
a. blood–brain vbarrier.
b. choroid vplexus.
c. area vpostrema.
d. median veminence.
Page v2 vof v247
, Answer: vc
Textbook vReference: vPharmacokinetic vFactors vDetermining vDrug vAction
11. Drugs vadministered v_ have vthe vmost vrapid vonset vof vaction.
a. subcutaneously
b. intramuscularly
c. orally
d. intravenously
Answer: vd
Textbook vReference: vPharmacokinetic vFactors vDetermining vDrug vAction
12. Ionization vof va vdrug vdepends von vthe of vthe vsolution vand vthe of vthe
vdrug.
a. pH; vpKa
b. pKa; vpH
c. concentration; vlipid vsolubility
d. pH; vconcentration
Answer: va
Textbook vReference: vPharmacokinetic vFactors vDetermining vDrug vAction
13. The vabsorption vof va vdrug vdepends von vall vof vthe vfollowing vexcept
a. lipid vsolubility.
b. ionization.
c. body vtemperature.
d. the vconcentration vof vthe vdrug.
Answer: vc
Textbook vReference: vPharmacokinetic vFactors vDetermining vDrug vAction
14. Drugs vthat vare should vbe vavoided vby vwomen vof vchildbearing vage.
a. teratogenic
b. able vto vcross vthe vplacental vbarrier
c. psychoactive
d. highly vlipid-soluble
Answer: va
Textbook vReference: vPharmacokinetic vFactors vDetermining vDrug vAction
15. Agents vthat vinduce vdevelopmental vabnormalities vin va vfetus vare vknown vas
a. psychoactive vdrugs.
b. illicit vdrugs.
c. teratogens.
d. placental vdrugs.
Answer: vc
Textbook vReference: vPharmacokinetic vFactors vDetermining vDrug vAction
16. Depot vbinding vis vsaid vto voccur vwhen vdrugs
a. bind vto vtheir vtarget vsites.
Page v3 vof v247
