Gluconeogenesis Cell Metabolism MCAT Study Guide

Glucose Gluconeogenesis
Pi
Let’s Practice! Glucose-6-phosphatase
Memorize H2O

gluconeogenesis! Glucose-6-phosphate
Phosphohexose Isomerase


Fructose-6-phosphate
NET PRODUCTS
Pi Fructose 1,6-bisphosphatase
H2O
1 Glucose
4 ATP Fructose-1,6-phosphate
2 GDP Aldolase
6 Pi
2 NAD+ Isomerase
Glyceraldehyde Dihydroxyacetone
3-phosphate (2) phosphate
2NAD+ + 2Pi Glyceraldehyde-3-phosphate
2NADH + 2H+ dehydrogenase

1,3-Biphosphoglycerate (2)
2 ADP
Phosphoglycerate kinase
2 ATP

3-Phosphoglycerate (2)
Phosphoglycerate mutase


2-Phosphoglycerate (2)
Enolase

PEPCK 2 GDP
Phosphoenolpyruvate (2) 2 GTP

Oxaloacetate (2)
2 ADP
Pyruvate (2)
2 ATP
Pyruvate carboxylase

, _
Glucose Gluconeogenesis
Pi
Let’s Practice! Glucose-6-phosphatase
Fill in the H2O

steps _
Glucose-6-phosphate
Phosphohexose Isomerase


_
Fructose-6-phosphate
NET PRODUCTS
Pi Fructose 1,6-bisphosphatase
H2O
1 Glucose
4 ATP _Fructose-1,6-phosphate
2 GDP Aldolase
6 Pi
2 NAD+ Isomerase
_Glyceraldehyde _Dihydroxyacetone
Dihydroxyacetone
3-phosphate (2) _phosphate
phosphate
2NAD+ + 2Pi Glyceraldehyde-3-phosphate
2NADH + 2H+ dehydrogenase

_1,3-Biphosphoglycerate (2)
2 ADP
Phosphoglycerate kinase
2 ATP

_
3-Phosphoglycerate (2)
Phosphoglycerate mutase


_2-Phosphoglycerate (2)
Enolase

PEPCK 2 GDP
_
Phosphoenolpyruvate (2) 2 GTP

_
Oxaloacetate (2)
2 ADP
_Pyruvate (2)
2 ATP
Pyruvate carboxylase