TESTbBANKbFORbUNDERSTANDINGbPATHOPHYSIOLOGY
Huether & McCance: Understanding Pathophysiology, 6th Edition
b b b b b b
Chapter 01: Cellular Biology
b b b
MULTIPLEbCHOICE
1. Abstudentbisbobservingbabcellbunderbthebmicroscope.bItbisbobservedbtobhavebsupercoiledbDNAb
withbhistones.bWhichbofbthebfollowingbwouldbalsobbebobservedbbybthebstudent?
a. Absinglebcircularbchromosome
b. Abnucleus
c. Free-floatingbnuclearbmaterial
d. Noborganelles
ANS:b B
Thebcellbdescribedbisbabeukaryoticbcell,bsobitbhasbhistonesbandbabsupercoiledbDNAbwithinbitsbnucl
eus;bthus,bthebnucleusbshouldbbebobserved.bAbsinglebcircularbchromosomebcalledbabprokaryotebc
ontainsbfree-floatingbnuclearbmaterialbbutbhasbnoborganelles.
REF:b p.b2
2. Abnursebisbinstructingbthebstaffbaboutbcellularbfunctions.bWhichbcellularbfunctionbisbthebnursebd
escribingbwhenbanbisolatedbcellbabsorbsboxygenbandbusesbitbtobtransformbnutrientsbtobenergy?
a. Metabolicbabsorption
b. Communication
c. Secretion
d. Respiration
ANS:b D
Thebcell’sbabilitybtobabsorbboxygenbisbreferredbtobasbrespirationbwhilebitsbcommunicationbabilitybinvol
vesbmaintenancebofbabsteadybdynamicbstate,bmetabolicbabsorptionbprovidesbnutrition,bandbsecretionba
llowsbforbthebsynthesizingbofbnewbsubstances.
REF:b p.b2
3. AbeukaryoticbcellbisbundergoingbDNAbreplication.bInbwhichbregionbofbthebcellbwouldbmostbofbt
hebgeneticbinformationbbebcontained?
a. Mitochondria
b. Ribosome
c. Nucleolus
d. NucleusbCytoplasm
ANS:b C
Thebregionbofbthebcellbthatbcontainsbgeneticbmaterial,bincludingbablargebamountbofbribonucleicbaci
d,bmostbofbthebDNA,bandbDNA-
bindingbproteins,bisbthebnucleolus,bwhichbisblocatedbwithinbthebcell’sbnucleus.bMitochondriabisba
ssociatedbwithbcellularbrespiration,bwhilebribosomesbarebinvolvedbwithbproteinbmanufacturing.b
Cytoplasmbisbabfluidbfillingbthatbisbabcomponentbofbthebcell.
REF:b p.b2
,TESTbBANKbFORbUNDERSTANDINGbPATHOPHYSIOLOGY
Huether & McCance: Understanding Pathophysiology, 6th Edition
b b b b b b
Chapter 01: Cellular Biology
b b b
4. Whichbofbthebfollowingbcanbremovebproteinsbattachedbtobthebcell’sbbilayerbbybdissolvingbthebl
ayerbitself?
a. Peripheralbmembranebproteins
b. Integralbmembranebproteins
c. Glycoproteins
d. Cellbadhesionbmolecules
ANS:b B
Proteinsbdirectlybattachedbtobthebmembranebbilayerbcanbbebremovedbbybthebactionbofbintegralbme
mbranebproteinsbthatbdissolvebthebbilayer.bPeripheralbmembranebproteinsbresidebatbthebsurfacebw
hilebcellbadhesionbmoleculesbarebonbtheboutsidebofbthebmembrane.bGlycoproteinbmarksbcellsband
bdoesbnotbfloat.
REF:b p.b7
5. Whichbofbthebfollowingbcanbbindbtobplasmabmembranebreceptors?
a. Oxygen
b. Ribosomes
c. Amphipathicblipids
d. Ligands
ANS:b D
Ligandsbarebthebonlybspecificbmoleculesbthatbcanbbindbwithbreceptorsbonbthebcellbmembrane.
REF:b p.b9
6. Abnursebisbreviewingbabreportbfrombabpatientbwithbmetastaticbcancer.bWhatbalternationbinbthebe
xtracellularbmatrixbwouldbs uNp p oR hIbeTbdG
Ur btSbtbN iagnBo.
siC
sbofM
metastaticbcancer?
a. Decreasedbfibronectin
b. Increasedbcollagen
c. Decreasedbelastin
d. Increasedbglycoproteins
ANS:b A
Onlybabreducedbamountbofbfibronectinbisbfoundbinbsomebtypesbofbcancerousbcells,ballowingbthemb
tobtravelborbmetastasize.
REF:b p.b10
7. Whichbformbofbcellbcommunicationbisbusedbtobrelatebtobotherbcellsbinbdirectbphysicalbcontact?
a. Cellbjunction
b. Gapbjunction
c. Desmosome
d. Tightbjunction
ANS:b A
Cellbjunctionsbholdbcellsbtogetherbandbpermitbmoleculesbtobpassbfrombcellbtobcell.
Gapbjunctionsballowbforbcellularbcommunicationbbetweenbcells.bNeitherbdesmosomesbnorbtightbjuncti
onsbarebassociatedbwithbcellularbcommunication.
REF:b p.b11
,TESTbBANKbFORbUNDERSTANDINGbPATHOPHYSIOLOGY
Huether & McCance: Understanding Pathophysiology, 6th Edition
b b b b b b
Chapter 01: Cellular Biology
b b b
8. Pancreaticbbetabcellsbsecretebinsulin,bwhichbinhibitsbsecretionbofbglucagonbfrombneighboringb
alphabcells.bThisbactionbisbanbexamplebofbwhichbofbthebfollowingbsignalingbtypes?
a. Paracrine
b. Autocrine
c. Neurohormonal
d. Hormonal
ANS:b A
Paracrinebsignalingbinvolvesbthebreleasebofblocalbchemicalbmediatorsbthatbarebquicklybtakenbup,bd
estroyed,borbimmobilized,basbinbthebcasebofbinsulinbandbthebinhibitionbofbthebsecretionbofbglucago
n.bNonebofbthebotherboptionsbinvolvebsignalingbthatbisbassociatedbwithbablocalbchemicalbmediatorb
likebinsulin.
REF:b p.b12
9. Inbcellularbmetabolism,beachbenzymebhasbabhighbaffinitybforba:
a. solute.
b. substrate.
c. receptor.
d. ribosome.
ANS:b B
Eachbenzymebhasbabhighbaffinitybforbabsubstrate,babspecificbsubstancebconvertedbtobabproductbofbt
hebreaction.bCellularbmetabolismbisbnotbdependentbonbanbattractionbbetweenbanbenzymebandbany
bofbthebremainingboptions.
REF:b b p.b16
10. Anbathletebrunsbabmarathon,bafterbwhichbhisbmusclesbfeelbfatiguedbandbunablebtobcontract.bThebat
hletebasksbthebnursebwhybthisbhappened.bThebnurse’sbresponsebisbbasedbonbthebknowledgebthatbthe
bproblembisbresult bofbabdeficiencybof:
a. GTP
b. AMP
c. ATP
d. GMP
ANS:b C
WhenbATPbisbdeficient,bimpairedbmusclebcontractionbresults.bNonebofbthebotherboptionsbarebinvo
lvedbinbmusclebcontraction.
REF:b p.b16
11. WhichbphasebofbcatabolismbproducesbthebmostbATP?
a. Digestion
b. Glycolysis
c. Oxidation
d. Citricbacidbcycle
ANS:b D
WhilebsomebATPbisbproducedbduringbtheboxidationbandbglycolysisbphases,bmostbofbthebATPbis
, TESTbBANKbFORbUNDERSTANDINGbPATHOPHYSIOLOGY
Huether & McCance: Understanding Pathophysiology, 6th Edition
b b b b b b b
Chapter 01: Cellular Biology
b b b
generatedbduringbthebcitricbacidbcycle.bDigestionbdoesbnotbproducebanybATP.
Huether & McCance: Understanding Pathophysiology, 6th Edition
b b b b b b
Chapter 01: Cellular Biology
b b b
MULTIPLEbCHOICE
1. Abstudentbisbobservingbabcellbunderbthebmicroscope.bItbisbobservedbtobhavebsupercoiledbDNAb
withbhistones.bWhichbofbthebfollowingbwouldbalsobbebobservedbbybthebstudent?
a. Absinglebcircularbchromosome
b. Abnucleus
c. Free-floatingbnuclearbmaterial
d. Noborganelles
ANS:b B
Thebcellbdescribedbisbabeukaryoticbcell,bsobitbhasbhistonesbandbabsupercoiledbDNAbwithinbitsbnucl
eus;bthus,bthebnucleusbshouldbbebobserved.bAbsinglebcircularbchromosomebcalledbabprokaryotebc
ontainsbfree-floatingbnuclearbmaterialbbutbhasbnoborganelles.
REF:b p.b2
2. Abnursebisbinstructingbthebstaffbaboutbcellularbfunctions.bWhichbcellularbfunctionbisbthebnursebd
escribingbwhenbanbisolatedbcellbabsorbsboxygenbandbusesbitbtobtransformbnutrientsbtobenergy?
a. Metabolicbabsorption
b. Communication
c. Secretion
d. Respiration
ANS:b D
Thebcell’sbabilitybtobabsorbboxygenbisbreferredbtobasbrespirationbwhilebitsbcommunicationbabilitybinvol
vesbmaintenancebofbabsteadybdynamicbstate,bmetabolicbabsorptionbprovidesbnutrition,bandbsecretionba
llowsbforbthebsynthesizingbofbnewbsubstances.
REF:b p.b2
3. AbeukaryoticbcellbisbundergoingbDNAbreplication.bInbwhichbregionbofbthebcellbwouldbmostbofbt
hebgeneticbinformationbbebcontained?
a. Mitochondria
b. Ribosome
c. Nucleolus
d. NucleusbCytoplasm
ANS:b C
Thebregionbofbthebcellbthatbcontainsbgeneticbmaterial,bincludingbablargebamountbofbribonucleicbaci
d,bmostbofbthebDNA,bandbDNA-
bindingbproteins,bisbthebnucleolus,bwhichbisblocatedbwithinbthebcell’sbnucleus.bMitochondriabisba
ssociatedbwithbcellularbrespiration,bwhilebribosomesbarebinvolvedbwithbproteinbmanufacturing.b
Cytoplasmbisbabfluidbfillingbthatbisbabcomponentbofbthebcell.
REF:b p.b2
,TESTbBANKbFORbUNDERSTANDINGbPATHOPHYSIOLOGY
Huether & McCance: Understanding Pathophysiology, 6th Edition
b b b b b b
Chapter 01: Cellular Biology
b b b
4. Whichbofbthebfollowingbcanbremovebproteinsbattachedbtobthebcell’sbbilayerbbybdissolvingbthebl
ayerbitself?
a. Peripheralbmembranebproteins
b. Integralbmembranebproteins
c. Glycoproteins
d. Cellbadhesionbmolecules
ANS:b B
Proteinsbdirectlybattachedbtobthebmembranebbilayerbcanbbebremovedbbybthebactionbofbintegralbme
mbranebproteinsbthatbdissolvebthebbilayer.bPeripheralbmembranebproteinsbresidebatbthebsurfacebw
hilebcellbadhesionbmoleculesbarebonbtheboutsidebofbthebmembrane.bGlycoproteinbmarksbcellsband
bdoesbnotbfloat.
REF:b p.b7
5. Whichbofbthebfollowingbcanbbindbtobplasmabmembranebreceptors?
a. Oxygen
b. Ribosomes
c. Amphipathicblipids
d. Ligands
ANS:b D
Ligandsbarebthebonlybspecificbmoleculesbthatbcanbbindbwithbreceptorsbonbthebcellbmembrane.
REF:b p.b9
6. Abnursebisbreviewingbabreportbfrombabpatientbwithbmetastaticbcancer.bWhatbalternationbinbthebe
xtracellularbmatrixbwouldbs uNp p oR hIbeTbdG
Ur btSbtbN iagnBo.
siC
sbofM
metastaticbcancer?
a. Decreasedbfibronectin
b. Increasedbcollagen
c. Decreasedbelastin
d. Increasedbglycoproteins
ANS:b A
Onlybabreducedbamountbofbfibronectinbisbfoundbinbsomebtypesbofbcancerousbcells,ballowingbthemb
tobtravelborbmetastasize.
REF:b p.b10
7. Whichbformbofbcellbcommunicationbisbusedbtobrelatebtobotherbcellsbinbdirectbphysicalbcontact?
a. Cellbjunction
b. Gapbjunction
c. Desmosome
d. Tightbjunction
ANS:b A
Cellbjunctionsbholdbcellsbtogetherbandbpermitbmoleculesbtobpassbfrombcellbtobcell.
Gapbjunctionsballowbforbcellularbcommunicationbbetweenbcells.bNeitherbdesmosomesbnorbtightbjuncti
onsbarebassociatedbwithbcellularbcommunication.
REF:b p.b11
,TESTbBANKbFORbUNDERSTANDINGbPATHOPHYSIOLOGY
Huether & McCance: Understanding Pathophysiology, 6th Edition
b b b b b b
Chapter 01: Cellular Biology
b b b
8. Pancreaticbbetabcellsbsecretebinsulin,bwhichbinhibitsbsecretionbofbglucagonbfrombneighboringb
alphabcells.bThisbactionbisbanbexamplebofbwhichbofbthebfollowingbsignalingbtypes?
a. Paracrine
b. Autocrine
c. Neurohormonal
d. Hormonal
ANS:b A
Paracrinebsignalingbinvolvesbthebreleasebofblocalbchemicalbmediatorsbthatbarebquicklybtakenbup,bd
estroyed,borbimmobilized,basbinbthebcasebofbinsulinbandbthebinhibitionbofbthebsecretionbofbglucago
n.bNonebofbthebotherboptionsbinvolvebsignalingbthatbisbassociatedbwithbablocalbchemicalbmediatorb
likebinsulin.
REF:b p.b12
9. Inbcellularbmetabolism,beachbenzymebhasbabhighbaffinitybforba:
a. solute.
b. substrate.
c. receptor.
d. ribosome.
ANS:b B
Eachbenzymebhasbabhighbaffinitybforbabsubstrate,babspecificbsubstancebconvertedbtobabproductbofbt
hebreaction.bCellularbmetabolismbisbnotbdependentbonbanbattractionbbetweenbanbenzymebandbany
bofbthebremainingboptions.
REF:b b p.b16
10. Anbathletebrunsbabmarathon,bafterbwhichbhisbmusclesbfeelbfatiguedbandbunablebtobcontract.bThebat
hletebasksbthebnursebwhybthisbhappened.bThebnurse’sbresponsebisbbasedbonbthebknowledgebthatbthe
bproblembisbresult bofbabdeficiencybof:
a. GTP
b. AMP
c. ATP
d. GMP
ANS:b C
WhenbATPbisbdeficient,bimpairedbmusclebcontractionbresults.bNonebofbthebotherboptionsbarebinvo
lvedbinbmusclebcontraction.
REF:b p.b16
11. WhichbphasebofbcatabolismbproducesbthebmostbATP?
a. Digestion
b. Glycolysis
c. Oxidation
d. Citricbacidbcycle
ANS:b D
WhilebsomebATPbisbproducedbduringbtheboxidationbandbglycolysisbphases,bmostbofbthebATPbis
, TESTbBANKbFORbUNDERSTANDINGbPATHOPHYSIOLOGY
Huether & McCance: Understanding Pathophysiology, 6th Edition
b b b b b b b
Chapter 01: Cellular Biology
b b b
generatedbduringbthebcitricbacidbcycle.bDigestionbdoesbnotbproducebanybATP.
