with Verified Answers | 100% Correct | i,- i,- i,- i,- i,- i,- i,-
Latest 2025/2026. i,-
What is Zollinger-Ellison syndrome?
i,- i,- rare condition i,- i,-i,- i,- i,- i,-
characterized by gastrin-producing tumors in the duodenum i,- i,- i,- i,- i,- i,- i,-
and/or pancreas that lead to oversecretion of gastrin, which lead
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to gastric and duodenal ulcers that result in gastric bleeding.
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treatment is same as PUD +/- tumor resection i,- i,- i,- i,- i,- i,- i,-
PUD s/s i,- i,-i,- i,- gnawing epigastric pain i,- i,-
relief of pain with eating (duodenal)
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if pain worsens with eating then (epigastric)
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duodenal ulcer i,- i,-i,- i,- age 30-55 i,-
pain relief with EATING
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Peptic Ulcer disease causes and incidence
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men 3:1 i,-
smokers
NSAIDs, ASA, glucocorticoids i,- i,-
,alcohol and dietary factors don't seem to contribute
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zollinger ellison syndrome which is a gastric secreting tumor
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gastric ulcer i,- i,-i,- i,- ages 55-65 i,-
pain worse with EATING
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physical findings of PUD i,- i,- i,- i,-i,- i,- often unremarkable but might have
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epigastric tenderness i,-
GI bleeding 20% of causes- melena, hematemesis or coffee
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ground emesis i,-
perforation s/s i,- i,-i,- i,- board like abdomen i,- i,-
quiet bowel sounds
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RIGIDITY - peritonitis - hole in lumina of GI tract- requires
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immediate surgery (washout with abx) i,- i,- i,- i,-
other acute abdomen causes
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ruptured diverticulum i,-
ruptured appendix i,-
,labs/diagnostics for ulcer i,- i,- i,-i,- i,- can show anemia
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endoscopy after 8-12 weeks of treatment i,- i,- i,- i,- i,-
h. pylori testing
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PPI vs H2RA
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Medical management - H2 receptor antagonist - start with
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dyspepsia
"tidine" i,-i,- i,- cimetidine (tagamet) - 800mg/HS i,- i,- i,-
Famotidine (pepcid) - 40mg/HS i,- i,- i,-
nizatidine (axid) - 300mg/HS i,- i,- i,-
start at HS, then BID, then add PPI
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medical management - PPI - start if pepcid ulcer disease
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suspected
"prazole" i,-i,- i,- lansoprazole (pravacid) - 15mg/day i,- i,- i,-
pantoprazole (protonix) - 20mg/day i,- i,- i,-
omeprazole (prilosec) - 40mg/day i,- i,- i,-
esomeprazole (nexium) - 20mg/day i,- i,- i,-
, rebound GERD i,-
BLACK BOX WARNING - hip fracture with long-term use
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mucosal protective agents i,- i,- i,-i,- i,- sucralfate (carafate) 1 gm QID i,- i,- i,- i,-
i,- - decreases nosocomial PNA
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i,- - avoid antacids and H2 blockers
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bismuth subsalicylate (pepto-bismol) i,- i,-
i,- - helps against h. pylori
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i,- - prostaglandin production/gastric bicarb
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antacids
H. pylori eradication therapy
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2 antibiotics + PPI with or without bismuth for 10 - 14 days
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the abx in H.Pylori tx
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what to ask for eradication therapy?
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macrolide antibiotic use i,- i,-