NURS 660 PSYCHOPHARM (Exam 1-With 100%
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Terms in this set (37)
Typical antipsychotics What class of antipsychotic are these
Neuroleptics, Conventional, First Generation,
Dopamine Receptor Antagonists?
Atypical Antipsychotics What class of antipsychotic are these Second
Generation, Serotonin-Dopamine Receptor
Antagonists
This receptor has the benefit of reducing positive
Dopamine D2 receptor symptoms.
Possible side effects include: Parkinsonism,
akathisia, tardive dyskinesia, endocrine effects
such as prolactin secretion, menstrual
changes and sexual dysfunction.
Serotonin 5-H2a receptor This receptor has the benefit
of reducing EPS Possible side
effects: Sexual dysfunction
Serotonin 5HT2c The benefit of this
receptor receptor is unknown
Side effect is weight
gain
Histamine H-1 receptor The benefit of this receptor is sedation
Side effects are sedation, increased appetite, weight
gain and hypotension
The benefit of the receptor is that it reduces EPS
Muscarinic cholinergic Side effects are autonomic changes such as
receptors blurry vision, dry mouth, constipation, urinary
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, 2/22/25, 3:04 PM NURS 660 PSYCHOPHARM (Exam 1-With 100%
retention, tachycardia and memory dysfunction.
a1-adrenergic receptors Benefit of receptor unknown
Side effects are orthostatic hypertension, dizziness
and reflex tachycardia.
a2-adrenergic receptors Benefit of
receptor unknown
Side effects are
drug interactions
D2-Agonist actions? What makes an antipsychotic conventional?
D2 antagonist/First These antipsychotics share the primary
generation pharmacological property of D2
antipsychotics/Conven antagonism, which is responsible not only for
tional their antipsychotic efficacy, but also for many
antipsychotics/Typical of their side effects.
antipsychotics
These drugs have pharmacological properties
Conventional in addition to D2 antagonism, they block
Antipsychotic
muscarinic cholinergic receptors, histamine h-
1 receptors and/or a1- adrenergic
receptors.
60-80% Antipsychotic properties happen when how much of
the D2 receptor is blocked?
80% The degree of binding in the mesolimbic
pathway needed for antipsychotic effects is?
extrapyramidal side When greater that 80% of D2 receptors are
effects occupied in the dorsal striatum what
happens?
Pituitary gland Which organ is associated with hyperprolactinemia?
Aliphatic These group of Phenothiazine medications are
Phenothiazines low/medium potency agents, with high
(Chlorpromazine, sedation, medium anti-muscarinic effects, and
Levomepromazine, medium extrapyramidal side effects.
Promazine and
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