IMED1004 Study Material with 100%
Correct Solutions
6 bacterial features that contribute to virulence
endospores, capsule, pilli, flagella, plasma membrane, cell wall.
4 adherence mechanisms
glycocalyx, timbre, envelop glycoproteins and ventral adhesive disc
3 things likelihood of disease is dependent on
microbial load, virulence and status of host immune defences
cholera A subunit
gives specificity
cholera B subunit
alters G protein
8 requirements for infection
reservoir, transmission, entry, adherence, multiplication, evasion of host
defences, interference with host function and exit
zoonosis
animal reservoir
PAMPs (pathogen-associated molecular patterns)
shared structures to unique subsets of microbes
TLRs (toll-like receptors)
, on the phagocyte, they recognise PAMPs and stimulate the release of cytokines
Leukocytes (White Blood Cells)
release chemokine and cytokines
chemokine
recruits WBCs
cytokines
Activates WBCs and inflammation
interleukin-1
induces fever
interferons
interfere with viral replication and spread by inducing antiviral states that
inhibit replication
APCs (antigen presenting cells)
activate the adaptive immune system
red pulp of spleen
destruction of RBCs
white pulp of spleen
contains lymphocytes that can stimulate an adaptive immune response.
how do APCs work 3 steps
Correct Solutions
6 bacterial features that contribute to virulence
endospores, capsule, pilli, flagella, plasma membrane, cell wall.
4 adherence mechanisms
glycocalyx, timbre, envelop glycoproteins and ventral adhesive disc
3 things likelihood of disease is dependent on
microbial load, virulence and status of host immune defences
cholera A subunit
gives specificity
cholera B subunit
alters G protein
8 requirements for infection
reservoir, transmission, entry, adherence, multiplication, evasion of host
defences, interference with host function and exit
zoonosis
animal reservoir
PAMPs (pathogen-associated molecular patterns)
shared structures to unique subsets of microbes
TLRs (toll-like receptors)
, on the phagocyte, they recognise PAMPs and stimulate the release of cytokines
Leukocytes (White Blood Cells)
release chemokine and cytokines
chemokine
recruits WBCs
cytokines
Activates WBCs and inflammation
interleukin-1
induces fever
interferons
interfere with viral replication and spread by inducing antiviral states that
inhibit replication
APCs (antigen presenting cells)
activate the adaptive immune system
red pulp of spleen
destruction of RBCs
white pulp of spleen
contains lymphocytes that can stimulate an adaptive immune response.
how do APCs work 3 steps
