ADV. PHARM NURS 8024 WEEK 1
QUESTIONS AND CORRECT
ANSWERS
Legend drugs ✅✅correct answ-another name for prescription drugs
Pharmacogenomics ✅✅correct answ-the study of genetically determined variations in the
response to drugs
Pharmacologic Agonist ✅✅correct answ-agent binds to and activates the
receptor - directly or indirectly causing an effect, full or partial agonists
Pharmacological Antagonist ✅✅correct answ-Agent binds to receptor-completes with other
molecules and prevents binding by other molecules-it inhibits other molecules from binding
Pharmacokinetics ✅✅correct answ-what the body does to the drug
Pharmacodynamics ✅✅correct answ-what the drug does to the body
Toxicology ✅✅correct answ-The undesirable effects of chemicals on living systems
Pharmacotherapeutics ✅✅correct answ-dynamic that achieves the desired therapeutic effect of
the drug without causing other undesirable effects
Pro-drug ✅✅correct answ-An inactive percursor chemical-must be abosorbed and distributed and
converted to the active form of the drug by biologic processes.
What is ADME? ✅✅correct answ-Absorption
Distribution
Metabolism
Elimination
, Absorption ✅✅correct answ-entry of pharmacologic agent into plasma
Distribution ✅✅correct answ-agent leaves the bloodstream and distributes to interstitial and
intracellular fluids
Metablosim ✅✅correct answ-chemical processes that occur to make the drug useful in the
bloodstream--done by the liver, kidney, or other tissue
Ellimination ✅✅correct answ-Leaving the body-via urine, bile, feces, lungs, sweat, breast milk
2 Major Administration Routes ✅✅correct answ-1. Enteral -most common, easy, cheap-BUT drug
absorption pathways can be complicated
2. Parenteral-IV, fast, more expensive, once in-cannot get back
Enteral drug administration ✅✅correct answ-oral, sublingual, rectal
drug absorption pathways complicated
**First-pass metabolism can limit the amount of drug that enters systemic circulation
influenced by food and other drugs
What is first pass metabolism? ✅✅correct answ-The concentration of drug is greatly reduced
BEFORE reaching systemic circulation. This mainly involves liver enzymes, but also includes gastric
enzymes, gut wall enzymes, and bacterial enzymes. Bioavaliability is reduced.
https://www.youtube.com/watch?v=BQQns7RAUzA
Parenteral drug administration ✅✅correct answ--IV, IM, SubQ
- More control over actual dose of drug
- Directly into systemic circulation-bypass first pass metabolism
- used for drugs poorly absorbed by GI
-Rapid onset of action
-Disadvantage: cannot take the drug back, infection risk
QUESTIONS AND CORRECT
ANSWERS
Legend drugs ✅✅correct answ-another name for prescription drugs
Pharmacogenomics ✅✅correct answ-the study of genetically determined variations in the
response to drugs
Pharmacologic Agonist ✅✅correct answ-agent binds to and activates the
receptor - directly or indirectly causing an effect, full or partial agonists
Pharmacological Antagonist ✅✅correct answ-Agent binds to receptor-completes with other
molecules and prevents binding by other molecules-it inhibits other molecules from binding
Pharmacokinetics ✅✅correct answ-what the body does to the drug
Pharmacodynamics ✅✅correct answ-what the drug does to the body
Toxicology ✅✅correct answ-The undesirable effects of chemicals on living systems
Pharmacotherapeutics ✅✅correct answ-dynamic that achieves the desired therapeutic effect of
the drug without causing other undesirable effects
Pro-drug ✅✅correct answ-An inactive percursor chemical-must be abosorbed and distributed and
converted to the active form of the drug by biologic processes.
What is ADME? ✅✅correct answ-Absorption
Distribution
Metabolism
Elimination
, Absorption ✅✅correct answ-entry of pharmacologic agent into plasma
Distribution ✅✅correct answ-agent leaves the bloodstream and distributes to interstitial and
intracellular fluids
Metablosim ✅✅correct answ-chemical processes that occur to make the drug useful in the
bloodstream--done by the liver, kidney, or other tissue
Ellimination ✅✅correct answ-Leaving the body-via urine, bile, feces, lungs, sweat, breast milk
2 Major Administration Routes ✅✅correct answ-1. Enteral -most common, easy, cheap-BUT drug
absorption pathways can be complicated
2. Parenteral-IV, fast, more expensive, once in-cannot get back
Enteral drug administration ✅✅correct answ-oral, sublingual, rectal
drug absorption pathways complicated
**First-pass metabolism can limit the amount of drug that enters systemic circulation
influenced by food and other drugs
What is first pass metabolism? ✅✅correct answ-The concentration of drug is greatly reduced
BEFORE reaching systemic circulation. This mainly involves liver enzymes, but also includes gastric
enzymes, gut wall enzymes, and bacterial enzymes. Bioavaliability is reduced.
https://www.youtube.com/watch?v=BQQns7RAUzA
Parenteral drug administration ✅✅correct answ--IV, IM, SubQ
- More control over actual dose of drug
- Directly into systemic circulation-bypass first pass metabolism
- used for drugs poorly absorbed by GI
-Rapid onset of action
-Disadvantage: cannot take the drug back, infection risk
