ONS/ONCC Chemotherapy
Immunotherapy Certification QUESTIONS
AND ANSWERS
1. Adaptive immunity leads to what? - ANS -immune system memory related to a pathogen
or foreign substance
2. Agranuloyctes are - ANS -T lymphocytes, B lymphocytes, monocytes
3. Granulocytes are - ANS -basophils, eosinophils, neutrophils
4. How are alkylating agents and platinum based chemo's different? - ANS -platinum based
chemo's do not have the molecule to to attach to and destroy DNA
5. How do alkylating agents function? - ANS -by causing a break in the DNA helix strand,
causing interference with DNA replication, which results in cell death
6. How to calculate an ANC - ANS -(%polys or segs + %bands) x WBC/100
7. If a mistake in copies of DNA occur next to a porto-oncogene, it can "turn on" and
become what? - ANS -oncogene
8. If innate immunity proves to be insufficient, what is mobilized? - ANS -adaptive immunity
9. Patient's with what diagnosis are more at risk for anaphylaxis to bleomycin? - ANS
-lymphoma
10.The stem cell divides, producing undifferentiated stem cells that are of what lineage? -
ANS -myeloid or lymphoid
11.What are classes of antitumor antibiotics? - ANS -anthracyclines and non-anthracyclines
12.What are common plant alkaloids? - ANS -etoposide, docetaxol, paclitaxel, vinblastine,
vinorelbine
13.What are cytokines? - ANS -cytokines are secreted by lymphocytes with the intention of
stimulating macrophages and cytotoxic t lymphocytes to identify and kill pathogen
infected cells or tumor cells
14.What are examples of anthracyclines that? - ANS -doxorubicin, daunarubicin, epirubicin,
idarubicin
15.What are examples of non-anthracyclines? - ANS -actinomycin d, mitomycin c,
bleomycin
16.What are lifetime doses needed for anthrcyclines? - ANS -cardiotoxicity
17.What are proto-oncogenes? - ANS -they are a large family of genes that code for
proteins and enzymes that turn on the cell cycle
18.What are regulatory t-cells also known as? - ANS -supressor t-cells
19.What are the most common side effects of antimetabolites? - ANS -myelosuppresion, GI
toxicities, photosensitivity, hand foot syndrome,
20.What are the three most common alkylating agent chemo's? - ANS -cytoxan, ifos,
bendamustine
Immunotherapy Certification QUESTIONS
AND ANSWERS
1. Adaptive immunity leads to what? - ANS -immune system memory related to a pathogen
or foreign substance
2. Agranuloyctes are - ANS -T lymphocytes, B lymphocytes, monocytes
3. Granulocytes are - ANS -basophils, eosinophils, neutrophils
4. How are alkylating agents and platinum based chemo's different? - ANS -platinum based
chemo's do not have the molecule to to attach to and destroy DNA
5. How do alkylating agents function? - ANS -by causing a break in the DNA helix strand,
causing interference with DNA replication, which results in cell death
6. How to calculate an ANC - ANS -(%polys or segs + %bands) x WBC/100
7. If a mistake in copies of DNA occur next to a porto-oncogene, it can "turn on" and
become what? - ANS -oncogene
8. If innate immunity proves to be insufficient, what is mobilized? - ANS -adaptive immunity
9. Patient's with what diagnosis are more at risk for anaphylaxis to bleomycin? - ANS
-lymphoma
10.The stem cell divides, producing undifferentiated stem cells that are of what lineage? -
ANS -myeloid or lymphoid
11.What are classes of antitumor antibiotics? - ANS -anthracyclines and non-anthracyclines
12.What are common plant alkaloids? - ANS -etoposide, docetaxol, paclitaxel, vinblastine,
vinorelbine
13.What are cytokines? - ANS -cytokines are secreted by lymphocytes with the intention of
stimulating macrophages and cytotoxic t lymphocytes to identify and kill pathogen
infected cells or tumor cells
14.What are examples of anthracyclines that? - ANS -doxorubicin, daunarubicin, epirubicin,
idarubicin
15.What are examples of non-anthracyclines? - ANS -actinomycin d, mitomycin c,
bleomycin
16.What are lifetime doses needed for anthrcyclines? - ANS -cardiotoxicity
17.What are proto-oncogenes? - ANS -they are a large family of genes that code for
proteins and enzymes that turn on the cell cycle
18.What are regulatory t-cells also known as? - ANS -supressor t-cells
19.What are the most common side effects of antimetabolites? - ANS -myelosuppresion, GI
toxicities, photosensitivity, hand foot syndrome,
20.What are the three most common alkylating agent chemo's? - ANS -cytoxan, ifos,
bendamustine
