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, Attenuation Correction PET/CT
In PETICT , X - rays from a CT Scan are used to Construct an attenuation Map of
throughout the body that can be used to Correct for the absorption of the photons
decay . The Correction process essentially adds Counts back , " Into areas that are m
to Counts " from areas that are attenuated much less than all Other tissues ( Lung ,
Attenuation Correction : PET/CT
as the loss of detection of true . Coincidence events because of their absorption in
their Scattering out the of the cletector's FOV . Attenuation problems are greater
Compared to traditional Nuc med range 50t8 95.1⁰ especially great In a larger pers
due to attenuation Increases Image noise , artifacts & clistertion
Hanning filter
Cult off frequency at which the filter reacher O. Frequencies above the cutoff are
lower the Cutoff , Smoother the Image .
Butterworth ( low pass )
Two Variables : ( 1 ) Critical frequency ( or Cutoff frequency ) The frequency at
Magnitude drops below a given value . If Set too high ( unfiltered ) , Image will be g
Set too low ( over filtered ) lesinages will be overly Smooth ( Can hide leason).( 2 ) P
: How fast the filter is Cut off or how quickly the transition is made between Frequ
and those are eliminated.
Ramp filter ( high - Filter pass
Used to Suppress the star artifacts and enhance . edges only used in filter ba
Reconstruction
Filter parameters
filters mathematical algorithms , are .. used to decrease Statistical noise in an Image
by removing or reducing the frequencies that make up an Image . SPECT Studies :
help . eliminate the Star artifact produced by back projection and decrease e
Reconstruction :
Registration ( image fusion ) : Is aligning one . or more Images . Moving to mother I
Is Combining Information From 2 or mone Images to Create a more Informative
Consider Image registration as preprocessing Step for Image fusio
Quantitative analysis :
Election fraction Measurement of blood ejected from the Ventricle during each .
activity Curve ( TAC ) : Total number of Counts in ROI placed on a organ at Various
Study plotted as function of time provides info on the organ's physiological funct
uptake values SUV : used as a relative measure of FDG uptake .. It is now Common p
PET / CT oncology roles Patient Cancer Therapy diagnosis
Quantitative analysis .CT
1. Region of Interest : A closed boundary Surrounding an area for which Statistics
methods :
2 Manual method : In which the operator Visually Identifies edge of
, more noise & Vice a versa . Uniformity : Is the Consistency of the CT numbers of a
homogeneous material across the scan field.
CT acquisition (D)
D. Slice thickness : Defined as the Full Width at & maximum ( FWHM ) of Sensiti
Centre of the Scan field . It Value Can be Selected by the Tech according to Clinica
generally lies between 1mm - 10mm.
Back- Projection
A Computer manipulation . of acquired Image data . Into Space proj
Becquerel ( Bq )
The Systeme Internationale Unit of activity , equal to one disintegration per Seco
Beta Cells
Pancreatic Cells in the Islets of Langerhans .
Beta clecay
Radioactive decay of radionuclides resulting in the emission of beta pa
Beta ( B ) Particle
Electron Whole point of crigin is the nucleus electron Originating in the of clecay
neutron Into a proton & electron ( beta Particle )
BGO
Bismuth germinate ; a PET Scanner cletection material .
Bremsstrahlung X - rays
The German word for braking radiation . The mechanism that produes X - rays
Spectrum as the result of rapid deceleration of electrons that pass near the atom
photonic emissions Caused by the Slowing down of bete Particles in m
( COR ) Center of Rotation .
Reference data used for Correcting the Slight Misalignment OF SPECT Images ta
projections
GSO
Gadolinium Orthosilicate A PET Scanner detection Material
Flood Field Unifomity
The ability of a Scintillation Camera to depict a uniform of activity as u
HIPAA Health Insurance Protability & Account ability Act
A u.s. law clesigned to Provide privacy Standards to Protect patients Medical recor
Information . Provided to health Plans cloctors hospitals & Other health Ca
Thyroid
Isotope Pharmaceutcal Intake mechanism of uptake 1. 99m Tc40 IV ) Active transp
Active transport 3 .131 I Ναι ( PO ) Active transport Physiology 3. Acinar Cells Excre
. Gu Pathology 93 Banign ( Hot Spot ) Dose : T. 10-20mci 2. 200-400 uci 3
Pulmonary Perfusion Ventilation .
Isotope Pharmaceutical Intake mechanism of 11. 99 Mtc MAA IV اكuptake " 1. Cap
POXInhale ) 2 Simple cliffusion 3. 99MTC DTPA ( PO ) ( Inhale ) -3 . Simple dif
Pathology 1. Caplipary bed COPD cold 2 Alveolarsacs 3 Alveolar S
, Reference ( air / blank ) Scan ( Daily )
Performed to provide accurate transmission data for attenuation Correction of Ima
of Scanner performance using the rod Sources . or a Ge 68 Cylind
Normalization Calibation ( Quarterly )
Performed to ensure that Individual detectors display the Same response to a Uni
much . like a high Count Uniformity Correction , take at least (6 hrs) to uses the S
Absolute activity ( well Counter ) Calibration ( Quarterly ) .
Used to Convert pixel Values Into a measure of absolute activity per Voxel . Perfo
Precisely known amount of activity and loading a Water - filled phantom Whose V
phantom TS Imaged reconstructed and processed Into a Set of Correction facto
Conversion of an Image that represents a quanitative meastrement of Stand
PET Image acquisition 2Dvs 3D
In 2D mode , thin Septa of lead or tungsten Separte each Crystal ring & Conincidenc
between cletectors within the same ring lying closely neighboring rings. In 3D m
removed and Coincidences are recorded between clectors lying . In any ring
List mode
The Counts are stored Sequentially as xay . Other parameters may be Stored Such a
the R wave from ECG . An advantage of using this methool is it allows Frames
determined after acquisition . Thus , It avoids having to choose between long - Shor
good temporal resolution.
Respiratory gating
A method of Synchronizing Images With respiratory motion to reduce Smearing
Improve quantitation of FT8 uptake lung lesions A Camera - based gating Sys
management ( RPM ) , is used to Monitor the respiratory Cycle
Time of flight ( TOF )
The Concept means Simply that for each annihilation event , we note the precise ti
Coincident photons is detected & Calcution the difference Since the closer photo
detector 1st , the difference in arrivel times helps pin down the location of annihila
the between the two detectors.
CT Quality Control
A. Tube Warm - up : Daily test begin with an x -ray tube Warm up . The results w
System is acceptable for use or report results / passible Serive nee
CT quality Control
B. CT number ( water Phontom ) : The pixel Values assigned in the CT Image ( Hou
are determined by Calculating the relative difference between the linear attenuation
& Water CT # Water the CT # for air 1000 . Awater filled Cylinder phantom is us
Values , noise level resolution Pattern , Should apper to inform with not Str
CT Image acquisition :
A. KVP Kilovolt PEAK ) Typically range from 80-140 Factors . to determine the app
on the body part , Size of patient & position of arms during acquiring Increasin
penetration of the object being X - rayed increase X - ray energy decreases nois
hårdening artifacts However by doing So , Increases close to reduces attenuation Pa
in tissue