NSG 531 - Exam 4 Advanced Pharmacology Solution Manual Fully Solved Latest Update 2025
Ginseng - Answers taken for:
Nervousness, Agitation, Insomnia, Diarrhea, Headaches, Heart Palpitation
Do not take with MAO inhibitors. Can alter affects with heart medications. Can increase the risk of
bleeding when taken with blood clotting drugs
CI: Neuro, Heart, MAO, bleeding, coag drugs
Ma Huang (Ephedra) - Answers Dangerously elevate blood pressure, stimulate heart rate, and CNS
Associated with stroke, MI, and death
Banned > 10 mg in U.S. with exception of traditional Asian medicine
Metabolife
Used for weight loss, allergies, asthma, bronchitis, fever, headache
arginine - Answers Arginine is used for treatment of heart and blood vessel conditions including
congestive heart failure (CHF), chest pain, high blood pressure, and coronary artery disease.
Don't use if:
excess body acid
high levels of potassium in the blood
sickle cell anemia
heart attack within the last 30 days
renal tubular acidosis
decreased kidney function
Don't use with nitro
pt. education for herbs and nutrients - Answers 1. herbs and nutrients have bioactive properties and
have the same safety issues as drugs
2. always consult a reliable source before adding
, 3. consider when researching what are the credentials of the author of the website, what evidence is
there to support their claims, are there any financial interests to influence the claims of the auther
biological basis of drug/herb/nutrient interactions - Answers absorption (changing pH or motility of the
GI tract)
Distribution (displacing agents that are bound to plasma proteins
Biotransformation (inducing or inhibiting CYP450 enzymes)
receptor binding (competitive and noncompetitive antagonism
Gompertzian Kinetics - Answers Cancer cells lack of normal regulating factors leading to abnormal
growth
You can go from 0 to 10^9 before symptoms
This bounces because you go on and off of chemo
That's why we do multiple rounds - so you initiate the next round of chemo before you get back to
where we started
If you initiate chemo at a lower tumor mass you will get a better response in a shorter amount of time
Mechanisms of drug resistance - Answers reduced intracellular drug concentration through drug
inactivation mechanisms, reduced uptake, drug efflux pumps
change in target due to mutation in drug target
insensitivity to apoptosis due to mutation in p53
chemotherapeutics: antemetabolites - Answers inhibit DNA synthesis enzymes
works in the s phase
Ginseng - Answers taken for:
Nervousness, Agitation, Insomnia, Diarrhea, Headaches, Heart Palpitation
Do not take with MAO inhibitors. Can alter affects with heart medications. Can increase the risk of
bleeding when taken with blood clotting drugs
CI: Neuro, Heart, MAO, bleeding, coag drugs
Ma Huang (Ephedra) - Answers Dangerously elevate blood pressure, stimulate heart rate, and CNS
Associated with stroke, MI, and death
Banned > 10 mg in U.S. with exception of traditional Asian medicine
Metabolife
Used for weight loss, allergies, asthma, bronchitis, fever, headache
arginine - Answers Arginine is used for treatment of heart and blood vessel conditions including
congestive heart failure (CHF), chest pain, high blood pressure, and coronary artery disease.
Don't use if:
excess body acid
high levels of potassium in the blood
sickle cell anemia
heart attack within the last 30 days
renal tubular acidosis
decreased kidney function
Don't use with nitro
pt. education for herbs and nutrients - Answers 1. herbs and nutrients have bioactive properties and
have the same safety issues as drugs
2. always consult a reliable source before adding
, 3. consider when researching what are the credentials of the author of the website, what evidence is
there to support their claims, are there any financial interests to influence the claims of the auther
biological basis of drug/herb/nutrient interactions - Answers absorption (changing pH or motility of the
GI tract)
Distribution (displacing agents that are bound to plasma proteins
Biotransformation (inducing or inhibiting CYP450 enzymes)
receptor binding (competitive and noncompetitive antagonism
Gompertzian Kinetics - Answers Cancer cells lack of normal regulating factors leading to abnormal
growth
You can go from 0 to 10^9 before symptoms
This bounces because you go on and off of chemo
That's why we do multiple rounds - so you initiate the next round of chemo before you get back to
where we started
If you initiate chemo at a lower tumor mass you will get a better response in a shorter amount of time
Mechanisms of drug resistance - Answers reduced intracellular drug concentration through drug
inactivation mechanisms, reduced uptake, drug efflux pumps
change in target due to mutation in drug target
insensitivity to apoptosis due to mutation in p53
chemotherapeutics: antemetabolites - Answers inhibit DNA synthesis enzymes
works in the s phase
