NURS 615 PHARMACOLOGY EXAM 1 LATEST
2025-2026 UPDATE QUESTIONS, ANSWERS, AND
RATIONALES |A+ GRADE GUARANTEE
MARYVILLE UNIVERSITY
When a medication is added to a regimen for a synergistic effect, the
combined effect of the drugs is:
1. The sum of the effects of each drug individually
2. Greater than the sum of the effects of each drug individually
3. Less than the effect of each drug individually
4. Not predictable, as it varies with each individual - Answer-2. Greater
than the sum of the effects of each drug individually
Which of the following statements about bioavailability is true?
1. Bioavailability issues are especially important for drugs with narrow
therapeutic ranges or sustained-release mechanisms.
2. All brands of a drug have the same bioavailability.
3. Drugs that are administered more than once a day have greater
bioavailability than drugs given once daily.
,4. Combining an active drug with an inert substance does not affect
bioavailability. - Answer-1. Bioavailability issues are especially
important for drugs with narrow therapeutic
Which of the following statements about the major distribution barriers
(blood-
brain or fetal-placental) is true?
1. Water soluble and ionized drugs cross these barriers rapidly.
2. The blood-brain barrier slows the entry of many drugs into and from
brain cells.
3. The fetal-placental barrier protects the fetus from drugs taken by the
mother.
4. Lipid-soluble drugs do not pass these barriers and are safe for
pregnant women. - Answer-2. The blood-brain barrier slows the entry of
many drugs into and from brain cells.
Drugs are metabolized mainly by the liver via phase I or phase II
reactions. The purpose of both of these types of reactions is to:
1. Inactivate prodrugs before they can be activated by target tissues
2. Change the drugs so they can cross plasma membranes
3. Change drug molecules to a form that an excretory organ can excrete
4. Make these drugs more ionized and polar to facilitate excretion -
Answer-3. Change drug molecules to a form that an excretory organ can
excrete
,Once they have been metabolized by the liver, the metabolites may be:
1. More active than the parent drug
2. Less active than the parent drug
3. Totally "deactivated" so they are excreted without any effect
4. All of the above - Answer-4. All of the above
All drugs continue to act in the body until they are changed or excreted.
The
ability of the body to excrete drugs via the renal system would be
increased by:
1. Reduced circulation and perfusion of the kidney
2. Chronic renal disease
3 Competition for a transport site by another drug
4. Unbinding a nonvolatile drug from plasma proteins - Answer-4.
Unbinding a nonvolatile drug from plasma proteins
Steady state is:
1. The point on the drug concentration curve when absorption exceeds
excretion
2. When the amount of drug in the body remains constant
, 3. When the amount of drug in the body stays below the minimum toxic
concentration
4. All of the above - Answer-2. When the amount of drug in the body
remains constant
Two different pain medications are given together for pain relief. The
drug—drug interaction is:
1. Synergistic
2. Antagonistic
3. Potentiative
4. Additive - Answer-4. Additive
Actions taken to reduce drug—drug interaction problems include all of
the following EXCEPT:
1. Reducing the dosage of one of the drugs
2. Scheduling their administration at different times
3. Prescribing a third drug to counteract the adverse reaction of the
combination
4. Reducing the dosage of both drugs - Answer-3. Prescribing a third
drug to counteract the adverse reaction of the combination
2025-2026 UPDATE QUESTIONS, ANSWERS, AND
RATIONALES |A+ GRADE GUARANTEE
MARYVILLE UNIVERSITY
When a medication is added to a regimen for a synergistic effect, the
combined effect of the drugs is:
1. The sum of the effects of each drug individually
2. Greater than the sum of the effects of each drug individually
3. Less than the effect of each drug individually
4. Not predictable, as it varies with each individual - Answer-2. Greater
than the sum of the effects of each drug individually
Which of the following statements about bioavailability is true?
1. Bioavailability issues are especially important for drugs with narrow
therapeutic ranges or sustained-release mechanisms.
2. All brands of a drug have the same bioavailability.
3. Drugs that are administered more than once a day have greater
bioavailability than drugs given once daily.
,4. Combining an active drug with an inert substance does not affect
bioavailability. - Answer-1. Bioavailability issues are especially
important for drugs with narrow therapeutic
Which of the following statements about the major distribution barriers
(blood-
brain or fetal-placental) is true?
1. Water soluble and ionized drugs cross these barriers rapidly.
2. The blood-brain barrier slows the entry of many drugs into and from
brain cells.
3. The fetal-placental barrier protects the fetus from drugs taken by the
mother.
4. Lipid-soluble drugs do not pass these barriers and are safe for
pregnant women. - Answer-2. The blood-brain barrier slows the entry of
many drugs into and from brain cells.
Drugs are metabolized mainly by the liver via phase I or phase II
reactions. The purpose of both of these types of reactions is to:
1. Inactivate prodrugs before they can be activated by target tissues
2. Change the drugs so they can cross plasma membranes
3. Change drug molecules to a form that an excretory organ can excrete
4. Make these drugs more ionized and polar to facilitate excretion -
Answer-3. Change drug molecules to a form that an excretory organ can
excrete
,Once they have been metabolized by the liver, the metabolites may be:
1. More active than the parent drug
2. Less active than the parent drug
3. Totally "deactivated" so they are excreted without any effect
4. All of the above - Answer-4. All of the above
All drugs continue to act in the body until they are changed or excreted.
The
ability of the body to excrete drugs via the renal system would be
increased by:
1. Reduced circulation and perfusion of the kidney
2. Chronic renal disease
3 Competition for a transport site by another drug
4. Unbinding a nonvolatile drug from plasma proteins - Answer-4.
Unbinding a nonvolatile drug from plasma proteins
Steady state is:
1. The point on the drug concentration curve when absorption exceeds
excretion
2. When the amount of drug in the body remains constant
, 3. When the amount of drug in the body stays below the minimum toxic
concentration
4. All of the above - Answer-2. When the amount of drug in the body
remains constant
Two different pain medications are given together for pain relief. The
drug—drug interaction is:
1. Synergistic
2. Antagonistic
3. Potentiative
4. Additive - Answer-4. Additive
Actions taken to reduce drug—drug interaction problems include all of
the following EXCEPT:
1. Reducing the dosage of one of the drugs
2. Scheduling their administration at different times
3. Prescribing a third drug to counteract the adverse reaction of the
combination
4. Reducing the dosage of both drugs - Answer-3. Prescribing a third
drug to counteract the adverse reaction of the combination
