MURPHY 301 EXAM INTRODUCTION TO
BIOCHEMISTRY | QUESTIONS AND CORRECT
ANSWERS | GRADED A+ | VERIFIED ANSWERS |
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,1/27/25, 5:39 PM MURPHY 301 EXAM INTRODUCTION TO BIOCHEMISTRY | QUESTIONS AND CORRECT ANSWERS | GRADED A+ | VERIFIE…
The side chain of histidine Statement 1 and 2
has a typical pKa value in
the range of 6.5-7.4.
However, when analyzing
the pKa values in a
particular protein,
scientists determined that
one particular His residue
has an unusually low pKa
value of 4.8. Which of the
following statements
correctly explain this
anomaly?
1) The microenvironment
around a residue can
impact its pKa value.
2) A positively charged
amino acid must be in
close proximity to this
residue.
3) A negatively charged
amino acid must be in
close proximity to this
residue.
4) This residue must be
located on the surface of
the protein.
The side chain of ________ Histidine
has a pKa in the
physiological pH range
and is therefore often
involved in proton transfer
during enzymatic
catalysis.
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,1/27/25, 5:39 PM MURPHY 301 EXAM INTRODUCTION TO BIOCHEMISTRY | QUESTIONS AND CORRECT ANSWERS | GRADED A+ | VERIFIE…
All amino acids have a glycine
chiral α-carbon EXCEPT
________.
Which of the following Only statements 2, 3, and 4 are valid.
statements regarding
Anfinsen's denaturing
experiments with
ribonuclease A are valid?
1) Exposing the denatured
protein to air oxidation
and then dialysis to
remove urea restored the
protein to its original
functionality.
2) Removing urea by
dialysis and then allowing
air oxidation of the
denatured protein
restored the protein to its
original functionality.
3) Denaturing the protein
with both urea and β-
mercaptoethanol yielded
an inactive protein.
4) Protein folding is
determined by its primary
sequence.
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, 1/27/25, 5:39 PM MURPHY 301 EXAM INTRODUCTION TO BIOCHEMISTRY | QUESTIONS AND CORRECT ANSWERS | GRADED A+ | VERIFIE…
Which of the following All statements are correct.
statements about protein
quaternary structure are
correct?
1) It involves a complex of
two or more proteins
interacting with each
other.
2) The subunits of the
structure can be either
identical or different.
3) The interactions
between subunits can give
rise to indefinite growth of
polymeric complexes.
4) Most assemblies of
protein subunits have one
or more defined axis of
rotation.
In general, enzymes are proteins
what kinds of molecules?
proteins
minerals
carbohydrates
lipids
nucleic acids
The basic building blocks amino acids
of proteins are _______
All amino acids are central α-carbon that has an amine group
composed what three a carboxylic acid group
things attached to it? and an R group
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