After Guanylate cyclase is activated what are the second messengers, protein kinases,
and effects that follow?
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Guanylate cyclase
cGMP
PKG
Contractile proteins and ion channels
,If TGFß is a Tumor Suppressor Then (3):
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Elements of the TGFß pathway should be inactivated in cancers
TGFß should up-regulate genes that inhibit cell proliferation (eg. p15, p21)
and down-regulate genes that stimulate cell proliferation (eg. E2F1, c-Myc)
Inhibiting TGFß signaling genetically should induce tumor formation and
stimulating TGFß signaling genetically should inhibit tumor formation
The Ras P13K pathway either leads to ______ or _______
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Apoptosis
Cellular response
What is the Basic PLC/Calcium/DAK/PKC Pathway?
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RTK
PLC
PIP2
IP3 DAG
CA rel -> PKC
,AFE stands for
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Accessory Factor Element
B-Arrestin signalinf causes desesitizationa dn the production of what 5 things?
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MAPKs Tyrosine Kinases AKT PI3 Kinases NFkB
What is the Ras - Raf pathway?
What does it result in?
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Ras
Raf
MEK
ERK (extracellular signal-regulated kinases)
Cellular response
What are 4 examples of GPCR ligands?
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, Hormones, Neurotransmitters, Chemokines, Ions, Amino acids, Peptides,
What is a common example of a Channel-linked (inotropic) receptor?
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nicotinic
ACh receptor
After adenylate cyclase is activated what are the second messengers, protein kinases,
and effects that follow?
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adenylate cyclase
cAMP
PKA
Enzymes&transport pros, and ion channels
What is a common example of a Nuclear rec receptor?
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Estrogen Receptor
3 Protein kinase-linked receptors
and effects that follow?
Give this one a try later!
Guanylate cyclase
cGMP
PKG
Contractile proteins and ion channels
,If TGFß is a Tumor Suppressor Then (3):
Give this one a try later!
Elements of the TGFß pathway should be inactivated in cancers
TGFß should up-regulate genes that inhibit cell proliferation (eg. p15, p21)
and down-regulate genes that stimulate cell proliferation (eg. E2F1, c-Myc)
Inhibiting TGFß signaling genetically should induce tumor formation and
stimulating TGFß signaling genetically should inhibit tumor formation
The Ras P13K pathway either leads to ______ or _______
Give this one a try later!
Apoptosis
Cellular response
What is the Basic PLC/Calcium/DAK/PKC Pathway?
Give this one a try later!
RTK
PLC
PIP2
IP3 DAG
CA rel -> PKC
,AFE stands for
Give this one a try later!
Accessory Factor Element
B-Arrestin signalinf causes desesitizationa dn the production of what 5 things?
Give this one a try later!
MAPKs Tyrosine Kinases AKT PI3 Kinases NFkB
What is the Ras - Raf pathway?
What does it result in?
Give this one a try later!
Ras
Raf
MEK
ERK (extracellular signal-regulated kinases)
Cellular response
What are 4 examples of GPCR ligands?
Give this one a try later!
, Hormones, Neurotransmitters, Chemokines, Ions, Amino acids, Peptides,
What is a common example of a Channel-linked (inotropic) receptor?
Give this one a try later!
nicotinic
ACh receptor
After adenylate cyclase is activated what are the second messengers, protein kinases,
and effects that follow?
Give this one a try later!
adenylate cyclase
cAMP
PKA
Enzymes&transport pros, and ion channels
What is a common example of a Nuclear rec receptor?
Give this one a try later!
Estrogen Receptor
3 Protein kinase-linked receptors
