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GMS6552 Exam Questions And Answers
100% Guaranteed Pass.
Most common Drug Target - Answer✔Receptors
Time frame for Channel-linked Receptors - Answer✔Milliseconds
Class name for Channel-linked Receptors - Answer✔Ionotropic receptors
Example of Channel-linked Receptors - Answer✔Nicotinic/ACh Receptors
Time frame for GPCRs - Answer✔Seconds
Class name for GPCRs - Answer✔Metabotropic Receptors
Example of GPCRs - Answer✔Muscarinic/ACh Receptors
Time frame for Kinase-linked Receptors - Answer✔Minutes
Insulin receptors fall under which type of receptor category? - Answer✔Kinase-linked Receptors
How long does it take for insulin to take effect? - Answer✔Minutes
Time frame of Nuclear receptors - Answer✔Hours to Days
How many transmembrane domains are there on GPCRs? - Answer✔7
The alpha subunit of G protein is what type of enzyme? - Answer✔GTPase (slow)
The G-proteins are [intracellular or extracellular]? - Answer✔intracellular, but membrane
associated
The N-terminus of the GPCR is - Answer✔Extracellular
The C-terminus of the GPCR is - Answer✔Intracellular
When what is bound to alpha subunit, are the g proteins turned on? - Answer✔GTP
alpha S subunit of G protein activates - Answer✔adenylyl cyclase
Adenylyl cyclase increases - Answer✔cAMP
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cAMP activates - Answer✔PKA
alpha I subunit of G proteins inhibits - Answer✔Adenylyl cyclase
alpha q subunit of G protein activates - Answer✔PLC
PLC increases levels of what two things? - Answer✔DAG and IP3
IP3 increases levels of intracellular _________ - Answer✔Calcium
DAG activates - Answer✔PKC
T/F: There are no 2nd messengers in Kinase-linked receptor signaling - Answer✔True
In receptors associated w/ cytosolic kinases:
Receptors are initially _____________________
once ligand binds, they _______________________
After that, ________ gets activated which will phosphorylate __________ residues. -
Answer✔monomeric; dimerize; JAK; Tyrosine
In receptors associated w/ cytosolic kinases, proteins with _______ domains (such as STAT,
SHC, GRB2, PI3K) bind and gets activated via ______________ of those residues. Once
activated, they act as __________________ and translocate to the ______________. -
Answer✔SH2; phosphorylation; Trxn factors; nucleus
Receptor tyrosine kinases have ____________________ tyrosine kinase activity. -
Answer✔Intrinsic
T/F: Insulin acts on receptor tyrosine kinases. - Answer✔True
The _____ subunits of receptor tyrosine kinases phosphorylate _________ residues. -
Answer✔beta; tyrosine
In receptor tyrosine kinases that have insulin bound, phosphorylated tyrosine residues will
phosphorylate ________ which will activate ______________ and the ___________ pathways. -
Answer✔IRS; GRB2/mSOS; PI3K
The GRB2/mSOS pathway activates _____________. - Answer✔mek, MAPK, etc.
The PI3K pathway activates _____________ pathway which phosphorylates effector proteins. -
Answer✔PKB/AKT
In receptor Ser/Thr kinases, ligands bind to type _____ receptor which will then ___________
with the type ___ receptor. - Answer✔2; dimerize; 1
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Once receptor Ser/Thr Kinases are activated, the type ____ receptor will phosphorylate the
type ____ receptor. - Answer✔2; 1
Once the type 1 receptor is phosphorylated on Ser/Thr kinase receptors, it will phosphorylate
which type of proteins? - Answer✔SMADs or Receptor Activated SMADs or R-SMADs
SMADs will then act as _________ which translocate to the nucleus - Answer✔Trxn Factors
T/F: Nitric Oxide can bind on or in the cell. - Answer✔True
NO can bind to ________ ion in proteins or to ____ atoms on proteins resulting in allosteric
changes. - Answer✔Metal; Sulfur
Once NO has bound to its receptor, this will activate soluble ____________________ which
increases levels of ______________, a 2nd messenger. - Answer✔guanylyl cyclase; cGMP
T/F: Notch signaling is a method for which ligands on cell surfaces can act as a method for
signaling. - Answer✔True
In notch signaling, ____________ cleave ICN which will translocate to the nucleus. -
Answer✔metalloproteases
TGF-b + Fibroblasts -> _______________
TGF-b + Epithelial Cells -> _____________ - Answer✔Pro-growth
Inhibited growth
TGF-b is produced as a ____________ form and must be activated. - Answer✔Latent
Latent TGF-b is activated by ________________. - Answer✔Plasmin
Latent TGF-b can be prevented from being activated by plasmin by what? (ie. What inhibits
plasmin's activity?) - Answer✔Lipoprotein A
_________ are the primary mediators of TGF-b signaling - Answer✔SMADs
___-SMADs are the primary SMADs that get phosphorylated by the Type 1 receptor Ser/Thr
kinases. - Answer✔R-SMADs
List the R-SMADs. - Answer✔1, 2, 3, 5, 8, 9
T/F: R-SMADs are not specific for the genes of interest. - Answer✔False
Which type of SMAD binds to activated SMADs? - Answer✔Co-SMADs
What is the only Co-SMAD? - Answer✔4
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GMS6552 Exam Questions And Answers
100% Guaranteed Pass.
Most common Drug Target - Answer✔Receptors
Time frame for Channel-linked Receptors - Answer✔Milliseconds
Class name for Channel-linked Receptors - Answer✔Ionotropic receptors
Example of Channel-linked Receptors - Answer✔Nicotinic/ACh Receptors
Time frame for GPCRs - Answer✔Seconds
Class name for GPCRs - Answer✔Metabotropic Receptors
Example of GPCRs - Answer✔Muscarinic/ACh Receptors
Time frame for Kinase-linked Receptors - Answer✔Minutes
Insulin receptors fall under which type of receptor category? - Answer✔Kinase-linked Receptors
How long does it take for insulin to take effect? - Answer✔Minutes
Time frame of Nuclear receptors - Answer✔Hours to Days
How many transmembrane domains are there on GPCRs? - Answer✔7
The alpha subunit of G protein is what type of enzyme? - Answer✔GTPase (slow)
The G-proteins are [intracellular or extracellular]? - Answer✔intracellular, but membrane
associated
The N-terminus of the GPCR is - Answer✔Extracellular
The C-terminus of the GPCR is - Answer✔Intracellular
When what is bound to alpha subunit, are the g proteins turned on? - Answer✔GTP
alpha S subunit of G protein activates - Answer✔adenylyl cyclase
Adenylyl cyclase increases - Answer✔cAMP
1|Page
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cAMP activates - Answer✔PKA
alpha I subunit of G proteins inhibits - Answer✔Adenylyl cyclase
alpha q subunit of G protein activates - Answer✔PLC
PLC increases levels of what two things? - Answer✔DAG and IP3
IP3 increases levels of intracellular _________ - Answer✔Calcium
DAG activates - Answer✔PKC
T/F: There are no 2nd messengers in Kinase-linked receptor signaling - Answer✔True
In receptors associated w/ cytosolic kinases:
Receptors are initially _____________________
once ligand binds, they _______________________
After that, ________ gets activated which will phosphorylate __________ residues. -
Answer✔monomeric; dimerize; JAK; Tyrosine
In receptors associated w/ cytosolic kinases, proteins with _______ domains (such as STAT,
SHC, GRB2, PI3K) bind and gets activated via ______________ of those residues. Once
activated, they act as __________________ and translocate to the ______________. -
Answer✔SH2; phosphorylation; Trxn factors; nucleus
Receptor tyrosine kinases have ____________________ tyrosine kinase activity. -
Answer✔Intrinsic
T/F: Insulin acts on receptor tyrosine kinases. - Answer✔True
The _____ subunits of receptor tyrosine kinases phosphorylate _________ residues. -
Answer✔beta; tyrosine
In receptor tyrosine kinases that have insulin bound, phosphorylated tyrosine residues will
phosphorylate ________ which will activate ______________ and the ___________ pathways. -
Answer✔IRS; GRB2/mSOS; PI3K
The GRB2/mSOS pathway activates _____________. - Answer✔mek, MAPK, etc.
The PI3K pathway activates _____________ pathway which phosphorylates effector proteins. -
Answer✔PKB/AKT
In receptor Ser/Thr kinases, ligands bind to type _____ receptor which will then ___________
with the type ___ receptor. - Answer✔2; dimerize; 1
2|Page
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Once receptor Ser/Thr Kinases are activated, the type ____ receptor will phosphorylate the
type ____ receptor. - Answer✔2; 1
Once the type 1 receptor is phosphorylated on Ser/Thr kinase receptors, it will phosphorylate
which type of proteins? - Answer✔SMADs or Receptor Activated SMADs or R-SMADs
SMADs will then act as _________ which translocate to the nucleus - Answer✔Trxn Factors
T/F: Nitric Oxide can bind on or in the cell. - Answer✔True
NO can bind to ________ ion in proteins or to ____ atoms on proteins resulting in allosteric
changes. - Answer✔Metal; Sulfur
Once NO has bound to its receptor, this will activate soluble ____________________ which
increases levels of ______________, a 2nd messenger. - Answer✔guanylyl cyclase; cGMP
T/F: Notch signaling is a method for which ligands on cell surfaces can act as a method for
signaling. - Answer✔True
In notch signaling, ____________ cleave ICN which will translocate to the nucleus. -
Answer✔metalloproteases
TGF-b + Fibroblasts -> _______________
TGF-b + Epithelial Cells -> _____________ - Answer✔Pro-growth
Inhibited growth
TGF-b is produced as a ____________ form and must be activated. - Answer✔Latent
Latent TGF-b is activated by ________________. - Answer✔Plasmin
Latent TGF-b can be prevented from being activated by plasmin by what? (ie. What inhibits
plasmin's activity?) - Answer✔Lipoprotein A
_________ are the primary mediators of TGF-b signaling - Answer✔SMADs
___-SMADs are the primary SMADs that get phosphorylated by the Type 1 receptor Ser/Thr
kinases. - Answer✔R-SMADs
List the R-SMADs. - Answer✔1, 2, 3, 5, 8, 9
T/F: R-SMADs are not specific for the genes of interest. - Answer✔False
Which type of SMAD binds to activated SMADs? - Answer✔Co-SMADs
What is the only Co-SMAD? - Answer✔4
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