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GMS6552 Exam Questions And Answers
100% Guaranteed Pass.
Which type of receptor most often utilizes second messenger systems in its signaling?
•kinase linked receptors
•channel linked receptors
•nuclear receptors
•G protein coupled receptors - Answer✔G protein coupled receptors
assume you have receptor antagonists that are able to stop receptor signaling immediately. for
which type of receptor would it take the longest to see the effects of your drug at the cellular
level?
•kinase linked receptors
•channel linked receptors
•nuclear receptors
•G protein coupled receptors - Answer✔nuclear receptors
for which type of receptor would having adequate membrane permeability of an agonist be
most critical?
•kinase linked receptors
•channel linked receptors
•nuclear receptors
•G protein coupled receptors - Answer✔nuclear receptors
1|Page
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is it more likely for a G protein coupled receptor agonist to bind near the N or C terminus of the
receptor?
•N terminus
•C terminus - Answer✔N terminus
is it more likely to find a GCPR bound to a G protein that is also bound to GTP or GDP?
•GTP
•GDP - Answer✔GDP
which protein ultimately is translocated from the cytoplasm to the nucleus as a result of JAK
signaling?
•JAK
•GRB2
•SH2
•PI3K
•STAT - Answer✔STAT
where in relation to the protein ciding region of a gene are the binding sites that become
occupied by nuclear receptors?
•upstream
•within the coding region
•downstream - Answer✔upstream
the levels of which second messenger would be expected to increase following administration
of nitroglycerin?
•Ca2+
•cAMP
2|Page
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•carbon monoxide
•diacylglycerol
•cGMP
•kaboom! - Answer✔cGMP
does TGF-beta treatment cause cells to grow more or less in the soft agar assay?
•more
•less - Answer✔more
the latent TBF-beta peptide must be cleaved by what protease in order to be activated?
•plasmin
•trypsin
•papain
•chymotrypsin
•PARP - Answer✔plasmin
in the TGF-beta pathway, which protein becomes activated first upon binding of a ligand?
•R-Smad
•TGFbetaR1
•Co-Smad
•TGFbetaR2 - Answer✔TGFbetaR2
how many DNA binding domains do Smads have?
•0
•1
•2
•3
3|Page
GMS6552 Exam Questions And Answers
100% Guaranteed Pass.
Which type of receptor most often utilizes second messenger systems in its signaling?
•kinase linked receptors
•channel linked receptors
•nuclear receptors
•G protein coupled receptors - Answer✔G protein coupled receptors
assume you have receptor antagonists that are able to stop receptor signaling immediately. for
which type of receptor would it take the longest to see the effects of your drug at the cellular
level?
•kinase linked receptors
•channel linked receptors
•nuclear receptors
•G protein coupled receptors - Answer✔nuclear receptors
for which type of receptor would having adequate membrane permeability of an agonist be
most critical?
•kinase linked receptors
•channel linked receptors
•nuclear receptors
•G protein coupled receptors - Answer✔nuclear receptors
1|Page
, ©JASONMcCONNELL 2024/2025 ALL RIGHTS RESERVED.
is it more likely for a G protein coupled receptor agonist to bind near the N or C terminus of the
receptor?
•N terminus
•C terminus - Answer✔N terminus
is it more likely to find a GCPR bound to a G protein that is also bound to GTP or GDP?
•GTP
•GDP - Answer✔GDP
which protein ultimately is translocated from the cytoplasm to the nucleus as a result of JAK
signaling?
•JAK
•GRB2
•SH2
•PI3K
•STAT - Answer✔STAT
where in relation to the protein ciding region of a gene are the binding sites that become
occupied by nuclear receptors?
•upstream
•within the coding region
•downstream - Answer✔upstream
the levels of which second messenger would be expected to increase following administration
of nitroglycerin?
•Ca2+
•cAMP
2|Page
, ©JASONMcCONNELL 2024/2025 ALL RIGHTS RESERVED.
•carbon monoxide
•diacylglycerol
•cGMP
•kaboom! - Answer✔cGMP
does TGF-beta treatment cause cells to grow more or less in the soft agar assay?
•more
•less - Answer✔more
the latent TBF-beta peptide must be cleaved by what protease in order to be activated?
•plasmin
•trypsin
•papain
•chymotrypsin
•PARP - Answer✔plasmin
in the TGF-beta pathway, which protein becomes activated first upon binding of a ligand?
•R-Smad
•TGFbetaR1
•Co-Smad
•TGFbetaR2 - Answer✔TGFbetaR2
how many DNA binding domains do Smads have?
•0
•1
•2
•3
3|Page
