Module 3: hyperandrogenic
disorders with 100% correct
answers 2025
disorders with symptoms of hirsutism, acne, alopecia, irregular
menses, and associated w/ cardiometabolic dysfunction and
psychological distress - answer Hyperandrogenic disorders
PCOS - answer Most common cause of hyperandrogenism, occurs in
approximately 80% of women with androgen excess
Clinical and/ or biochemical evidence of hyperandrogenism
Oligo-anovulation
Polycystic ovaries
Exclusion of other etiologies
Nonclassical congenital adrenal hyperplasia - answer Occurs in
approximately 2% of women with androgen excess Clinically
indistinguishable from PCOS Elevated 17-hydroxyprogesterone (17-
OHP), greater than 800 ng/ dL
Hyperandrogenism, insulin resistance, and acanthosis nigrans
(HAIR-AN) syndrome - answer Occurs in approximately 4% of women
with androgen excess
Severe hyperandrogenism, possible virilization
Acanthosis nigricans
Severe hyperinsulinemia/ insulin resistance
Androgen-producing tumors (ovarian or adrenal) - answer Rare
Acute, rapid course of virilizing symptoms
,Testosterone usually elevated to more than 150 ng/ dL in
premenopausal women or more than 100 ng/ dL in postmenopausal
women
Palpable adnexal mass or mass on imaging of ovaries or adrenal
glands
Cushing syndrome - answer Frequent referral diagnosis, one of the
least common final diagnoses
Evidence of striae over abdomen, central weight distribution,
muscle weakness, altered mood, easy bruisability
Failure of cortisol suppression after overnight dexamethasone
suppression test
Thyroid disorders - answer Palpable thyroid enlargement or mass
Suspect with presence of alopecia
Elevated thyroid-stimulating hormone
Androgenic medication use - answer May be systemic or topical
Hirsutism is common
Idiopathic hirsutism - answer Occurs in approximately 5% of women
with androgen excess
Normal serum androgen levels
Normal ovulation by basal body temperature charting or luteal-
phase progesterone measurements
Pregnancy - answer Rapid virilization occurs during pregnancy
Common causes: pregnancy luteoma or theca-lutein cysts
(hyperreactio luteinalis)
Hyperprolactinemia - answer Galactorrhea
levated prolactin level
, Associated diseases with hyperandrogenic disorders - answer
Hypertension
Diabetes mellitus
mood disorders
infertility/ subfertility
most common hyperadndrogenic disorder - answer polycystic ovary
syndrome (PCODS) : reproductive-aged women
clinical hyperandrogenism - answer hirsutism, acne, and androgenic
alopecia
increased androgen production in PCOS occurs in what organs? -
answer Ovaries
Adrenals
PCOS symptoms - answer *cutaneous: acne, hirsutism, alopecia,
acanthosis nigricans
*anovulatory: menstrual irregularity, amenorrhea, oligomenorrhea,
dysfunctional uterine bleeding, and infertility/ subfertility (typically
begins in teenage years)
*hyperinsulinemia
*mood disorders especially in adolescents
Increased risk for adverse health outcomes with PCOS - answer
endometrial cancer
type 2 diabetes
CV diseases
disorders with 100% correct
answers 2025
disorders with symptoms of hirsutism, acne, alopecia, irregular
menses, and associated w/ cardiometabolic dysfunction and
psychological distress - answer Hyperandrogenic disorders
PCOS - answer Most common cause of hyperandrogenism, occurs in
approximately 80% of women with androgen excess
Clinical and/ or biochemical evidence of hyperandrogenism
Oligo-anovulation
Polycystic ovaries
Exclusion of other etiologies
Nonclassical congenital adrenal hyperplasia - answer Occurs in
approximately 2% of women with androgen excess Clinically
indistinguishable from PCOS Elevated 17-hydroxyprogesterone (17-
OHP), greater than 800 ng/ dL
Hyperandrogenism, insulin resistance, and acanthosis nigrans
(HAIR-AN) syndrome - answer Occurs in approximately 4% of women
with androgen excess
Severe hyperandrogenism, possible virilization
Acanthosis nigricans
Severe hyperinsulinemia/ insulin resistance
Androgen-producing tumors (ovarian or adrenal) - answer Rare
Acute, rapid course of virilizing symptoms
,Testosterone usually elevated to more than 150 ng/ dL in
premenopausal women or more than 100 ng/ dL in postmenopausal
women
Palpable adnexal mass or mass on imaging of ovaries or adrenal
glands
Cushing syndrome - answer Frequent referral diagnosis, one of the
least common final diagnoses
Evidence of striae over abdomen, central weight distribution,
muscle weakness, altered mood, easy bruisability
Failure of cortisol suppression after overnight dexamethasone
suppression test
Thyroid disorders - answer Palpable thyroid enlargement or mass
Suspect with presence of alopecia
Elevated thyroid-stimulating hormone
Androgenic medication use - answer May be systemic or topical
Hirsutism is common
Idiopathic hirsutism - answer Occurs in approximately 5% of women
with androgen excess
Normal serum androgen levels
Normal ovulation by basal body temperature charting or luteal-
phase progesterone measurements
Pregnancy - answer Rapid virilization occurs during pregnancy
Common causes: pregnancy luteoma or theca-lutein cysts
(hyperreactio luteinalis)
Hyperprolactinemia - answer Galactorrhea
levated prolactin level
, Associated diseases with hyperandrogenic disorders - answer
Hypertension
Diabetes mellitus
mood disorders
infertility/ subfertility
most common hyperadndrogenic disorder - answer polycystic ovary
syndrome (PCODS) : reproductive-aged women
clinical hyperandrogenism - answer hirsutism, acne, and androgenic
alopecia
increased androgen production in PCOS occurs in what organs? -
answer Ovaries
Adrenals
PCOS symptoms - answer *cutaneous: acne, hirsutism, alopecia,
acanthosis nigricans
*anovulatory: menstrual irregularity, amenorrhea, oligomenorrhea,
dysfunctional uterine bleeding, and infertility/ subfertility (typically
begins in teenage years)
*hyperinsulinemia
*mood disorders especially in adolescents
Increased risk for adverse health outcomes with PCOS - answer
endometrial cancer
type 2 diabetes
CV diseases
