Test Bank For Robbins & Cotran Pathologic Basis of Disease 9th Edition By Vinay Kumar, Abul Abbas, Jon Aster 9781455726134 Chapter 1-29 Complete Guide .2

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Chapterr03:rInflammationrandrRepairrTes

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MULTIPLErCHOICE

1. Transmembraneradhesiverheterodimericrproteins,rcomposedrofranrrandrarßrchain,rarerexpressedr
onractivatedrleukocytesrduringrinflammation.rTheyrbindrprimarilyrtorintercellularradhesionrmole
culer1r(ICAM-1)randrvascularrcellradhesionrmoleculer1r(VCAM-
1),rbothrofrwhichrbelongrtortherfamilyrofrproteinsrknownras
a. selectins
b. integrins
c. immunoglobulins
d. lectins
e. growthrfactors

ANS:rC,rSurfacerproteinsrexpressedronractivatedrleukocytesrarerintegrins,randrtheyrbindrtorinterc
ellularradhesionrmoleculer1r(ICAM-1)randrvascularrcellradhesionrmoleculer1r(VCAM-
r1),rwhichrbelongrtortherimmunoglobulinrfamilyrofrproteins.




2. Whichr ofr ther followingr mediatorsr ofr inflammationr hasr chemotacticr propertiesr andr isrinc
reasedrinrpersonsrtakingraspirin?
a. ThromboxanerA2
b. ProstaglandinrE2
c. Platelet-activatingrfactor
d. LeukotrienerB4
e. Interleukin-1

ANS:rD,rLeukotrienerB4risrchemotactic.rItrisrincreasedrinrpersonsrwhortakeraspirin,rbecauseraspiri
nrinhibitsrthercyclooxygenaserpathway,rthusrshuntingrmorerarachidonicracidrearlyrderivativesrint
ortherlipoxygenaserpathway.rThisrpromotesrthersynthesisrofrleukotrienes.

3. Ar 2-year-
oldr childr knownr tor sufferr fromr recurrentr bacterialr infectionsr andr poorr woundr healingr wasr f
oundr tor haver leukocyter adhesionr moleculer deficiencyr 1r (LAD-1).r The

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, leukocytesrofrthisrpatientrdornotrexpressrCD18,rarmoleculerclassifiedrasrbelongingrtortherfamilyrof
a. selectins
b. integrins
c. lectinrtyperofrvascularradhesionrmolecules
d. aminotransferases
e. glycosidases




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