MICR 386 EXAM Questions and Answers
Cytokines supporting T cell proliferation/activation - Answer-IL-2, IL-4, IL-12
Cytokines supporting B cell proliferation/differentiation - Answer-IL-2, IL-4, IL-5, IL-7
Pro-inflammatory cytokines - Answer-IL-1B, TNF-a, IL-6
Anti-inflammatory cytokines - Answer-IL-10 and TGF-B
what are Th1 cells induced by - Answer-Il-12 and STAT 4. Results in cell-mediated response
What are Th2 cells induced by? - Answer-Il-4 and STAT 6. Results in humoral response
Lymphoid and Myeloid cancer cause - Answer-Overproduction of IL-6, tumour supressing genes no
longer suppressed
Chagas Disease cause - Answer-Caused by parasite. Inability to supress IL-2 receptor expression. Results
in suppressed immune response
, Cytokines that keep memory B cells alive (survival niche) - Answer-Il-5, IL-6, TNF-a
Multiple myeloma - Answer-Cancer of memory plasma B cells. Results from disregulated survival niche.
Cells have dutcher body, mott cell, rusell body
Original antigenic sin - Answer-Antibodies generated are specific to original epitope. Memory cells are
specific to that epitope, and not new mutations. During secondary immune response, it is weaker due to
change in epitope.
HIGM syndrome - Answer-X-linked defect in gene for CD40L gene for helper T cells. Incapable of
inducing class switching from IgM -> G, E, A
Type I TI antigens - Answer-polyclonal B cell activator, PKC pathway induces proliferation +
differentiation
Type 2 TI antigens - Answer-Antigen binds BCR through cross linking, requires cytokines from T cells, InS
pathway induces proliferation +differentiation
Cells involved in non-specific cell mediated immunity - Answer-Macrophages, NK cells
Cells involved in specific cell mediated immunity - Answer-Th1 cells, cytotoxic T cells
Effects of macrophages in CMI - Answer-production of reactive oxygen species, secrete cytokines,
increased T cell activation (increase B7 costimulators)
Effects of NK cells in CMI - Answer-When cell is infected, there is down-regulation of MHC I. If no MHC I
is recognized, the cell is killed
Cytokines supporting T cell proliferation/activation - Answer-IL-2, IL-4, IL-12
Cytokines supporting B cell proliferation/differentiation - Answer-IL-2, IL-4, IL-5, IL-7
Pro-inflammatory cytokines - Answer-IL-1B, TNF-a, IL-6
Anti-inflammatory cytokines - Answer-IL-10 and TGF-B
what are Th1 cells induced by - Answer-Il-12 and STAT 4. Results in cell-mediated response
What are Th2 cells induced by? - Answer-Il-4 and STAT 6. Results in humoral response
Lymphoid and Myeloid cancer cause - Answer-Overproduction of IL-6, tumour supressing genes no
longer suppressed
Chagas Disease cause - Answer-Caused by parasite. Inability to supress IL-2 receptor expression. Results
in suppressed immune response
, Cytokines that keep memory B cells alive (survival niche) - Answer-Il-5, IL-6, TNF-a
Multiple myeloma - Answer-Cancer of memory plasma B cells. Results from disregulated survival niche.
Cells have dutcher body, mott cell, rusell body
Original antigenic sin - Answer-Antibodies generated are specific to original epitope. Memory cells are
specific to that epitope, and not new mutations. During secondary immune response, it is weaker due to
change in epitope.
HIGM syndrome - Answer-X-linked defect in gene for CD40L gene for helper T cells. Incapable of
inducing class switching from IgM -> G, E, A
Type I TI antigens - Answer-polyclonal B cell activator, PKC pathway induces proliferation +
differentiation
Type 2 TI antigens - Answer-Antigen binds BCR through cross linking, requires cytokines from T cells, InS
pathway induces proliferation +differentiation
Cells involved in non-specific cell mediated immunity - Answer-Macrophages, NK cells
Cells involved in specific cell mediated immunity - Answer-Th1 cells, cytotoxic T cells
Effects of macrophages in CMI - Answer-production of reactive oxygen species, secrete cytokines,
increased T cell activation (increase B7 costimulators)
Effects of NK cells in CMI - Answer-When cell is infected, there is down-regulation of MHC I. If no MHC I
is recognized, the cell is killed
