APEA- Psych Pharm Final Exam.
Bupropion (Wellbutrin), used in the treatment of depression, should NOT be administered to a patient
with:
alcoholism.
attention deficit disorder.
hypertension.
seizure disorder. - CORRECT ANSWER seizure disorder.
First-generation antipsychotics (e.g., haloperidol [Haldol]) are associated with side effects including:
sedation.
tardive dyskinesia.
weight gain.
weight loss. - CORRECT ANSWER tardive dyskinesia.
If methylphenidate is contraindicated, which of the following medications is recommended for
treatment of ADHD in an adult?
Bupropion (Wellbutrin)
Clonazepam (Klonopin)
Fluoxetine (Prozac)
Phenelzine (Nardil) - CORRECT ANSWER Bupropion (Wellbutrin)
Therapeutic drug levels and predictability of clinical response are difficult to determine in first-
generation antipsychotics (e.g., haloperidol [Haldol]) because they:
are poorly absorbed in the intestines, hydrophilic and highly protein bound.
, are highly bioavailable and poorly protein bound.
have a decreased first pass effect, are hydrophilic and poorly protein bound.
have variable bioavailability, are lipophilic and highly protein bound. - CORRECT ANSWER have variable
bioavailability, are lipophilic and highly protein bound.
Guanfacine (Intuniv), used in the treatment of attention deficit disorder, is classified as a(n):
alpha-2-adrenergic agonist.
selective norepinephrine reuptake inhibitor.
sympathomimetic/stimulant.
tricyclic antidepressant. - CORRECT ANSWER alpha-2-adrenergic agonist.
Suvorexant (Belsomra), used in the treatment of insomnia, induces sleep by:
activating melatonin receptors.
blocking the signals of orexin chemicals in the hypothalamus.
increasing the catabolism of tryptophan.
raising the levels of gamma-aminobutyric acid (GABA). - CORRECT ANSWER blocking the signals of orexin
chemicals in the hypothalamus.
The mechanism of action of second-generation antipsychotic medications such as aripiprazole (Abilify)
does NOT include:
5-HT2A receptor blockade.
dopamine D2 receptor blockade.
serotonin reuptake stimulation.
enhanced dopamine release. - CORRECT ANSWER serotonin reuptake stimulation.
After initiation or increase in dose of a selective serotonin receptor inhibitor (SSRI) such as escitalopram
(Lexapro), the patient should be monitored for:
Bupropion (Wellbutrin), used in the treatment of depression, should NOT be administered to a patient
with:
alcoholism.
attention deficit disorder.
hypertension.
seizure disorder. - CORRECT ANSWER seizure disorder.
First-generation antipsychotics (e.g., haloperidol [Haldol]) are associated with side effects including:
sedation.
tardive dyskinesia.
weight gain.
weight loss. - CORRECT ANSWER tardive dyskinesia.
If methylphenidate is contraindicated, which of the following medications is recommended for
treatment of ADHD in an adult?
Bupropion (Wellbutrin)
Clonazepam (Klonopin)
Fluoxetine (Prozac)
Phenelzine (Nardil) - CORRECT ANSWER Bupropion (Wellbutrin)
Therapeutic drug levels and predictability of clinical response are difficult to determine in first-
generation antipsychotics (e.g., haloperidol [Haldol]) because they:
are poorly absorbed in the intestines, hydrophilic and highly protein bound.
, are highly bioavailable and poorly protein bound.
have a decreased first pass effect, are hydrophilic and poorly protein bound.
have variable bioavailability, are lipophilic and highly protein bound. - CORRECT ANSWER have variable
bioavailability, are lipophilic and highly protein bound.
Guanfacine (Intuniv), used in the treatment of attention deficit disorder, is classified as a(n):
alpha-2-adrenergic agonist.
selective norepinephrine reuptake inhibitor.
sympathomimetic/stimulant.
tricyclic antidepressant. - CORRECT ANSWER alpha-2-adrenergic agonist.
Suvorexant (Belsomra), used in the treatment of insomnia, induces sleep by:
activating melatonin receptors.
blocking the signals of orexin chemicals in the hypothalamus.
increasing the catabolism of tryptophan.
raising the levels of gamma-aminobutyric acid (GABA). - CORRECT ANSWER blocking the signals of orexin
chemicals in the hypothalamus.
The mechanism of action of second-generation antipsychotic medications such as aripiprazole (Abilify)
does NOT include:
5-HT2A receptor blockade.
dopamine D2 receptor blockade.
serotonin reuptake stimulation.
enhanced dopamine release. - CORRECT ANSWER serotonin reuptake stimulation.
After initiation or increase in dose of a selective serotonin receptor inhibitor (SSRI) such as escitalopram
(Lexapro), the patient should be monitored for:
