GMS6552 EXAM 1 QUESTIONS WITH
VERIFIED CORRECT ANSWERS
4 receptor types in order of their speed - CORRECT ANSWER-1. Channel-linked
(inotropic) - millisecs
2. G-prot coupled rec - seconds
3. Kinase linked - minutes
4. Nuclear rec - hours
What is a common example of a Channel-linked (inotropic) receptor? - CORRECT
ANSWER-nicotinic
ACh receptor
What is a common example of a G-prot coupled receptor? - CORRECT ANSWER-
Muscarinic ACh Receptor
What is a common example of a Kinase linked receptor? - CORRECT ANSWER-
Insulin Receptor
What is a common example of a Nuclear rec receptor? - CORRECT ANSWER-
Estrogen Receptor
What are 4 examples of GPCR ligands? - CORRECT ANSWER-Hormones,
Neurotransmitters, Chemokines, Ions, Amino acids, Peptides,
What are the 3 main Ga proteins? - CORRECT ANSWER-Gas- AC - inc
GMS6552 Exam 1 questions with verified correct answers
,Gai - AC - dec
Gaq - PLC - inc
Talk through the steps of the cascade involving cAMP - CORRECT ANSWER-The
signal transduction cascade begins when adenylyl cyclase, a membrane- bound
enzyme, is activated by G-protein molecules associated with the adrenergic
receptor. Adenylyl cyclase creates multiple cyclic AMP molecules, which fan out
and activate protein kinases (PKA, in this example). Protein kinases can enter the
nucleus and affect transcription.
Name the 5 intracellular events that are regulated by PKA. - CORRECT ANSWER-1.
Phosphorylase PKA Kinase (Glycogen Breakdown)
2. L-Type Ca Channels (Heart Contraction)
3. Pyruvate Kinase (Glycolysis)
4. Hormone Sensitive Lipase (Triglyceride Breakdown)
5. CREB (Gene Transcription)
Describe the pathways that lead to protein phosphorylation via IP3 and DAG. -
CORRECT ANSWER-DAG
1. GPCR and activated by GTP binding --> activation of Phopholipase C (bound to
B) --> act of DAG --> act PKC --> prot phospho
IP3
1. GPCR and activated by GTP binding --> activation of Phopholipase C (bound to
B) --> IP3 --> Ca2+ release --> effect --> prot phophorylation
GMS6552 Exam 1 questions with verified correct answers
, What type of receptor is typically most dominant in the presence of multiple? -
CORRECT ANSWER-Inhibitory
What are the target enzymes of receptors? - CORRECT ANSWER-Guanylate
cyclase and Gprots
After Guanylate cyclase is activated what are the second messengers, protein
kinases, and effects that follow? - CORRECT ANSWER-Guanylate cyclase
cGMP
PKG
Contractile proteins and ion channels
What 3 things do Gprots activate? - CORRECT ANSWER-adenylate cyclase
Phospholipase C
Phospholipase A
After adenylate cyclase is activated what are the second messengers, protein
kinases, and effects that follow? - CORRECT ANSWER-adenylate cyclase
cAMP
PKA
Enzymes&transport pros, and ion channels
After Phospholipase C is activated what are the second messengers, protein
kinases, and effects that follow? - CORRECT ANSWER-Phospholipase C
IP3
inc Ca release
GMS6552 Exam 1 questions with verified correct answers
VERIFIED CORRECT ANSWERS
4 receptor types in order of their speed - CORRECT ANSWER-1. Channel-linked
(inotropic) - millisecs
2. G-prot coupled rec - seconds
3. Kinase linked - minutes
4. Nuclear rec - hours
What is a common example of a Channel-linked (inotropic) receptor? - CORRECT
ANSWER-nicotinic
ACh receptor
What is a common example of a G-prot coupled receptor? - CORRECT ANSWER-
Muscarinic ACh Receptor
What is a common example of a Kinase linked receptor? - CORRECT ANSWER-
Insulin Receptor
What is a common example of a Nuclear rec receptor? - CORRECT ANSWER-
Estrogen Receptor
What are 4 examples of GPCR ligands? - CORRECT ANSWER-Hormones,
Neurotransmitters, Chemokines, Ions, Amino acids, Peptides,
What are the 3 main Ga proteins? - CORRECT ANSWER-Gas- AC - inc
GMS6552 Exam 1 questions with verified correct answers
,Gai - AC - dec
Gaq - PLC - inc
Talk through the steps of the cascade involving cAMP - CORRECT ANSWER-The
signal transduction cascade begins when adenylyl cyclase, a membrane- bound
enzyme, is activated by G-protein molecules associated with the adrenergic
receptor. Adenylyl cyclase creates multiple cyclic AMP molecules, which fan out
and activate protein kinases (PKA, in this example). Protein kinases can enter the
nucleus and affect transcription.
Name the 5 intracellular events that are regulated by PKA. - CORRECT ANSWER-1.
Phosphorylase PKA Kinase (Glycogen Breakdown)
2. L-Type Ca Channels (Heart Contraction)
3. Pyruvate Kinase (Glycolysis)
4. Hormone Sensitive Lipase (Triglyceride Breakdown)
5. CREB (Gene Transcription)
Describe the pathways that lead to protein phosphorylation via IP3 and DAG. -
CORRECT ANSWER-DAG
1. GPCR and activated by GTP binding --> activation of Phopholipase C (bound to
B) --> act of DAG --> act PKC --> prot phospho
IP3
1. GPCR and activated by GTP binding --> activation of Phopholipase C (bound to
B) --> IP3 --> Ca2+ release --> effect --> prot phophorylation
GMS6552 Exam 1 questions with verified correct answers
, What type of receptor is typically most dominant in the presence of multiple? -
CORRECT ANSWER-Inhibitory
What are the target enzymes of receptors? - CORRECT ANSWER-Guanylate
cyclase and Gprots
After Guanylate cyclase is activated what are the second messengers, protein
kinases, and effects that follow? - CORRECT ANSWER-Guanylate cyclase
cGMP
PKG
Contractile proteins and ion channels
What 3 things do Gprots activate? - CORRECT ANSWER-adenylate cyclase
Phospholipase C
Phospholipase A
After adenylate cyclase is activated what are the second messengers, protein
kinases, and effects that follow? - CORRECT ANSWER-adenylate cyclase
cAMP
PKA
Enzymes&transport pros, and ion channels
After Phospholipase C is activated what are the second messengers, protein
kinases, and effects that follow? - CORRECT ANSWER-Phospholipase C
IP3
inc Ca release
GMS6552 Exam 1 questions with verified correct answers
