Top Mark Questions and Correct Verified Answers
ACRN Study Set Questions and Correct
Verified Answers
Lipoatrophy, the subcutaneous fat wasting of the face and buttocks, is believed to be
caused by which of the following antiretroviral medication?
- Tenofovir alafenamide (TAF)
- Tenofovir (TDF)
- Abacavir (ABC)
- Zidivodine (ZDV)
✓ Zidivodine (ZDV)
Proximal renal tubulopathy and elevated creatinine are an adverse event related to the
use of what antiretroviral medication?
- Tenofovir (TDF)
- Tenofovir alafenamide (TAF)
- Triumeq (ABC+3TC+DTG)
- Dolutegravir (DTG)
✓ Tenofovir (TDF)
Top Mark !!!
, Top Mark Questions and Correct Verified Answers
If a person with HIV infection has painless flesh-colored papules over the face and neck,
which of the following dermatological conditions should be suspected?
- Molluscum contagiosum
- Psoriasis
- Kaposi's sarcoma
- Seborrhea
✓ Molluscum contagiosum
What adverse event is related to the use of Abacavir?
- Myocardial infarction, ischemic stroke
- Central nervous system/neuropsychiatric symptoms
- Dyslipidemia
- Cardiac QTc interval Prolongation
✓ Myocardial infarction, ischemic stroke
You have a patient who newly diagnosed with HIV and HCV. She tells you that she is
interested in pursuing treatment for HCV immediately as she has a friend who
Top Mark !!!
, Top Mark Questions and Correct Verified Answers
experienced complications from the disease. Which circumstance would most strongly
warrant the deferment of HCV treatment for this patient?
- Your patient's CD4 is <200 cells/mm3
- Your patient is an active intravenous drug user
- Your patient is on opiod substitution therapy (OST) (methadone/buprenorphine) and
you are concerned about potential drug-drug interactions
- Your patient has advanced liver fibrosis
✓ Your patient's CD4 is <200 cells/mm3
✓
✓ Rationale: Improved immune status should be the priority for patients with a
CD4 count below 200 cells/mm3. Research shows us that patients with active
substance abuse do not have worse rates of SVR as compared to patients
without active substance abuse. However, these patients will likely need
increased support and adherence follow up. There are not significant drug-drug
interactions between DAAs and OST. References: U.S. Department of Health
and Human Services. 2017. Guidelines for the Use of Antiretroviral Agents in
Adults and Adolescents Living with HIV: Considerations for Antiretroviral Use in
Patients with Coinfections.
Your patient, who is co-infected with HIV/HBV, wants to know if she can start taking
what she heard is the "newer, safer" version of tenofovir disoproxil fumarate (TDF),
tenofovir alafenamide (TAF), instead. You explain:
Top Mark !!!
, Top Mark Questions and Correct Verified Answers
- TAF is not currently FDA approved for the treatment of HBV
- TAF is currently FDA approved for the treatment of HIV/HBV coinfection
- TAF is not currently FDA approved for the treatment of HIV/HBV coinfection
- TAF is currently FDA approved only for PrEP
✓ TAF is currently FDA approved for the treatment of HIV/HBV coinfection
✓
✓ Rationale: While switching from TDF to TAF is acceptable and preferable in
many cases, per DHHS guidelines (2017), discontinuation of ART with anti-HBV
activity may cause serious hepatocellular damage resulting from reactivation of
HBV. Therefore, DHHS recommends that patients should be advised against
stopping these medications and be carefully monitored during interruptions in
HBV treatment. References: U.S. Department of Health and Human Services.
2017. Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents
Living with HIV: Considerations for Antiretroviral Use in Patients with
Coinfections.
What antiretroviral therapy needs to be taken with a meal containing 400 calories or
more?
- Atripla
- Triumeq
- Stribild
- Complera
Top Mark !!!
ACRN Study Set Questions and Correct
Verified Answers
Lipoatrophy, the subcutaneous fat wasting of the face and buttocks, is believed to be
caused by which of the following antiretroviral medication?
- Tenofovir alafenamide (TAF)
- Tenofovir (TDF)
- Abacavir (ABC)
- Zidivodine (ZDV)
✓ Zidivodine (ZDV)
Proximal renal tubulopathy and elevated creatinine are an adverse event related to the
use of what antiretroviral medication?
- Tenofovir (TDF)
- Tenofovir alafenamide (TAF)
- Triumeq (ABC+3TC+DTG)
- Dolutegravir (DTG)
✓ Tenofovir (TDF)
Top Mark !!!
, Top Mark Questions and Correct Verified Answers
If a person with HIV infection has painless flesh-colored papules over the face and neck,
which of the following dermatological conditions should be suspected?
- Molluscum contagiosum
- Psoriasis
- Kaposi's sarcoma
- Seborrhea
✓ Molluscum contagiosum
What adverse event is related to the use of Abacavir?
- Myocardial infarction, ischemic stroke
- Central nervous system/neuropsychiatric symptoms
- Dyslipidemia
- Cardiac QTc interval Prolongation
✓ Myocardial infarction, ischemic stroke
You have a patient who newly diagnosed with HIV and HCV. She tells you that she is
interested in pursuing treatment for HCV immediately as she has a friend who
Top Mark !!!
, Top Mark Questions and Correct Verified Answers
experienced complications from the disease. Which circumstance would most strongly
warrant the deferment of HCV treatment for this patient?
- Your patient's CD4 is <200 cells/mm3
- Your patient is an active intravenous drug user
- Your patient is on opiod substitution therapy (OST) (methadone/buprenorphine) and
you are concerned about potential drug-drug interactions
- Your patient has advanced liver fibrosis
✓ Your patient's CD4 is <200 cells/mm3
✓
✓ Rationale: Improved immune status should be the priority for patients with a
CD4 count below 200 cells/mm3. Research shows us that patients with active
substance abuse do not have worse rates of SVR as compared to patients
without active substance abuse. However, these patients will likely need
increased support and adherence follow up. There are not significant drug-drug
interactions between DAAs and OST. References: U.S. Department of Health
and Human Services. 2017. Guidelines for the Use of Antiretroviral Agents in
Adults and Adolescents Living with HIV: Considerations for Antiretroviral Use in
Patients with Coinfections.
Your patient, who is co-infected with HIV/HBV, wants to know if she can start taking
what she heard is the "newer, safer" version of tenofovir disoproxil fumarate (TDF),
tenofovir alafenamide (TAF), instead. You explain:
Top Mark !!!
, Top Mark Questions and Correct Verified Answers
- TAF is not currently FDA approved for the treatment of HBV
- TAF is currently FDA approved for the treatment of HIV/HBV coinfection
- TAF is not currently FDA approved for the treatment of HIV/HBV coinfection
- TAF is currently FDA approved only for PrEP
✓ TAF is currently FDA approved for the treatment of HIV/HBV coinfection
✓
✓ Rationale: While switching from TDF to TAF is acceptable and preferable in
many cases, per DHHS guidelines (2017), discontinuation of ART with anti-HBV
activity may cause serious hepatocellular damage resulting from reactivation of
HBV. Therefore, DHHS recommends that patients should be advised against
stopping these medications and be carefully monitored during interruptions in
HBV treatment. References: U.S. Department of Health and Human Services.
2017. Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents
Living with HIV: Considerations for Antiretroviral Use in Patients with
Coinfections.
What antiretroviral therapy needs to be taken with a meal containing 400 calories or
more?
- Atripla
- Triumeq
- Stribild
- Complera
Top Mark !!!
