CPHON REVIEW; CHEMOTHERAPY
REVIEW EXAM
Cyclophosphamide - ANSWER Requires IV hydration and mesna before high
dosing and post-high dosing
Vincristine - ANSWER Fatal with a CNS block with intrathecal administration
Busulfan - ANSWER Requires prophylactic anticonvulsant therapy for high-
dose clients
Busulfan - ANSWER Requires PK studies
Temozolomide - ANSWER Only to be compounded with applesauce or apple
juice
Procarbazine - ANSWER Hypertension and/or CNS depression may occur in
the presence of alcohol, (MAO) inhibitors, phenothiazines, dilantin, tricyclic
antidepressants, barbiturates and tyramine-rich food (aged cheeses, wine,
bananas, yogurt and chocolate)
Carboplatin - ANSWER Nephrotoxicity and ototoxicity
Oxaliplatin - ANSWER Avoid cold drinks/food during administration
, Vincristine - ANSWER Loss of deep tendon reflexes
Constipation
Jaw Pain
Paclitaxel - ANSWER Premedicate with Benadryl, dexamethasone and an H2-
receptor blocker
Etoposide - ANSWER Monitor for hypotension
Irinotecan - ANSWER Major side effect is diarrhea
Treat early onset diarrhea with atropine and late onset diarrhea with loperamide
Doxorubicin - ANSWER Monitor cardiac function
Mitoxantrone - ANSWER Turns urine green
Bleomycin - ANSWER Can cause pulmonary fibrosis
Should never scuba dive
Methotrexate - ANSWER Discontinue bactrim with high dose administration
Cytarabine - ANSWER Steroid eye drops to prevent conjunctivitis when
giving in high IV doses
REVIEW EXAM
Cyclophosphamide - ANSWER Requires IV hydration and mesna before high
dosing and post-high dosing
Vincristine - ANSWER Fatal with a CNS block with intrathecal administration
Busulfan - ANSWER Requires prophylactic anticonvulsant therapy for high-
dose clients
Busulfan - ANSWER Requires PK studies
Temozolomide - ANSWER Only to be compounded with applesauce or apple
juice
Procarbazine - ANSWER Hypertension and/or CNS depression may occur in
the presence of alcohol, (MAO) inhibitors, phenothiazines, dilantin, tricyclic
antidepressants, barbiturates and tyramine-rich food (aged cheeses, wine,
bananas, yogurt and chocolate)
Carboplatin - ANSWER Nephrotoxicity and ototoxicity
Oxaliplatin - ANSWER Avoid cold drinks/food during administration
, Vincristine - ANSWER Loss of deep tendon reflexes
Constipation
Jaw Pain
Paclitaxel - ANSWER Premedicate with Benadryl, dexamethasone and an H2-
receptor blocker
Etoposide - ANSWER Monitor for hypotension
Irinotecan - ANSWER Major side effect is diarrhea
Treat early onset diarrhea with atropine and late onset diarrhea with loperamide
Doxorubicin - ANSWER Monitor cardiac function
Mitoxantrone - ANSWER Turns urine green
Bleomycin - ANSWER Can cause pulmonary fibrosis
Should never scuba dive
Methotrexate - ANSWER Discontinue bactrim with high dose administration
Cytarabine - ANSWER Steroid eye drops to prevent conjunctivitis when
giving in high IV doses
