G-Proteins Q&A
G proteins: - (correct answer)Ubiquitous large Guanyl nucleotide-binding proteins
These connect the 7-pass receptor proteins on cell surface with intracellular effector
protein - (correct answer)G-Proteins
G-protein linked receptors are classically called - (correct answer)serpentine receptors
G-proteins consist of - (correct answer)3 heterotrimeric subunits: alpha, beta, gamma
alpha subunit of G-protein can bind to _______ and posesses ____________ - (correct
answer)GDP and GTP.......... intrinsic slow GTPase activity
In the inactive form all three subunits are bound together and bound to GDP and in the
active form... - (correct answer)GTP replaces GDP and the subunits dissasociate
allowing the alpha subunit to diffuse freely along the membrane
G-Protein receptor is activated by - (correct answer)hormone-receptor interactions
the alpha subunit of the G-protein receptor confers - (correct answer)specificity of action
G-protein may stimulate/inhibit adenylate cyclase activity depending on the chemical
and - (correct answer)its binding position g-alpha:(s) or g-alpha:(i)
G-proteins have been identified in (tissues) - (correct answer)brain neurons, smooth
muscle of blood vessels, olfactory sensory neurons, light-sensitive cells of the eye
The binding of GTP ___________ G protein dissaociation and ______________ of the
alpha subunit for adenylate cyclase - (correct answer)favors.....enhances the affinity
G proteins: - (correct answer)Ubiquitous large Guanyl nucleotide-binding proteins
These connect the 7-pass receptor proteins on cell surface with intracellular effector
protein - (correct answer)G-Proteins
G-protein linked receptors are classically called - (correct answer)serpentine receptors
G-proteins consist of - (correct answer)3 heterotrimeric subunits: alpha, beta, gamma
alpha subunit of G-protein can bind to _______ and posesses ____________ - (correct
answer)GDP and GTP.......... intrinsic slow GTPase activity
In the inactive form all three subunits are bound together and bound to GDP and in the
active form... - (correct answer)GTP replaces GDP and the subunits dissasociate
allowing the alpha subunit to diffuse freely along the membrane
G-Protein receptor is activated by - (correct answer)hormone-receptor interactions
the alpha subunit of the G-protein receptor confers - (correct answer)specificity of action
G-protein may stimulate/inhibit adenylate cyclase activity depending on the chemical
and - (correct answer)its binding position g-alpha:(s) or g-alpha:(i)
G-proteins have been identified in (tissues) - (correct answer)brain neurons, smooth
muscle of blood vessels, olfactory sensory neurons, light-sensitive cells of the eye
The binding of GTP ___________ G protein dissaociation and ______________ of the
alpha subunit for adenylate cyclase - (correct answer)favors.....enhances the affinity
