Exam 1: NURS 615/ NURS615 (New 2024/ 2025 Update) Advanced Pharmacotherapeutics Review with Qs & As| 100% Correct| Grade A (Verified Answers) - Maryville

ExamI1:INURSI615/INURS615I(New
IUpdate)IAdvancedI
PharmacotherapeuticsICompleteIReviewI
withIQsI&IAs|I100%ICorrect|IGradeIAI
(VerifiedIAnswers)-IMaryville
QUESTION
IdentifyIdrugImetabolismIandItheIroleIofItheIisoenzymesIofItheIP450Isystem.


Answer:
ICYPsIareItheImajorIenzymeIinvolvedIinIdrugImetabolismIaccountIforI75%IofItotalImetabolis
mI

MostIdrugsIdeactivatedIareIdirectlyIaffectedIorIfacilitatedIbyICYPIexcretionIfromItheIbody

ManyIsubstancesIbioactivatedIbyICYPsItoIformIactiveIcompounds

ManyIdrugsIincreaseIorIdecreaseItheIactivityIofIvariousIisoactiveIenzymesIbyIinducingIbiosynt
hesisIofItheIisozymeI(enzymeIinduction)IorIbyIdirectlyIinhibitingItheIactivityIofICYPI(enzyme
Iinhibition)I

MAJORISOURCEIOFIADVERSEIDRUGIREACTIONSIchangesIinICYPIactivityIaffectImetab
olismIandIclearanceIofIvariousIdrugs

InteractionsIbetweenItwoImedsIcanIleadItoItoxicityIprescribersImayIneedItoIadjustIdosagesIorI
chooseIdrugsIthatIdoInotIinteractI

IMPORTANTIINIDRUGSIw/ISMALLITHERAPEUTICIWINDOWS

Example:IAntiepileticIdrugsI&IAmiodarone,IGrapefruitIjuiceI&ImedicationsIleadingItoIincreas
eIbioavailabilityIandIoverdose




QUESTION
WhatIisItheIefficacyIofItheIdrug?

,Answer:
IMaximumIresponseIachievableIfromIaIdrug

IntrinsicIactivityI
Effectiveness--abilityItoIproduceIbeneficialIeffect




QUESTION
OnItheIdrugIconcentrationIcurveIwhatIisItheIfirstIsignIofIaItherapeuticIeffect?


Answer:
ITheIonsetIofIaction




QUESTION
WhatIisItheIpurposeIofIaIpeakIandItroughIlevel?


Answer:
IToIdetermineIifIdrugIisIinItherapeuticIrangeIrefersItoIdosageIrangeIorIserumIconcentration.ISo
meIpatientsIrequireImoreIorIlessIthanIthisIrange.ISomeImayIexperienceItoxicityIwithinIthisIran
ge




QUESTION
DescribeItheIpurposeIofItheIbloodIbrainIbarrierIandItheIfetalIplacentalIbarrier.


Answer:
IBBB:IHighlyIselectiveIpermeableImembraneIthatIprotectsItheICNSIconnectedIbyItightIjunctio
nsIbrainIandIethelialIcells

AllowsItheIpassageIofIwater,IsomeIgases,IlipidIsolubleIfluidsIwithIpassiveIdiffusion

GlucoseIandIaminoIacidsIareIallowedItoIcross

, FPB:IImpedesIcertainIchemicalsImostIfatIsolubleIchemicalsIcanIcross
MoreIwaterIsolubleIdrugsIandIhigherImolecularIweightICANNOTIcross.IIfIdrugIbindsItoIlarge
ImoleculeIsuchIasIalbuminIitIwillInotIcross




QUESTION
HowIwillIrenalIinsufficiencyIaffectIdrugIelimination?


Answer:
IKidneyIprimaryIorganIofIexcretionI

RateIdependsIonIrenalIbloodIflowIGFRI(glomerularIfiltrationIrate)

renalIfunctionItestedIbyIcreatinine




QUESTION
AccordingItoItheIWHO,IwhatIisItheIfirstIstepIinItheIprescribingIprocess?


Answer:
IDefineIpatient'sIproblemItoIdetermineIaIclearIindicationIforItreatment

ConsiderIotherImedications,Iallergies,Ipregnancy,Icomorbidities

SummaryIofIdiagnosticIpartIofIconsultationI

SECONDISTEP:ITherapeuticIobjective;IincludesImonitoringItherapeuticItreatment

THIRD:IChooseIdrugIorIstepIneededI(a)IselectionIofIprofessionalIpersonalIdrugIofIfirstIchoice
I(b)IconfirmationIofIsuitabilityIforIpatientIinIquestionI
IncludesIcheckingIforIcontraindications

FOURTH:IMakingIaIchoiceIandIwritingIRxIstartingItreatment

FIFTH:IGivingIpatientIinstructionsIandIwarningIaboutItreatment

SIXTH:IMonitoringIEffectiveITreatmentI(continue,Iadjust,IstopItreatment?)