EMILLECT 2024/2025 ACADEMIC YEAR ©2024 EMILLECT. ALL RIGHTS RESERVED FIRST PUBLISH OCTOBER, 2024
CMN 548 Unit 5 Study Guide with
Complete Solutions
Potency - Answer✔✔-refers to the relative dose required to achieve certain effects, not to the
efficacy of a drug
Agonist (full agonist) - Answer✔✔-A drug that binds to a specific receptor producing an effect
identical to that usually produced by the neurotransmitter affecting that receptor
Pharmacodynamics - Answer✔✔-The time course and intensity of a drug's effect/what the drug
does to the body
Pharmacokinetics - Answer✔✔-What the body does to a drug
Tolerance - Answer✔✔-Develops over time a need to use increased doses of a medication/drug
to maintain a clinical effect. Or, a decreased sensitivity to adverse effects of a drug
Stevens-Johnson Syndrome - Answer✔✔-A systemic, immune-mediated reaction that can be
fatal or result in permanent scarring or blindness
Antagonist - Answer✔✔-A compound that blinds to a receptor that blocks or reduces the action
of another substance at the receptor site
Hyponatremia - Answer✔✔-Common symptoms of this medication side effect include
confusion, agitation, and lethargy. (tx with oxcarbazepine & SSRIs)
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,EMILLECT 2024/2025 ACADEMIC YEAR ©2024 EMILLECT. ALL RIGHTS RESERVED FIRST PUBLISH OCTOBER, 2024
Therapeutic index - Answer✔✔-ratio of the median toxic dose to the median effective dose
Somnolence - Answer✔✔-Daytime sleepiness
Black Box Warning - Answer✔✔-This warning reflects that a medication may cause a serious or
even life-threatening side effect
Partial or Mixed Agonist - Answer✔✔-A compound that elicits a partial pharmacological
response at the receptor site involved
Remission - Answer✔✔-The degree of improvement to below the syndromal threshold of a
disorder
Paradoxical - Answer✔✔-A response to a drug that represents the clinical effect opposite of
what is expected
Inverse agonist - Answer✔✔-An agent that binds to the same receptor site as an agonist but
produces the opposite pharmacological effect
4 major transmitters - Answer✔✔-Dopamine, Serotonin, GABA, Norepinephrine
Dopamine transmitter affects? - Answer✔✔-affects mood, Psychosis, ADHD, Addiction
Serotonin transmitter affects? - Answer✔✔-Depression, aggression, OCD, Panic, GAD, Social
Anxiety, PTSD, Violence, Sexual dysfunction, substance addiction
Norepinephrine affects? - Answer✔✔-Affects mood, anxiety, psychosis, ADHD (part), drug
withdrawal
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GABA affects? - Answer✔✔-Fear, anxiety, worry
Irreversible MAOIs Types - Answer✔✔-MAOa and MAOb
Irreversible MAOIs medications - Answer✔✔-Phenelzine (Nardil)
isocarboxazid (Marplan)
tranylcypromine (Parnate)
A single dose of MAOIs may persist in its inhibition of MAO for how long? - Answer✔✔-because
they irreversibly inactivate MAOs, the therapeutic effect of a single dose of irreversible MAOIs
may persist for as long as 2 weeks
What are the most frequent adverse effects of MAOIs? - Answer✔✔-orthostatic hypotension,
insomnia, weight gain, edema, sexual dysfunction
Reversible MAOIs (RIMAs) medications? - Answer✔✔-Moclobemide (Maerix)
How long will it take to recover MAO activity after a final dose of RIMA? - Answer✔✔-MAO
activity recovers completely 24-48 hrs after the last dose of a RIMA
MAOIs are used to treat what conditions? - Answer✔✔-depression
panic disorder
social phobia
bulimia nervosa
ptsd
Page 3/32
, EMILLECT 2024/2025 ACADEMIC YEAR ©2024 EMILLECT. ALL RIGHTS RESERVED FIRST PUBLISH OCTOBER, 2024
anginal pain
atypical facial pain
migraine
adhd
idiopathic orthostatic hypotension
Depression associated with TBI
Treatment for MAOI induced orthostatic hypotension? - Answer✔✔-Avoid caffeine
intake of 2L of fluid/day
addition of dietary salt
adjust HTN meds
support stocking
severe cases *tx with fludrocortisone (Florinef) a mineralcorticoid
How long should the NP wait to begin another tx for depression when stopping an MAOI to
begin another MAOI or SSRI? - Answer✔✔-irreversible MAOI-wait 14 days
MAO activity recovers completely 24-48 hrs after last dose of RIMA
How long should the NP wait to begin an MAOI after d/c a pt from fluoxetine (Prozac)? -
Answer✔✔-when switching from an antidepressant to an irreversible MAOI-should wait 10-14
days (or 5 weeks for fluoxetine (Prozac) before starting use of MAOI to avoid drug interactions
Page 4/32
CMN 548 Unit 5 Study Guide with
Complete Solutions
Potency - Answer✔✔-refers to the relative dose required to achieve certain effects, not to the
efficacy of a drug
Agonist (full agonist) - Answer✔✔-A drug that binds to a specific receptor producing an effect
identical to that usually produced by the neurotransmitter affecting that receptor
Pharmacodynamics - Answer✔✔-The time course and intensity of a drug's effect/what the drug
does to the body
Pharmacokinetics - Answer✔✔-What the body does to a drug
Tolerance - Answer✔✔-Develops over time a need to use increased doses of a medication/drug
to maintain a clinical effect. Or, a decreased sensitivity to adverse effects of a drug
Stevens-Johnson Syndrome - Answer✔✔-A systemic, immune-mediated reaction that can be
fatal or result in permanent scarring or blindness
Antagonist - Answer✔✔-A compound that blinds to a receptor that blocks or reduces the action
of another substance at the receptor site
Hyponatremia - Answer✔✔-Common symptoms of this medication side effect include
confusion, agitation, and lethargy. (tx with oxcarbazepine & SSRIs)
Page 1/32
,EMILLECT 2024/2025 ACADEMIC YEAR ©2024 EMILLECT. ALL RIGHTS RESERVED FIRST PUBLISH OCTOBER, 2024
Therapeutic index - Answer✔✔-ratio of the median toxic dose to the median effective dose
Somnolence - Answer✔✔-Daytime sleepiness
Black Box Warning - Answer✔✔-This warning reflects that a medication may cause a serious or
even life-threatening side effect
Partial or Mixed Agonist - Answer✔✔-A compound that elicits a partial pharmacological
response at the receptor site involved
Remission - Answer✔✔-The degree of improvement to below the syndromal threshold of a
disorder
Paradoxical - Answer✔✔-A response to a drug that represents the clinical effect opposite of
what is expected
Inverse agonist - Answer✔✔-An agent that binds to the same receptor site as an agonist but
produces the opposite pharmacological effect
4 major transmitters - Answer✔✔-Dopamine, Serotonin, GABA, Norepinephrine
Dopamine transmitter affects? - Answer✔✔-affects mood, Psychosis, ADHD, Addiction
Serotonin transmitter affects? - Answer✔✔-Depression, aggression, OCD, Panic, GAD, Social
Anxiety, PTSD, Violence, Sexual dysfunction, substance addiction
Norepinephrine affects? - Answer✔✔-Affects mood, anxiety, psychosis, ADHD (part), drug
withdrawal
Page 2/32
,EMILLECT 2024/2025 ACADEMIC YEAR ©2024 EMILLECT. ALL RIGHTS RESERVED FIRST PUBLISH OCTOBER, 2024
GABA affects? - Answer✔✔-Fear, anxiety, worry
Irreversible MAOIs Types - Answer✔✔-MAOa and MAOb
Irreversible MAOIs medications - Answer✔✔-Phenelzine (Nardil)
isocarboxazid (Marplan)
tranylcypromine (Parnate)
A single dose of MAOIs may persist in its inhibition of MAO for how long? - Answer✔✔-because
they irreversibly inactivate MAOs, the therapeutic effect of a single dose of irreversible MAOIs
may persist for as long as 2 weeks
What are the most frequent adverse effects of MAOIs? - Answer✔✔-orthostatic hypotension,
insomnia, weight gain, edema, sexual dysfunction
Reversible MAOIs (RIMAs) medications? - Answer✔✔-Moclobemide (Maerix)
How long will it take to recover MAO activity after a final dose of RIMA? - Answer✔✔-MAO
activity recovers completely 24-48 hrs after the last dose of a RIMA
MAOIs are used to treat what conditions? - Answer✔✔-depression
panic disorder
social phobia
bulimia nervosa
ptsd
Page 3/32
, EMILLECT 2024/2025 ACADEMIC YEAR ©2024 EMILLECT. ALL RIGHTS RESERVED FIRST PUBLISH OCTOBER, 2024
anginal pain
atypical facial pain
migraine
adhd
idiopathic orthostatic hypotension
Depression associated with TBI
Treatment for MAOI induced orthostatic hypotension? - Answer✔✔-Avoid caffeine
intake of 2L of fluid/day
addition of dietary salt
adjust HTN meds
support stocking
severe cases *tx with fludrocortisone (Florinef) a mineralcorticoid
How long should the NP wait to begin another tx for depression when stopping an MAOI to
begin another MAOI or SSRI? - Answer✔✔-irreversible MAOI-wait 14 days
MAO activity recovers completely 24-48 hrs after last dose of RIMA
How long should the NP wait to begin an MAOI after d/c a pt from fluoxetine (Prozac)? -
Answer✔✔-when switching from an antidepressant to an irreversible MAOI-should wait 10-14
days (or 5 weeks for fluoxetine (Prozac) before starting use of MAOI to avoid drug interactions
Page 4/32
