What medications are used for prophylactic treatment of migraines? TCAs, BBLs,
triptans, AEDs (Divalproex)
Describe Serotonin 1B/1D receptor agonists - Sumatriptan (Imitrex)
- causes intracerebral vasoconstriction
-Used for abortive migraines
- Can cause chest tightness
- Teratogenic
- Do not take with ergots or other triptans
Describe ergot alkaloids - Ergotamine
- suppresses CHRP to block inflammation
- can cause toxicity
What is the purpose of adding epi to lido? Causes vasoconstriction, allows lido effects to
last longer, decreases risk of toxicity from lido
, PC707 Module 5 Questions And Answers
What medications are used to assist in ETOH withdrawal? Benzos, Carbamazepine
(AED), clonidine, BBLs
Describe Disulfiram (antabuse) aversion therapy Used to refrain from drinking, causes
acetaldehyde syndrome when any ETOH is involved. Patient must avoid all ETOH even
sauces/cough syrups/ alcohol applied to skin (i.e. perfume)
Describe Naltrexone (Revia) Pure opioid agonist, decreases cravings of ETOH and blocks
the reinforcing effects of ETOH, does not cause aversion
Describe acamprosate (Campral) Reduces unpleasant feelings brought on by avoiding
ETOH, does not cause aversion, not safe in pregnancy
What medication can help manage withdrawal symptoms? Clonidine (for both ETOH and
opioid)
What medications are used for long-term opioid addiction management? Opioid agonists
(methadone), opioid agonist-antagonists (buprenorphine), opioid antagonists (Naltrexone)