CLINICAL CHEM TEST BANK (FINAL EXAM) QUESTIONS AND
ANSWERS LATEST UPDATE 2024/2025 BEST RATED A+
1. The combination of squamous cell carcinoma antigen (SCCA) and CYFRA 21-1 test
results can be used to provide reliable laboratory data for the differential diagnosis of
which disease?
A. Nonsquamous cell lung carcinoma
B. Pancreatic cancer
C. Liver cancer
D. Pulmonary embolism - CORRECT ANSWERS A. Nonsquamous cell lung carcinoma
2. "A progressive systemic skeletal disease characterized by low bone mass and micro
architectural deterioration of bone tissue, with a consequent increase in bone fragility
and susceptible to fracture" describes which of the following diseases?
A. Osteosarcoma
B. Osteoporosis
C. Renal osteodystrophy
D. Paget's disease - CORRECT ANSWERS B. Osteoporosis
3. A markedly elevated serum AFP is associated with which of the following?
A. Ovarian cancer
B. Lung cancer
C. Hepatoma
D. Breast cancer - CORRECT ANSWERS C. Hepatoma
4. Which of the following is a sialylated Lewis blood group antigen associated with
colorectal cancer?
A. CA 125
B. CA 15-3
C. PSA
D. CA 19-9 - CORRECT ANSWERS D. CA 19-9
5. Which of the following biomarkers are elevated in advanced stages of breast cancer?
A. Total and free PSA
B. CEA and alpha-fetoprotein
C. CA 15-3 and CA 549
,CLINICAL CHEM TEST BANK (FINAL EXAM) QUESTIONS AND
ANSWERS LATEST UPDATE 2024/2025 BEST RATED A+
D. DUPAN-2 and Gastrin - CORRECT ANSWERS C. CA 15-3 and CA 549
6. Which tumor marker is associated with cancer of the urinary bladder?
A. CA 125
B. CA19-9
C. CA 50
D. Nuclear matrix protein - CORRECT ANSWERS D. Nuclear matrix protein
7. What is the primary clinical usefulness of measuring carcinoembryonic antigen?
A. Diagnosis of lung cancer
B. Diagnosis of colorectal cancer
C. Screening for breast cancer
D. Monitoring for recurrence of colon cancer - CORRECT ANSWERS D. Monitoring for
recurrence of colon cancer
8. Which of the following is used to assess the usefulness of trastuzumab (Herceptin®)
therapy for breast cancer?
A. CA 15-3
B. HER-2/neu
C. CA 125
D. Prolactin - CORRECT ANSWERS B. HER-2/neu
9. Which type of hCG test would be most useful to assess a person suspected of having
testicular cancer?
A. Plasma immunoassay for intact hCG and the β-hCG subunits
B. Plasma immunoassay fro the free alpha and β-hCG subunits
C. Urine assay for hCG-β core
D. Plasma immunoassay for intact hCG only - CORRECT ANSWERS A. Plasma
immunoassay for intact hCG and the β-hCG subunits
10. Which of the following biomarkers is elevated in nonmucinous epithelial ovarian
cancer?
A. CA 15-3
,CLINICAL CHEM TEST BANK (FINAL EXAM) QUESTIONS AND
ANSWERS LATEST UPDATE 2024/2025 BEST RATED A+
B. CA 19-9
C. CA 125
D. CEA - CORRECT ANSWERS C. CA 125
11. Which of the following assays is recommended as a screening test for colorectal
cancer in persons over 50 years of age?
A. Fecal typsin
B. AFP
C. BTA
D. Occult blood t test - CORRECT ANSWERS D. Occult blood test
12. Which of the following must be determined to calculate diagnostic specificity?
A. True-negatives and false-positives
B. True-positives and false-positives
C. True-positives and false-negatives
D. True-negatives and false-negatives - CORRECT ANSWERS A. True-negatives and false-
positives
13. A new tumor marker assay for prostate specific antigen (PSA) is evaluated for
sensitivity by testing serum samples from patients who have been diagnosed as having
prostate cancer. The following results were obtained:
Number of prostate cancer patients who tested positive by the new assay = 42 out 46
Number of patients who did not have cancer and tested negative by the new assay = 31
out of 32
What is the sensitivity of the new assay for PSA?
A. 98.0%
B. 95.0%
C. 91.3%
D. 88.5% - CORRECT ANSWERS C. 91.3%
14. Which statement below best describes the molecular difference between free PSA
(fPSA) and complex PSA (cPSA)?
A. Free PSA is bound by compounds such as ACT, PCI, API, or AMG
, CLINICAL CHEM TEST BANK (FINAL EXAM) QUESTIONS AND
ANSWERS LATEST UPDATE 2024/2025 BEST RATED A+
B. Free PSA is an active form that can complex with protease inhibitors
C. Free PSA is not bound by compounds such as ACT, PCI, API, or AMG
D. Free PSA cannot be detected in serum, whereas complex PSA can - CORRECT
ANSWERS C. Free PSA is not bound by compounds such as ACT, PCI, API, or AMG
15. The production of alpha fetal protein (AFP) in a healthy individual is best reflected
by which of the following statements?
A. The production of AFP remains the same through life
B. The production of AFP declines rapidly at birth and healthy adults and children have
negligible or undetectable levels in serum
C. The production of AFP declines rapidly at birth and healthy adults and children have
higher than normal levels in serum
D. The production of AFP declines rapidly at birth and healthy adults and children have
negligible or undetectable levels in serum - CORRECT ANSWERS D. The production of
AFP declines rapidly at birth and healthy adults and children have negligible or
undetectable levels in serum
16. In which of the following disorders would the maternal serum level of 1-fetoprotein
be elevated?
A. Neural tube defect.
B. Cardiac ischemia.
C. Down syndrome.
D. Small cell lung carcinoma - CORRECT ANSWERS A. Neural tube defect
17. A new test for breast cancer is found to have a sensitivity of 85.0% and a specificity
of 90.0%. If the prevalence of breast cancer is 3.5% in women over 45 years old, what is
the predictive value of a positive test result (PV+) in this group?
A. 60.0
B. 50.5
C. 30.0
D. 23.6 - CORRECT ANSWERS D. 23.6
18. Nuclear matrix protein-22 (NMP) is a tumor marker designed for what purpose?
A. Test for recurrence of bladder cancer
B. Test for recurrence of lung cancer
ANSWERS LATEST UPDATE 2024/2025 BEST RATED A+
1. The combination of squamous cell carcinoma antigen (SCCA) and CYFRA 21-1 test
results can be used to provide reliable laboratory data for the differential diagnosis of
which disease?
A. Nonsquamous cell lung carcinoma
B. Pancreatic cancer
C. Liver cancer
D. Pulmonary embolism - CORRECT ANSWERS A. Nonsquamous cell lung carcinoma
2. "A progressive systemic skeletal disease characterized by low bone mass and micro
architectural deterioration of bone tissue, with a consequent increase in bone fragility
and susceptible to fracture" describes which of the following diseases?
A. Osteosarcoma
B. Osteoporosis
C. Renal osteodystrophy
D. Paget's disease - CORRECT ANSWERS B. Osteoporosis
3. A markedly elevated serum AFP is associated with which of the following?
A. Ovarian cancer
B. Lung cancer
C. Hepatoma
D. Breast cancer - CORRECT ANSWERS C. Hepatoma
4. Which of the following is a sialylated Lewis blood group antigen associated with
colorectal cancer?
A. CA 125
B. CA 15-3
C. PSA
D. CA 19-9 - CORRECT ANSWERS D. CA 19-9
5. Which of the following biomarkers are elevated in advanced stages of breast cancer?
A. Total and free PSA
B. CEA and alpha-fetoprotein
C. CA 15-3 and CA 549
,CLINICAL CHEM TEST BANK (FINAL EXAM) QUESTIONS AND
ANSWERS LATEST UPDATE 2024/2025 BEST RATED A+
D. DUPAN-2 and Gastrin - CORRECT ANSWERS C. CA 15-3 and CA 549
6. Which tumor marker is associated with cancer of the urinary bladder?
A. CA 125
B. CA19-9
C. CA 50
D. Nuclear matrix protein - CORRECT ANSWERS D. Nuclear matrix protein
7. What is the primary clinical usefulness of measuring carcinoembryonic antigen?
A. Diagnosis of lung cancer
B. Diagnosis of colorectal cancer
C. Screening for breast cancer
D. Monitoring for recurrence of colon cancer - CORRECT ANSWERS D. Monitoring for
recurrence of colon cancer
8. Which of the following is used to assess the usefulness of trastuzumab (Herceptin®)
therapy for breast cancer?
A. CA 15-3
B. HER-2/neu
C. CA 125
D. Prolactin - CORRECT ANSWERS B. HER-2/neu
9. Which type of hCG test would be most useful to assess a person suspected of having
testicular cancer?
A. Plasma immunoassay for intact hCG and the β-hCG subunits
B. Plasma immunoassay fro the free alpha and β-hCG subunits
C. Urine assay for hCG-β core
D. Plasma immunoassay for intact hCG only - CORRECT ANSWERS A. Plasma
immunoassay for intact hCG and the β-hCG subunits
10. Which of the following biomarkers is elevated in nonmucinous epithelial ovarian
cancer?
A. CA 15-3
,CLINICAL CHEM TEST BANK (FINAL EXAM) QUESTIONS AND
ANSWERS LATEST UPDATE 2024/2025 BEST RATED A+
B. CA 19-9
C. CA 125
D. CEA - CORRECT ANSWERS C. CA 125
11. Which of the following assays is recommended as a screening test for colorectal
cancer in persons over 50 years of age?
A. Fecal typsin
B. AFP
C. BTA
D. Occult blood t test - CORRECT ANSWERS D. Occult blood test
12. Which of the following must be determined to calculate diagnostic specificity?
A. True-negatives and false-positives
B. True-positives and false-positives
C. True-positives and false-negatives
D. True-negatives and false-negatives - CORRECT ANSWERS A. True-negatives and false-
positives
13. A new tumor marker assay for prostate specific antigen (PSA) is evaluated for
sensitivity by testing serum samples from patients who have been diagnosed as having
prostate cancer. The following results were obtained:
Number of prostate cancer patients who tested positive by the new assay = 42 out 46
Number of patients who did not have cancer and tested negative by the new assay = 31
out of 32
What is the sensitivity of the new assay for PSA?
A. 98.0%
B. 95.0%
C. 91.3%
D. 88.5% - CORRECT ANSWERS C. 91.3%
14. Which statement below best describes the molecular difference between free PSA
(fPSA) and complex PSA (cPSA)?
A. Free PSA is bound by compounds such as ACT, PCI, API, or AMG
, CLINICAL CHEM TEST BANK (FINAL EXAM) QUESTIONS AND
ANSWERS LATEST UPDATE 2024/2025 BEST RATED A+
B. Free PSA is an active form that can complex with protease inhibitors
C. Free PSA is not bound by compounds such as ACT, PCI, API, or AMG
D. Free PSA cannot be detected in serum, whereas complex PSA can - CORRECT
ANSWERS C. Free PSA is not bound by compounds such as ACT, PCI, API, or AMG
15. The production of alpha fetal protein (AFP) in a healthy individual is best reflected
by which of the following statements?
A. The production of AFP remains the same through life
B. The production of AFP declines rapidly at birth and healthy adults and children have
negligible or undetectable levels in serum
C. The production of AFP declines rapidly at birth and healthy adults and children have
higher than normal levels in serum
D. The production of AFP declines rapidly at birth and healthy adults and children have
negligible or undetectable levels in serum - CORRECT ANSWERS D. The production of
AFP declines rapidly at birth and healthy adults and children have negligible or
undetectable levels in serum
16. In which of the following disorders would the maternal serum level of 1-fetoprotein
be elevated?
A. Neural tube defect.
B. Cardiac ischemia.
C. Down syndrome.
D. Small cell lung carcinoma - CORRECT ANSWERS A. Neural tube defect
17. A new test for breast cancer is found to have a sensitivity of 85.0% and a specificity
of 90.0%. If the prevalence of breast cancer is 3.5% in women over 45 years old, what is
the predictive value of a positive test result (PV+) in this group?
A. 60.0
B. 50.5
C. 30.0
D. 23.6 - CORRECT ANSWERS D. 23.6
18. Nuclear matrix protein-22 (NMP) is a tumor marker designed for what purpose?
A. Test for recurrence of bladder cancer
B. Test for recurrence of lung cancer
