OCN exam 100% Correct!!
Pegfilgrastim - Neulasta - ANSWER1 dose each cycle > 24 hours after chemo
Potential cardiovascular toxicities in a client receiving tx for cancer - ANSWER1- alteration in the
electrical conduction within the heart.
2. cardiomyopathy as the most common chronic cardiac toxicity
Asymptomatic bradycardia is likely to related to which of the following chemo agents - ANSWERPaclitaxel
(Paxen, Taxol)
Factors that are associated with increased risk of cardiotoxicity from chemo include - ANSWER1 high-
dose cyclophosphamide, RT to the chest, and multiple cardiotoxic drugs
2. high doses o potentially cardiotoxic chemo agents administered over relatively short periods of time.
Prevention of doxorubicin related cardiomyopathy includes - ANSWERexercise ad use of dexrazoxane
When the ejection fraction is less than 45% the nurse should expect - ANSWERdecrease in the dose of
cardiotoxic chemo agents
Which statements correctly identify the classification of chemo agents and their potential effects -
ANSWER1 Antimetabolites have the potential to cause coronary artery spasm, resulting in cardiac
related sudden death
2 Taxanes and some alkylating agents can cause early heart failure and left ventricular dysfunction
A client admitted with CHF. Records indicate hx of breast cancer treated with chemo and RT. The most
likely late effect of this treatment is - ANSWERcardiomyopathy caused by anthracycline therapy
major difference between the short acting and intermidiate and long acting corticosterioids -
ANSWERShort acting have greater sodium and water retention activity.
The major advantage of intermediate-
, acting corticosteroids is that they have minimal sodium- retaining activity; long-acting corticosteroids
have no sodium-retaining activity.
meperidine (demerol)-phenytoin (Dilantin) drug interaction - ANSWERreduced plasma levels of
meperidine
onset of action of fentanyl - ANSWERIV - 5-6 mins
Patch - 18-24 hours
Buccal 5-15 minutes
patient with brain mets may need to receive prophylactic phenytoin (dilantin) if receiving -
ANSWERprochlorperazine and meperidine
*Use of prochlorperazine and meperidine may lower seizure threshold
anxiolytic discontinuation may have risk - ANSWERpsychosis, seizures and coma
common s/e of SSRI - ANSWERsexual dysfunction
needs seizure related concern - ANSWERifosfamide, high dose methotrexate and busulifan
oprolvekin - ANSWERgrowth factor that stimulates platelet growth
Oprelvekin is still being evaluated for use
in cancer treatment.
The Food and Drug Administration has approved it to reduce plate- let transfusions caused by low
platelet nadirs.
Allergies to the product are not regarded a common problem at this time
1 has not been shown to decrease mortality rates
2 high cost and significant toxicity limit its use
3 Thrombocytopenia is typically managed with platelet transfusion
Pegfilgrastim - Neulasta - ANSWER1 dose each cycle > 24 hours after chemo
Potential cardiovascular toxicities in a client receiving tx for cancer - ANSWER1- alteration in the
electrical conduction within the heart.
2. cardiomyopathy as the most common chronic cardiac toxicity
Asymptomatic bradycardia is likely to related to which of the following chemo agents - ANSWERPaclitaxel
(Paxen, Taxol)
Factors that are associated with increased risk of cardiotoxicity from chemo include - ANSWER1 high-
dose cyclophosphamide, RT to the chest, and multiple cardiotoxic drugs
2. high doses o potentially cardiotoxic chemo agents administered over relatively short periods of time.
Prevention of doxorubicin related cardiomyopathy includes - ANSWERexercise ad use of dexrazoxane
When the ejection fraction is less than 45% the nurse should expect - ANSWERdecrease in the dose of
cardiotoxic chemo agents
Which statements correctly identify the classification of chemo agents and their potential effects -
ANSWER1 Antimetabolites have the potential to cause coronary artery spasm, resulting in cardiac
related sudden death
2 Taxanes and some alkylating agents can cause early heart failure and left ventricular dysfunction
A client admitted with CHF. Records indicate hx of breast cancer treated with chemo and RT. The most
likely late effect of this treatment is - ANSWERcardiomyopathy caused by anthracycline therapy
major difference between the short acting and intermidiate and long acting corticosterioids -
ANSWERShort acting have greater sodium and water retention activity.
The major advantage of intermediate-
, acting corticosteroids is that they have minimal sodium- retaining activity; long-acting corticosteroids
have no sodium-retaining activity.
meperidine (demerol)-phenytoin (Dilantin) drug interaction - ANSWERreduced plasma levels of
meperidine
onset of action of fentanyl - ANSWERIV - 5-6 mins
Patch - 18-24 hours
Buccal 5-15 minutes
patient with brain mets may need to receive prophylactic phenytoin (dilantin) if receiving -
ANSWERprochlorperazine and meperidine
*Use of prochlorperazine and meperidine may lower seizure threshold
anxiolytic discontinuation may have risk - ANSWERpsychosis, seizures and coma
common s/e of SSRI - ANSWERsexual dysfunction
needs seizure related concern - ANSWERifosfamide, high dose methotrexate and busulifan
oprolvekin - ANSWERgrowth factor that stimulates platelet growth
Oprelvekin is still being evaluated for use
in cancer treatment.
The Food and Drug Administration has approved it to reduce plate- let transfusions caused by low
platelet nadirs.
Allergies to the product are not regarded a common problem at this time
1 has not been shown to decrease mortality rates
2 high cost and significant toxicity limit its use
3 Thrombocytopenia is typically managed with platelet transfusion
