PHM Exam 2 Questions With Complete Solutions
A cannabinoid 1 receptor (CB1) antagonist was tested
unsuccessfully for the treatment of: Correct Answers Obesity
A cannabinoid 1 receptor (CB1) antagonist would be potentially
useful for the treatment of: Correct Answers Obesity
A cannabinoid receptor type 1 (CB1) receptor agonist would be
effective in treating which of the following disorders? Correct
Answers Muscle spasticity associated with multiple sclerosis
A drug which blocks which of the following receptors would
likely increase anxiety because it would inhibit NPY release
from neurons in the amygdala? Correct Answers CRF receptors
A laboratory rat is tested before and after alprazolam treatment
in the novelty suppressed feeding test (open field test) and the
alprazolam induced change in feeding latency is recorded. The
same rat is then treated with alcohol for 1 week and retested
with alprazolam in the novelty suppressed feeding test. What
would the anticipated results (and underlying mechanism) be
during the alprazolam retest? Correct Answers an increase in
feeding latency because of pharmacodynamic cross tolerance
between ethanol and alprazolam
A loss of function mutation in the gene that encodes the enzyme
aromotase will likely lead to: Correct Answers failure of bone
epiphyses fusion in males
, A loss of function mutation in the gene that encodes the enzyme
glucuronyl transferase will likely cause Correct Answers An
increase in the risk of a morphine overdose in patients having
the mutation if they were to receive morphine for pain relief
A morphine tolerant and dependent subject is given
intravenously an unknown drug that elicits a severe withdrawal
response within a few minutes of drug administration. A drug
most likely to produce this effect is: Correct Answers naloxone
A stable, long-lasting (>1 week) blood marker for marijuana use
by an individual is: Correct Answers THC-COOH
Acomprosate is a drug that used to treat which of the following
problems and by what mechanism? Correct Answers Reduces
anxiety associated with alcohol withdrawal by blocking NMDA
glutamate receptors
Alcohol and benzodiazepines both act on which brain area to
reduce anxiety Correct Answers amygdala
Alcohol is a drug with properties that differentiate it from other
abused drugs. These unique properties include: Correct
Answers Elimination occurs via zero order kinetics
An important stimulant of growth hormone release from the
pituitary gland is: Correct Answers Ghrelin
Androstenedione has been used to enhance athletic performance
because it: Correct Answers is a precursor of testosterone
synthesis
A cannabinoid 1 receptor (CB1) antagonist was tested
unsuccessfully for the treatment of: Correct Answers Obesity
A cannabinoid 1 receptor (CB1) antagonist would be potentially
useful for the treatment of: Correct Answers Obesity
A cannabinoid receptor type 1 (CB1) receptor agonist would be
effective in treating which of the following disorders? Correct
Answers Muscle spasticity associated with multiple sclerosis
A drug which blocks which of the following receptors would
likely increase anxiety because it would inhibit NPY release
from neurons in the amygdala? Correct Answers CRF receptors
A laboratory rat is tested before and after alprazolam treatment
in the novelty suppressed feeding test (open field test) and the
alprazolam induced change in feeding latency is recorded. The
same rat is then treated with alcohol for 1 week and retested
with alprazolam in the novelty suppressed feeding test. What
would the anticipated results (and underlying mechanism) be
during the alprazolam retest? Correct Answers an increase in
feeding latency because of pharmacodynamic cross tolerance
between ethanol and alprazolam
A loss of function mutation in the gene that encodes the enzyme
aromotase will likely lead to: Correct Answers failure of bone
epiphyses fusion in males
, A loss of function mutation in the gene that encodes the enzyme
glucuronyl transferase will likely cause Correct Answers An
increase in the risk of a morphine overdose in patients having
the mutation if they were to receive morphine for pain relief
A morphine tolerant and dependent subject is given
intravenously an unknown drug that elicits a severe withdrawal
response within a few minutes of drug administration. A drug
most likely to produce this effect is: Correct Answers naloxone
A stable, long-lasting (>1 week) blood marker for marijuana use
by an individual is: Correct Answers THC-COOH
Acomprosate is a drug that used to treat which of the following
problems and by what mechanism? Correct Answers Reduces
anxiety associated with alcohol withdrawal by blocking NMDA
glutamate receptors
Alcohol and benzodiazepines both act on which brain area to
reduce anxiety Correct Answers amygdala
Alcohol is a drug with properties that differentiate it from other
abused drugs. These unique properties include: Correct
Answers Elimination occurs via zero order kinetics
An important stimulant of growth hormone release from the
pituitary gland is: Correct Answers Ghrelin
Androstenedione has been used to enhance athletic performance
because it: Correct Answers is a precursor of testosterone
synthesis
