lOMoAR cPSD| 37417828
lOMoAR cPSD| 37417828
NR293 Pharmacology for Nursing Practice Week 4 Concepts
Pharmacology For Nursing Practice (Chamberlain University)
lOMoAR cPSD| 37417828
Week 4 Concepts: Clotting
Coagulation Modifiers
Prepare: Coagulation Modifiers
Coagulation Modifiers
Coagulation modifiers are a group of medications that both promote and prevent clot formation as well as lysing a preformed clot and
reversing the action of anticoagulants.
Warfarin
Warfarin is an anticoagulant medication whose mechanism of action is to prevent clot formation by inhibiting particular clotting facto
Coagulation Modifier Drugs
Coagulation modifier drugs is a class of medication that includes medications? heparin
aspirin acetaminophen
warfarin
Self Check: Hemostasis Review
Coagulation Cascade System
The coagulation cascade system is triggered by an injury to a blood vessel, which then triggers either an intrinsic or an extrinsic pathw
of intricate steps, each step triggering the next when clotting factors are/is activated. The ultimate result of this system is a large
concentration of fibrin.
Reverse of the Coagulation Process
The reverse of the coagulation process is the fibrinolytic system. Fibrinolysis is the breakdown of thrombi. This is an important part of
hemostasis in order to prevent excessive coagulation, blocked blood vessels, or mobilized thrombi called an embolus.
Self Check: Coagulation Modifier Drugs
Coagulation Modifiers
,The coagulation modifier drugs are broken down into several subclasses or categories based on their hemostasis reversal or
promotion action. Which items are mechanisms of action for this class of drug? Select all that apply.
Thrombus prevention
Thrombus mobilization
Lysing of a preformed thrombus
Anticoagulation reversal
Thrombus promotion
Antiplatelet reversal
Self Check: Mechanism of Action
Mechanism of Action
Which one of these coagulation modifier drugs has a mechanism of action that is to lyse a thrombus that has already formed? Matc
it to its subclass.
protamine sulfate vitamin
K
Reflect: Coagulation Modifiers
Antifibrinolytics
What is another term for antifibrinolytics?
Antithrombotics
Antiplatelets
Hemorheologics
Hemostatics
Promoting Coagulation
A coagulation modifier drug whose mechanism of action is to promote coagulation of the blood is called a(n) ___________
and is used to _________. antifibrinolytic, manage excessive bleeding anticoagulant, prevent clot formation
thrombolytic, lyse clots that have already formed antiplatelet,
interfere with platelet function
Anticoagulants
What is another term for anticoagulant?
Hemostatics
Antiplatelets
Hemorheologics
Antithrombotics
, lOMoAR cPSD| 37417828
Antifibrinolytics
Coagulation Modifier Drugs and Subclasses
Match the coagulation modifier drug’s subclass to the correct medications. Note: Several of the subclasses have more than one
medication listed as correct choices.
Reversal and Coagulation Modifier Drugs
Choose the correct word(s) from the drop-down list to complete the following statements regarding reversal drugs.
Protamine sulfate is the reversal drug for heparin.
Phytonadione is the reversal drug for warfarin.
Idarucizumab is the reversal drug for dabigatran etexilate.
Coagulation factor Xa (recombinant) is the reversal drug for rivaroxaban . lOMoARc PSD| 37417828
Indications for Use
Match the indications for use of coagulation modifying drugs by dragging the class on the right to the correct description.
Antiplatelet drugs inhibit platelet aggregation and formation of platelet plugs, which are helpful in preventing heart attacks and stroke
Hemorrhagic drugs alter platelet function without interfering with normal platelet activity.
Thrombolytic drugs are a classification of drugs that are used to break down clots or thrombi that have formed.
Antifibrinolytic drugs are hemostatic drugs that promote blood coagulation for conditions of excessive bleeding.
Hemostasis Vocabulary
From the drop-down menu, select the term that best fits the definition. The process
of thrombi formation – Coagulation
A clot forming substance that is the result of the coagulation system, which also triggers the fibrinolysis system – Fibrin The process
of thrombi breakdown – Fibrinolysis
A rare genetic disorder in which certain factors needed for coagulation and hemostasis are inadequate or nonexistent –
Hemophilia
Any process that stops bleeding – Hemostasis
Use of compression to achieve hemostasis – xxxMechanical means of hemostasis
Use of clamping or cauterization to achieve hemostasis – xxxSurgical means of hemostasis
,Use of coagulation modifier drugs to achieve hemostasis – xxxPharmacologic means of hemostasis A
mobilized thrombus – Embolus
Blood clot – Thrombus
Subclasses
Match the coagulation modifier drug’s subclass to its mechanism of action.
Prevent clot formation by inhibiting particular clotting factors Anticoagulants
Prevent clot formation by interfering with platelet function Antiplatelets
Lyse clots that have already formed Thrombolytics
Promote the coagulation of blood Antifibrinolytics
Reduce blood viscosity Hemorheologics
Act as antagonists to the other medications Reversal drugs
Anticoagulants (warfarin; heparin)
Prepare: Anticoagulants
Actions of Anticoagulants
Anticoagulants perform which of the following actions? Act directly
on platelet aggregation
Prevent thrombosis
Breakdown fibrin
Lyse pre-formed clots
Anticoagulant Subclasses
Which of these anticoagulants belongs to the subclass heparins?
clopidogrel warfarin rivaroxaban enoxaparin
Coumarins
How do coumarins prevent thrombus formation?
Working with other drug classes to decrease the thickness of blood
Inhibiting vitamin K-dependent clotting factors
Directly impacting platelet aggregation
Breaking down the fibrin in clots
Self Check: Thromboembolic Event
Which of the following patients is least at risk of a thromboembolic event?
Someone on a direct flight from Detroit, Michigan to Sydney, Australia
Someone who has been in a coma for a week following a stroke
Someone who has a broken foot and is learning to walk with an orthopedic boot
Someone who has a mechanical heart valve
Someone recovering from a bilateral knee replacement
lOMoAR cPSD| 37417828
NR293 Pharmacology for Nursing Practice Week 4 Concepts
Pharmacology For Nursing Practice (Chamberlain University)
lOMoAR cPSD| 37417828
Week 4 Concepts: Clotting
Coagulation Modifiers
Prepare: Coagulation Modifiers
Coagulation Modifiers
Coagulation modifiers are a group of medications that both promote and prevent clot formation as well as lysing a preformed clot and
reversing the action of anticoagulants.
Warfarin
Warfarin is an anticoagulant medication whose mechanism of action is to prevent clot formation by inhibiting particular clotting facto
Coagulation Modifier Drugs
Coagulation modifier drugs is a class of medication that includes medications? heparin
aspirin acetaminophen
warfarin
Self Check: Hemostasis Review
Coagulation Cascade System
The coagulation cascade system is triggered by an injury to a blood vessel, which then triggers either an intrinsic or an extrinsic pathw
of intricate steps, each step triggering the next when clotting factors are/is activated. The ultimate result of this system is a large
concentration of fibrin.
Reverse of the Coagulation Process
The reverse of the coagulation process is the fibrinolytic system. Fibrinolysis is the breakdown of thrombi. This is an important part of
hemostasis in order to prevent excessive coagulation, blocked blood vessels, or mobilized thrombi called an embolus.
Self Check: Coagulation Modifier Drugs
Coagulation Modifiers
,The coagulation modifier drugs are broken down into several subclasses or categories based on their hemostasis reversal or
promotion action. Which items are mechanisms of action for this class of drug? Select all that apply.
Thrombus prevention
Thrombus mobilization
Lysing of a preformed thrombus
Anticoagulation reversal
Thrombus promotion
Antiplatelet reversal
Self Check: Mechanism of Action
Mechanism of Action
Which one of these coagulation modifier drugs has a mechanism of action that is to lyse a thrombus that has already formed? Matc
it to its subclass.
protamine sulfate vitamin
K
Reflect: Coagulation Modifiers
Antifibrinolytics
What is another term for antifibrinolytics?
Antithrombotics
Antiplatelets
Hemorheologics
Hemostatics
Promoting Coagulation
A coagulation modifier drug whose mechanism of action is to promote coagulation of the blood is called a(n) ___________
and is used to _________. antifibrinolytic, manage excessive bleeding anticoagulant, prevent clot formation
thrombolytic, lyse clots that have already formed antiplatelet,
interfere with platelet function
Anticoagulants
What is another term for anticoagulant?
Hemostatics
Antiplatelets
Hemorheologics
Antithrombotics
, lOMoAR cPSD| 37417828
Antifibrinolytics
Coagulation Modifier Drugs and Subclasses
Match the coagulation modifier drug’s subclass to the correct medications. Note: Several of the subclasses have more than one
medication listed as correct choices.
Reversal and Coagulation Modifier Drugs
Choose the correct word(s) from the drop-down list to complete the following statements regarding reversal drugs.
Protamine sulfate is the reversal drug for heparin.
Phytonadione is the reversal drug for warfarin.
Idarucizumab is the reversal drug for dabigatran etexilate.
Coagulation factor Xa (recombinant) is the reversal drug for rivaroxaban . lOMoARc PSD| 37417828
Indications for Use
Match the indications for use of coagulation modifying drugs by dragging the class on the right to the correct description.
Antiplatelet drugs inhibit platelet aggregation and formation of platelet plugs, which are helpful in preventing heart attacks and stroke
Hemorrhagic drugs alter platelet function without interfering with normal platelet activity.
Thrombolytic drugs are a classification of drugs that are used to break down clots or thrombi that have formed.
Antifibrinolytic drugs are hemostatic drugs that promote blood coagulation for conditions of excessive bleeding.
Hemostasis Vocabulary
From the drop-down menu, select the term that best fits the definition. The process
of thrombi formation – Coagulation
A clot forming substance that is the result of the coagulation system, which also triggers the fibrinolysis system – Fibrin The process
of thrombi breakdown – Fibrinolysis
A rare genetic disorder in which certain factors needed for coagulation and hemostasis are inadequate or nonexistent –
Hemophilia
Any process that stops bleeding – Hemostasis
Use of compression to achieve hemostasis – xxxMechanical means of hemostasis
Use of clamping or cauterization to achieve hemostasis – xxxSurgical means of hemostasis
,Use of coagulation modifier drugs to achieve hemostasis – xxxPharmacologic means of hemostasis A
mobilized thrombus – Embolus
Blood clot – Thrombus
Subclasses
Match the coagulation modifier drug’s subclass to its mechanism of action.
Prevent clot formation by inhibiting particular clotting factors Anticoagulants
Prevent clot formation by interfering with platelet function Antiplatelets
Lyse clots that have already formed Thrombolytics
Promote the coagulation of blood Antifibrinolytics
Reduce blood viscosity Hemorheologics
Act as antagonists to the other medications Reversal drugs
Anticoagulants (warfarin; heparin)
Prepare: Anticoagulants
Actions of Anticoagulants
Anticoagulants perform which of the following actions? Act directly
on platelet aggregation
Prevent thrombosis
Breakdown fibrin
Lyse pre-formed clots
Anticoagulant Subclasses
Which of these anticoagulants belongs to the subclass heparins?
clopidogrel warfarin rivaroxaban enoxaparin
Coumarins
How do coumarins prevent thrombus formation?
Working with other drug classes to decrease the thickness of blood
Inhibiting vitamin K-dependent clotting factors
Directly impacting platelet aggregation
Breaking down the fibrin in clots
Self Check: Thromboembolic Event
Which of the following patients is least at risk of a thromboembolic event?
Someone on a direct flight from Detroit, Michigan to Sydney, Australia
Someone who has been in a coma for a week following a stroke
Someone who has a broken foot and is learning to walk with an orthopedic boot
Someone who has a mechanical heart valve
Someone recovering from a bilateral knee replacement
