Pharmacodynamics Study Terms

Pharmacodynamics Study Terms Pharmacokinetics vs Pharmacodynamics •Pharmacokinetics is the study of what the body does to a drug •Pharmacodynamics is the study of what a drug does to the body Pharmacodynamics •Drug concentration at site of action & resulting effect ▫ Mechanism of action: Biochemical effects Physiologic effects ▫ Dose-response relationship ▫ Adverse effects •Scientific basis for selection and use of drugs Previous Play Next Rewind 10 seconds Move forward 10 seconds Unmute 0:00 / 0:15 Full screen Brainpower Read More Receptors •Recognition molecule for chemical mediator (ligand) ▫ Physiological mediators Hormones, neurotransmitters, inflammatory mediators ▫ Drug molecule Acute regulation of physiological & biochemical functions Do not create effects but modulate ongoing function May activate or inactive receptor May ⇧ or ⇩ decrease cell functions 4 Receptor Types •G protein-coupled •Enzyme-linked transmembrane •Intracellular (nuclear) •Transmembrane ion channels Lock & Key Model pharmacologic effect results from an interaction between drug & its receptor Selectivity •Drug is usually described by its more prominent effects ▫ Target receptors ▫ Rarely sufficiently selective to be described as specific •Multiple subtypes of receptors exist within classes ▫ Goal: increased efficacy & minimization of adverse effects Affinity "STRENGTH" of interaction between a ligand & a receptor Efficacy Potential MAX THERAPEUTIC response that a drug can produce