Working with the IACUC Questions And Answers With Verified Study Solutions

What does the acronym IACUC stand for? - Answer-Institutional Animal Care and Use Committee Which task is NOT a function of the IACUC? - Answer-Assist with writing the basic science portions of a grant application. Which of the following institutions must follow PHS guidelines for animal research? - Answer-All institutions that accept PHS funding Which organization is responsible for monitoring institutional compliance with PHS Policy? - AnswerOffice of Laboratory Animal Welfare Which of the following is a role of AAALAC International? - Answer-To conduct voluntary evaluations of institutional animal care and use programs. Which of the following is helpful to the IACUC when reviewing an animal protocol? - Answer-The use of a flowchart to illustrate complex experimental designs Which of the following statements about using a statistical analysis to justify animal numbers is TRUE? - Answer-A statistical analysis should be used whenever possible. Which of the following statements concerning selection of species for research is FALSE? - AnswerVertebrate species should be used instead of invertebrates whenever possible. A protocol submitted to the IACUC should demonstrate a clear hypothesis driven thought process and a thorough understanding of the number, species, housing and transport requirements of animals proposed for use in research studies - Answer-True Which of the following is NOT an example of reduction per the three Rs of Russell and Burch? - AnswerThe use of a new anesthetic that provides better induction and a shorter recovery periodThe Animal Welfare Regulations require the IACUC to do what two things regarding alternatives? - Answer-Ensure that the principal investigator has considered alternatives to painful or distressing procedures, and review a written assurance that alternatives are not available. The Johns Hopkins Center for Alternatives to Animal Testing (CAAT), the Institute for In Vitro Sciences, and the European Center for Validation of Alternative Methods (ECVAM) are primarily interested in what area? - Answer-Performing or sponsoring research into alternatives to animal use for research and testing. Which of the following is an example of refinement per the three Rs of Russell and Burch? - Answer-The use of a new blood collection technique that causes less pain and distress What is a primary mission of the Animal Welfare Information Center (AWIC), a part of USDA? - Answer-To provide assistance with alternatives and database searches. The three Rs of Russell and Burch stand for what? - Answer-Replacement, reduction, and refinement Which activity would place a study in pain category B? - Answer-Use as a breeder Which of the following activities WOULD place an animal in category E? - Answer-Lethal dose experiments in which animals are allowed to die without intervention What is the basis for the pain/distress classification system used by most institutions? - Answer-USDA pain/distress categories Which of the following activities would EXCLUDE an animal from USDA category D? - Answer-Studies in which animals are allowed to die without pain relief Endpoint criteria describe when it is time to do what? - Answer-Intervene to remove an animal from a study, sometimes by euthanizing an animal Which of the following activities would EXCLUDE an animal from USDA category B? - Answer-Blood collectionWhich of the following is TRUE regarding the Animal Welfare Regulations and duplication of experiments? - Answer-Unnecessary duplication of animal experiments is not allowed. Non-USDA regulated species are never required to be placed in a pain/distress category. - Answer-False Which parameter would NOT likely be part of an endpoint policy? - Answer-Number of animals approved by the IACUC for a particular protocol Which of the following are NOT allowed by USDA? - Answer-Changes in animal ownership and movement of animals between facilities during the postoperative period Which of the following would NOT be accepted by an IACUC as the sole justification for performing multiple major survival surgeries? - Answer-Cost savings Which of the following statements about the postoperative period is FALSE? - Answer-Postoperative analgesia is generally unnecessary in rodents. Surgery that penetrates and exposes a body cavity or produces substantial physical impairment is described as what kind of surgery? - Answer-Major