Working with the IACUC Questions With 100% Correct Answers.

Which of the following is helpful to the IACUC when reviewing an animal protocol? - Answer-The use of a flowchart to illustrate complex experimental designs USDA requires institutions to provide training in all of the following areas EXCEPT which one? - AnswerLaboratory animal facility design The principal investigator is responsible for ensuring all staff are trained to: - Answer-all of the Above Which statement about database searches for animal alternatives is FALSE? - Answer-If an alternative is available, it may be disregarded if the lab has more experience with the current technique. Which parameter would NOT likely be part of an endpoint policy? - Answer-Number of animals approved by the IACUC for a particular protocol Which of the statements concerning blood collection in mice and rats is TRUE? - Answer-Less painful alternatives to retroorbital blood collection are lateral saphenous, facial, and jugular vein blood collection. Protection for those who report misuse of animals or noncompliance is mandated by the Animal Welfare Regulations - Answer-True Some types of changes to an animal protocol can be approved administratively by veterinary verification and consultation. - Answer-True Which statement concerning nonsurvival surgery is TRUE? - Answer-If an animal undergoes nonsurvival surgery, the surgical site should be clipped and clean instruments should be used. Adjunctive methods of euthanasia, such as pithing frogs, should only be performed on animals that are already unconscious. - Answer-TrueWhich of the following is best used as a source of guidelines for animals housed in farm settings? - Answer-Guide for the Care and Use of Agricultural Animals in Research and Teaching An investigator wishes to use animals in an experiment that involves USDA pain category B, C, and D activities performed on the same animal. How should the animal be categorized? - Answer-Category D Which of the following activities WOULD place an animal in category E? - Answer-Lethal dose experiments in which animals are allowed to die without intervention Which of the following is NOT a reason to provide environmental enrichment? - Answer-To supplement the nutritional deficiencies of standard animal chow An agent that has high individual risk but low community risk would be in which Risk Group per the NIH Guidelines for Research Involving Recombinant or Synthetic Nucleic Acid Molecules? - Answer-Risk Group 3 What does the acronym IACUC stand for? - Answer-Institutional Animal Care and Use Committee When does the postoperative period end? - Answer-10-14 days Which of the following statements regarding the use of restraint on animals in a research study is FALSE? - Answer-Restraint can be used as a normal component of animal housing The three Rs of Russell and Burch stand for what? - Answer-Replacement, reduction, and refinement Which of the following statements about postoperative care records is TRUE? - Answer-For rodents, postoperative records for the group may be kept on cage cards or in laboratory notebooks. Endpoint criteria describe when it is time to do what? - Answer-Intervene to remove an animal from a study, sometimes by euthanizing an animalPrior to IACUC review of the animal use protocol application that describes procedures that are expected to cause more than momentary pain or distress, which of the following is mandated by the Animal Welfare Regulations? - Answer-A laboratory animal veterinarian must be consulted. Which of the following is not a justification for single housing social animals? - Answer-Reducing housing costs Which of the following activities would EXCLUDE an animal from USDA category C? - Answer-Surgery under appropriate anesthesia Which of statement is true about the euthanasia of neonatal mice? - Answer-An anesthetic overdose is an acceptable method. Which of the following is an example of refinement per the three Rs of Russell and Burch? - Answer-The use of a new blood collection technique that causes less pain and distress Recombinant DNA inserted into the genome of transgenic mice may NOT be covered by the NIH Guidelines for Research Involving Recombinant or Synthetic Nucleic Acid Molecules - Answer-True