Advanced Pathophysiology Studyguide

ADVANCED PATHOPHYSIOLOGY STUDYGUIDE Endogenous antigens - ..., infected host cells display pathogen proteins externally and are recognized as foreign; infected cell with virus and the viral antigens surround it Herpes virus - ...,, 1) HSV-1 - oral herpes, STD and contact, no vaccine, lifetime infection, treat the symptoms, sore Maternal antibody - ..., Natural, passive immunity, IgG, maternal IgG crosses placent, Antibody in a newborn animal which the newborn acquired through the placenta or colostrum (the first milk). Hypersensitivity reactions - ..., Different types; unexpected outcome after the administration of a medication; usually immune (IgE) mediated if previously exposed (Type I Hypersensitivity reaction); ranges from rash/hives to anaphylaxis (life threatening)- Cell mediated Development of allergies Alloimmunity - ..., Mast cell degranulates releasing histamine into tissue - histamine binds to receptors on endothelial cells - results in allergic symptoms. Autoimmunity - ..., Antigens trigger the formation of abnormal IgG in tissue and plasma, activates complement, An immune response directed against one's own self antigens. Systemic Lupus Erythematosus - ..., An autoimmune disease where the body's immune system damages its own tissues and cells. Characteristics are a bad rash or skin lesions. 40-50% of lupus patients develop renal disease, others develop hemolysis and anemia. Cause unknown. Graves Disease - ..., Autoantibody (IgG) that stimulates TSH receptor (type II hypersensitivity), An autoimmune disease, in which antibodies against the TSH (thyroid-stimulating hormone) receptor in thyroid epithelial cell membranes bind to it permanently and mimic the effects of TSH binding. This results in continual release of thyroid hormones into the bloodstream, causing the symptoms of hyperthyroidism. B-lymphocytes - ..., Responsible for humoral immunity. B-Cells are exposed to an antigen. When they encounter an antigen they imprint the antigen. Every bacteria has an antigenic site or antigenic marker. Immune system will respond to marker. Types of immunity - ..., Natural active immunity,Natural passive immunity,Artificial active immunity,Artificial passive immunity Immunotope - ... Epitope - ..., An area of the antigen molecle that stimulates the production of, and combines with, specific antibodies; also know as the antigenic determinant site Paratope - ..., what is the name of the part of the antibody that interacts with the antigen?