Lippincott Practice Q's Antepartal Care Study Guide

Which of the following is a component of the extracellular matrix that is correctly matched with its function? A. Collagen forms tough protein fi bers that are resistant to shearing forces. B. Elastin is the principal adhesive glycoprotein in connective tissue. C. Fibronectin forms a hydrated gel to allow the ECM to resist compressive forces. D. Glycosaminoglycans allow skin and lungs to stretch without tearing. E. Laminin imparts resilience to tissues such as cartilage. - A A 32-year-old woman with systemic lupus erythematosus (SLE) experiences joint pain and swelling that is accompanied by impaired compression/deformation abilities of her cartilage. Which of the following best describes the impaired extracellular matrix component and the impact it has on cartilage in this patient with SLE? A. Collagen of SLE cartilage lacks hydroxylysine and is less stable. B. Elastin of SLE cartilage is unable to stretch so cartilage cannot expand. C. Excess collagen in SLE cartilage causes joint stiffening. D. Laminin-mediated adhesion is interrupted, making SLE cartilage more diffuse. E. Reduced proteoglycan leads to impaired resilience of SLE cartilage. - E Which of the following properties is unique to cell adhesion mediated by selectins? A. Selectins are transmembrane proteins; other adhesion molecules are intracellular. B. Selectins mediate cell-to-matrix adhesion, not cellto- cell adhesions. C. Selectins have homophilic binding, with other selectins serving as their ligands. D. Selectins mediate bidirectional signaling between the cytoskeleton and the ECM. E. Selectins on one cell bind to the glycosylated ligands on another cell. - E Fibronectin is the ligand of a particular adhesion molecule. Therefore, that adhesion molecule most likely belongs to which family? A. Cadherins B. Collagens C. Immunoglobulin superfamily D. Integrins E. Selectins - D Therapies that block binding to which of the following types of adhesion molecules may have potential benefi t in preventing rhinovirus infection? A. ICAM-1 B. ICAM-2 C. L-Selectin D. P-Cadherin E. VLA-4 - A Sphingomyelin is a molecule identifi ed in a plasma membrane. Which of the following describes its location in that membrane? A. The outer membrane leafl et B. In a transmembrane arrangement C. Intercalated between phospholipids D. Anchored to lipids facing the cytosol E. Extending into the environment - A