SBB Preparing for ASCP(SBB) BOC Questions with Answers

Chemicals that send signals between cells are - Cytokines Antibodies are made by what cells? - Plasma cells Where do B cells mature? - Bone Marrow Where do T cells mature? - Thymus Coating of a cell with antibodies or complement is called? - Opsonization CD4 + cells are? - T helper cells The specific chemical group that provokes an antibody response - Epitope Blood groups are made of two main kinds of chemicals - Proteins, carbohydrates What is the function of the FC piece of an immunoglobulin? - Monocyte binding What is the only Ig that crosses the placenta? - IgG What does 2-ME OR DTT do to IgM antibodies? - Destroys disulfide bonds Which is the secretory Ig? - IgA Which Ig is responsible for allergic reaction's? - IgE Which IgG subclass does not bind complement? - IgG4 Which IgG sub classes are most clinically significant? - IgG 1 & 3 What is isotype switching? - Example IgM switches to IgG What is the end point of complement activation? - Hole in cell At what stage of complement cascade is it amplified? - C3 activation What two ions are needed for complement activity? - Ca++ and Mg++ Name two complement components that are anaphylatoxins - C3a and C5a What is the minimum number of days a BBK specimen must be kept? - Seven days post transfusion Name two groups for which weak D testing is required - Donors, NB of D- Moms What is required for crossmatch specimen to be used longer than three days? - Known history, not pregnant or transfusion last three months