What is the mechanism behind the fact that certain MHC molecules are associated with slow progression to
AIDS? Try to answer this queston (the subquestons below will help you to do that) as much as possible using
your own analysis. If you are stuck, refer to the hints at the end of the page.
1. Study Figure 2 of Kiepiela et al again. What does this result tell you about the relatonship betteen
CD8 responses to diferent HIV-1 proteins and iiral loads?
This figure shows that the
number of CD8 responses
to Gag correlates with the
viral load and that the viral
load decreases with an
increasing number of Gag
responses. The opposite is
true for CD8 Env
responses, since an
increasing amount of Env
responses causes an
increasing viral load. The
amount of CD8 responses
to Pol and Acc/Reg does
not have a clear infuence
on the viral load.
AIDS? Try to answer this queston (the subquestons below will help you to do that) as much as possible using
your own analysis. If you are stuck, refer to the hints at the end of the page.
1. Study Figure 2 of Kiepiela et al again. What does this result tell you about the relatonship betteen
CD8 responses to diferent HIV-1 proteins and iiral loads?
This figure shows that the
number of CD8 responses
to Gag correlates with the
viral load and that the viral
load decreases with an
increasing number of Gag
responses. The opposite is
true for CD8 Env
responses, since an
increasing amount of Env
responses causes an
increasing viral load. The
amount of CD8 responses
to Pol and Acc/Reg does
not have a clear infuence
on the viral load.
