BMS 300 Exam 3 corrections (Verified)

Following the initial effects of Novichok, Yulia and Sergei fell into a coma. As they sat comatose on the park bench, you would expect cAMP levels in the Skripals' sinoatrial and atrioventricular cardiomyocytes to be _________ and levels of adenylyl cyclase activity to be __________ as compared to normal. a. low, low b. low, high c. high, low d. high, high correct answers a. low, low In organophosphate poisoning, atropine is commonly administered as an antidote because it competes with acetylcholine binding to muscarinic receptors. You would expect atropine to offset bradycardia by reducing the effects of teh high acetylcholine concentrations at which of teh following site? a. at postganglionic parasympathetic synapses onto target cells b. at preganglionic parasympathetic synapses onto postganglionic neurons c. at postganglionic sympathetic synapses onto target cells d. at preganglionic sympathetic synapses onto postganglionic neurons e. all of the above correct answers a. at postganglionic parasympathetic synapses onto target cells Which of the following provides the best explanation for the bradycardia caused by the Novichock? a. the nicotinic receptors in the ganglia, but not the muscarinic receptors at synapses between the postganglionic parasympathetic neuron and the pacemaker cardiomyocytes become desensitized b. the nicotinic receptors at the synapses between the postganglionic sympathetic neuron and the pacemaker cardiomyocytes become desensitized c. the increase in the acetylcholine concentrations at the synapses between the postganglionic sympathetic neurons and the cardiomyocytes inhibits pacemaker cardiomyocyte activity d. the increased acetylcholine concentrations at the synapses between the postganglionic parasympathetic neuron and the cardiomyocytes decrease pacemaker cardiomyocytes activity by decreasing adenylyl cyclase activity e. a and d are correct correct answers e. a and d are correct You would expect that the initially observed tachycardia results from the increased concentrations of: a. acetylcholine at synapses in sympathetic chain ganglia b. acetylcholine at synapses onto cardiomyocytes c. acetylcholine at synapses in the cardiac ganglia d. norepinephrine at synapses onto cardiomyocytes e. e and d are correct correct answers e. e and d are correct