CRNI - Chemo Drugs

Methotrexate CORRECT ANSWER Uses: Lymphocytic leukemia, lymphomas, sarcomas - Practice: High dose MTX (over 200 mg/m2) causes bone marrow toxicity, use leucovorin "rescue" 12-24 hours after MTX infusion; potential for renal toxicity, push fluids; may cause photosensitivity - Side Effects: Leukopenia or Thrombocytopenia, Stomatitis (with increase doses), nephrotoxicity Cytarabine (Cytosar-U) CORRECT ANSWER Uses: Hodgkin's and Non-Hodgkin's Lymphoma; leukemia (acute, non-lymphocytic/acute, lymphocytic/acute, myelogenous and chronic myelocytic) - Practice: May be given IV or intrathecal; if given in conjunction with radiation the skin may peel - Side Effects: Flu like symptoms, conjunctivitis, alopecia, high fever Fluorouracil (5 FU) CORRECT ANSWER - Uses: Breast, ovary, liver, pancreas and gastrointestinal tract - Practice: May causephotosensitivity - Side Effects: Hyperpigmentation of vei