Walden 6630 Psychopharmacology Midterm Study Guide Latest 2022 Rated A+

Serotonin regulates Mood, emotion, feeding, and reproductive behavior This class of antidepressants binds to presynaptic SERT and inhibits them from reuptake of serotonin to increase levels in the synaptic cleft to bind with postsysnaptic 5HT2 receptors SSRIs First line therapy for MDD due to milder side effect profiles SSRIs Six Common SSRIs citalopram, escitalopram, fluoxetine, fluvoxamine, sertraline, paroxetine Onset of therapeutic benefit from SSRIs 4-6 weeks In addition to MDD, SSRIs also treat Chronic Anxiety, PTSD, OCD, and eating disorders (bulimia) Five Common side effects of SSRIs include Anxiety, insomnia, GI distress, sexual dysfunction (ED), SIADH Severe side effect of SSRIs in children/adolescents under age 25 years old suicidal ideation Life threatening adverse effect of SSRIs, especially when used in combination with other serotonergic drugs (SNRIs, TCAs, MAOIs, etc.) Serotonin SyndromeExcess accumulation of serotonin resulting in overstimulation of the nervous system Serotonin Syndrome Seven symptoms of Serotonin Syndrome Flushing, hyperthermia, agitation, muscle rigidity, seizure, coma, HYPERreflexia The treatment for serotonin syndrome Cyproheptadine (5-HT2 receptor antagonist) Cyproheptadine treats serotonin syndrome by blocking 5-HT2 receptors (serotonin antagonist) When SSRIs or SNRIs are stopped abruptly, common symptoms of withdrawal include Irritability, headaches, and insomnia